Favorable response to nivolumab in sarcomatoid malignant pleural mesothelioma: A case report

Kunishige, Michihiro; Kondo, Yoshihiro; Kadota, Naoki; Okano, Yasuaki; Machida, Hisanori; Hatakeyama, Nobuo; Hino, Hitoshi; Naruse, Keishi; Shinohara, Tsutomu; Shoji, Shuichi; Takeuchi, Eiji

doi:10.1016/j.cpccr.2022.100138

Cited by 1 publication

(2 citation statements)

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“…Malignant mesothelioma is a rare malignancy with an estimated global incidence of 0.30 cases per 100,000 inhabitants in 2020 [ 6 ]. And among a variety of plausible causes, asbestos exposure is widely considered the main risk factor as it is reported that up to 90% of MPM in men in Europe and North America are attributable to asbestos exposure [ 1 - 6 ]. The latency interval from the initial causal exposure to the development of the disease varies from 20 to 40 years [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

“…Malignant mesothelioma is a rare, insidious, and aggressive tumor that has always been described as highly common among patients with a history of chronic asbestos exposure [ 1 , 2 ]. Although asbestos industries have been restricted in many countries, past exposure is responsible for most present cases of the disease as it can take 10-40 years from the initial exposure to develop malignancy [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

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Unexplained Pleural Effusion Leads to the Revelation of a Malignant Mesothelioma: A Case Report

Rhazari¹,

Moueqqit²,

Gartini³

et al. 2022

Cureus

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Malignant mesothelioma is a rare and aggressive cancer that usually affects subjects with prior asbestos exposure, a major risk factor that has been widely known as carcinogenic, and its use is now controlled if not banned in many areas of the world. Malignant mesothelioma originates from mesothelial surface cells covering the serous cavities, and the pleura is its most common site. Malignant pleural mesothelioma (MPM) typically presents with pleural effusion and chest wall pain with wide pleural thickening at radiological investigation. Although the histological examination along with immunohistochemistry helps yield the diagnosis, clinicians and experts face many challenges in diagnosing malignant mesothelioma not only due to the rarity of the disease but also due to the similarities that the disease share with other malignancies. Here, we report a case of a 55-year-old male patient with a history of chronic asbestos work exposure for 12 years who initially presented with unexplained pleural effusion and chest wall pain and was lost to follow-up but came back later with a worsening clinical state. This case is specially presented to raise awareness against cases of unexplained pleural effusion and chest pain.

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