Favorable Vessel Healing After Nobori Biolimus A9-Eluting Stent Implantation

Konishi, Akihide; Shinke, Toshiro; Otake, Hiromasa; Takaya, Tomofumi; Nakagawa, Masayuki; Inoue, Tatsuo; Hasegawa, Hirotoshi; Osue, Tsuyoshi; Taniguchi, Yu; Iwasaki, Masanori; Nishio, Ryo; Hiranuma, Noritoshi; Kinutani, Hiroto; Kuroda, Minpei; Takahashi, Hidetoshi; Terashita, Daisuke; Shite, Junya; Hirata, Ken‐ichi

doi:10.1253/circj.cj-13-1474

Cited by 17 publications

(15 citation statements)

References 37 publications

(25 reference statements)

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“…Nonetheless, the differences were small and did not affect the strut coverage. Our data are in line with other BP-DES and everolimus-eluting stent studies, which presented completed vessel healing in humans and in the animal model at 6 months post implantation [19][20][21].…”

Section: Discussionsupporting

confidence: 91%

An optical coherence tomography study of neointimal morphology and strut coverage at different time intervals from implantation of biodegradable polymer‐coated sirolimus‐eluting stents

Legutko

Gil²,

Kałuża

et al. 2017

Cathet Cardio Intervent

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Section: Discussionsupporting

confidence: 91%

An optical coherence tomography study of neointimal morphology and strut coverage at different time intervals from implantation of biodegradable polymer‐coated sirolimus‐eluting stents

Legutko

Gil²,

Kałuża

et al. 2017

Cathet Cardio Intervent

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“…The range of the frequency was 7–10% in those studies [19, 20]. In the current study, 11 lesions (9.8%) had IS-Th, and the rate corresponded to these previous studies.…”

Section: Discussionsupporting

confidence: 88%

Vascular response to biolimus A-9 eluting stent in patients with shorter and prolonged dual antiplatelet therapy: optical coherence tomography sub-study of the NIPPON trial

et al. 2018

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Dual antiplatelet therapy (DAPT) with thienopyridine and aspirin is the standard care for the prevention of stent thrombosis. However, the optimal duration and effect of the duration of DAPT on intra-stent thrombus (IS-Th) formation are unknown. The NIPPON study (Nobori Dual Antiplatelet Therapy as Appropriate Duration) was an open label, randomized multicenter, assessor-blinded, trial designed to demonstrate the non-inferiority of shorter (6-month) DAPT to prolonged (18-month) DAPT, after biolimus A9 eluting stent implantation in 3773 patients at 130 sites in Japan. Among them, 101 patients were randomly allocated for an optical coherence tomography (OCT) sub-study to assess the difference of local IS-Th formation between the two groups. In addition to standard OCT parameters, the number of IS-Th formed was counted in each target stent at 8 months. Baseline patient characteristics were not different between the 6- and 18-month groups. IS-Th was detected in 9.8% of the cases and the presence of IS-Th was not significantly different between the two groups (10.9% in 6-month vs. 9.1% in 12-month, P = 0.76). Furthermore, the number of IS-Th formed was not significantly different between the two groups. This OCT sub-study was in line with the main NIPPON study which demonstrated the non-inferiority of 6-month DAPT to 18-month DAPT. Shorter DAPT duration did not promote progressive IS-Th formation at the mid-term time point.Electronic supplementary materialThe online version of this article (10.1007/s00380-018-1131-7) contains supplementary material, which is available to authorized users.

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“…11,14 Apposition was assessed by measuring the distance between the center of the endoluminal surface of the strut and the intersection between the lumen contour and the line connecting the center of the endoluminal strut side and the gravitational center of the vessel. 14,15 A malapposed strut was defined as a strut that had detached >140 µm (thickness of strut, 120 µm; antiproliferative drug and polymer, 20 µm) 16 from the underlying vessel wall. The percentages of malapposed or uncovered struts were calculated as the number of malapposed or uncovered struts/total number of struts in all cross sections of the lesion×100, respectively.…”

Section: Oct Imaging and Analysismentioning

confidence: 99%

Optical Coherence Tomography Guided Percutaneous Coronary Intervention With Nobori Stent Implantation in Patients With Non–ST-Segment–Elevation Myocardial Infarction (OCTACS) Trial

Antonsen

Thayssen

Maehara

et al. 2015

Circ: Cardiovascular Interventions

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Favorable Vessel Healing After Nobori Biolimus A9-Eluting Stent Implantation

Cited by 17 publications

References 37 publications

An optical coherence tomography study of neointimal morphology and strut coverage at different time intervals from implantation of biodegradable polymer‐coated sirolimus‐eluting stents

An optical coherence tomography study of neointimal morphology and strut coverage at different time intervals from implantation of biodegradable polymer‐coated sirolimus‐eluting stents

Vascular response to biolimus A-9 eluting stent in patients with shorter and prolonged dual antiplatelet therapy: optical coherence tomography sub-study of the NIPPON trial

Optical Coherence Tomography Guided Percutaneous Coronary Intervention With Nobori Stent Implantation in Patients With Non–ST-Segment–Elevation Myocardial Infarction (OCTACS) Trial

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