Favourable outcomes in patients with early-stage non-small-cell lung cancer operated on by video-assisted thoracoscopic surgery: a propensity score-matched analysis†

Dziedzic, Robert; Marjański, Tomasz; Bińczyk, F.; Polańska, Joanna; Sawicka, Wioletta; Rzyman, Witold

doi:10.1093/ejcts/ezy101

Cited by 34 publications

(33 citation statements)

References 22 publications

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“…As shown in Figure E, the concentration of total protein from exosomes in patients with NSCLC was 0.324 mg/mL, which was significantly higher than that of healthy individuals ( P = .0035). However, no significant differences were observed between healthy donors and early stage (stage I‐IIA) NSCLC . The total protein concentration from exosomes in patients with metastatic NSCLC was significantly higher compared to those with nonmetastatic NSCLC ( P < .0001), as described previously.…”

Section: Resultssupporting

confidence: 80%

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Tumor‐derived exosomal proteins as diagnostic biomarkers in non‐small cell lung cancer

et al. 2018

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Accumulating evidence supports a role for exosomal protein in diagnosis. The purpose of this study was to identify the tumor‐derived exosomal biomarkers in the serum that improve the diagnostic value in Chinese non‐small cell lung cancer (NSCLC) patients. Serum exosomes were isolated from healthy donors (n = 46) and NSCLC patients (n = 125) by ultracentrifugation and were characterized using transmission electron microscopy, qNano, and immunoblotting. Proteomic profiles (by mass spectrometry) revealed multiple differentially expressed proteins in the healthy and NSCLC groups. The exosomal expression levels of alpha‐2‐HS‐glycoprotein (AHSG) and extracellular matrix protein 1 (ECM1) increased significantly in the NSCLC patients compared to the healthy group. Alpha‐2‐HS‐glycoprotein showed diagnostic values with a maximum area under the receiver operating characteristic curve (AUC) as 0.736 for NSCLC vs healthy individuals (P < .0001) and 0.682 for early stage NSCLC vs healthy individuals (P < .01). Extracellular matrix protein 1 showed the diagnostic capacity with AUC values of 0.683 (P < .001) and 0.656 (P < .05) in cancer and early stage NSCLC compared to healthy individuals. When AHSG was combined with ECM1, the AUCs were 0.795 and 0.739 in NSCLC and early stage patients, respectively. Taken together, the combination of AHSG, ECM1, and carcinoembryonic antigen improved the diagnostic potential of NSCLC. The diagnosis values were AUC of 0.938 for NSCLC and 0.911 for early stage NSCLC vs healthy individuals. Our results suggest that novel proteomic signatures found in serum exosomes of NSCLC patients show potential usefulness as diagnostic tools.

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Section: Resultssupporting

confidence: 80%

“…NSCLC. 20 The total protein concentration from exosomes in patients with metastatic NSCLC was significantly higher compared to those with nonmetastatic NSCLC (P < .0001), as described previously.…”

Section: Characterizationofserumexosomesfrom Nsclcandhealthyindividsupporting

confidence: 80%

Tumor‐derived exosomal proteins as diagnostic biomarkers in non‐small cell lung cancer

et al. 2018

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“…VATS lobectomy for early stage lung cancer has been associated with lower complication rates, reduced postoperative pain, improved recovery, quality of life and long-term survival, compared with traditional open surgery (thoracotomy lobectomy). [30][31][32] In accord with our findings, insurance status, income and educational level were all associated with the likelihood of receiving VATS in a study performed in the USA. 33 The value of multidisciplinary team assessments and decision-making is well established in various medical disciplines 34 35 and has a class I recommendation in guidelines for cardiac surgery.…”

Section: Lung Cancersupporting

confidence: 87%

Household disposable income and long-term survival after pulmonary resections for lung cancer

Sachs

Jackson

Sartipy

2020

Thorax

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IntroductionSocioeconomic disparities have been linked to survival differences in patients with lung cancer. Swedish healthcare is tax-funded and provides equal access to care, therefore, survival following lung cancer surgery should be unrelated to household income. The aim of this study was to investigate the association between household disposable income and survival following surgery for lung cancer in Sweden.MethodsWe conducted a nationwide population-based cohort study including all patients who underwent pulmonary resections for lung cancer in Sweden 2008–2017. Individual-level record linkages between national quality and health-data registers were performed to acquire information regarding socioeconomic status and medical history. Cox regression by quintiles of household disposable income was used to estimate the adjusted risk for all-cause mortality.ResultsWe included 5500 patients and the age-adjusted and sex-adjusted incidence rate of death per 100 person-years was 15 and 9.4 in the lowest and highest income quintile, respectively (mean follow-up time 3.2 years). Deprived patients were older, had more comorbidities and were less likely to have preoperative positron emission tomography or minimally invasive surgery, compared with patients with higher income. The adjusted HR for death was 0.77 (95% CI: 0.62 to 0.96) for the highest income quintile compared with the lowest.ConclusionsWe found an association between household disposable income and survival in patients who underwent surgery for lung cancer in Sweden, despite tax-funded universal health coverage. The association remained after adjustment for differences in baseline characteristics.

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“…Liu Baolin [9] applied pulmonary segmentectomy under total thoracoscope in clinical treatment of peripheral early lung cancer and pulmonary metastasis tumor and drew the conclusion that pulmonary segmentectomy under total thoracoscope has high safety and feasibility in treatment of peripheral early lung cancer and pulmonary metastasis tumor. Sun Guogen [10] considered that, thoracoscopic surgery has better curative effect than minimally invasive thoracotomy.…”

Section: Discussionmentioning

confidence: 99%

Discussion on Feasibility and Safety of Pulmonary Segmentectomy under Total Thoracoscope in Treatment of Peripheral Early Lung Cancer and Pulmonary Metastasis Tumor

Zhang¹,

Wei²

2018

2018 7th International Conference on Medical Engineering and Biotechnology (MEDEB 2018)

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Objective: to discuss feasibility and safety of pulmonary segmentectomy under total thoracoscope in treatment of peripheral early lung cancer and pulmonary metastasis tumor. Method: the clinical data of 25 patients with peripheral early lung cancer and pulmonary metastasis tumor who received pulmonary segmentectomy under total thoracoscope in our hospital from February 2016 to February 2018 were retrospectively analyzed. Results: the operation was completed successfully for all 25 patients. Intraoperative bleeding volume (105.6±6.2)ml, duration of operation (137.6±8.0)min, duration of postoperative drainage (2.6±0.7)d, duration of hospitalization (7.1±1.3)d. Pulmonary atelectasis happened to 3 patients after the operation. After the corresponding treatment was given, the symptom disappeared. Bronchopleural fistula, respiratory failure, infection of incisional wound and other severe complications were not found. The wound healing was good, and scar tissue was not found. During 2-year postoperative follow-up visit, tumor metastasis or relapse was not seen. Conclusion: pulmonary segmentectomy under total thoracoscope has high safety in treatment of peripheral early lung cancer and pulmonary metastasis tumor. Besides, it has good feasibility. Therefore, it deserves to be promoted.

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Favourable outcomes in patients with early-stage non-small-cell lung cancer operated on by video-assisted thoracoscopic surgery: a propensity score-matched analysis†

Abstract: Patients with early-stage NSCLC operated on with VATS had fewer complications, shorter postoperative length of stay and better OS compared to those who were operated on by thoracotomy.

Cited by 34 publications

References 22 publications

Tumor‐derived exosomal proteins as diagnostic biomarkers in non‐small cell lung cancer

Tumor‐derived exosomal proteins as diagnostic biomarkers in non‐small cell lung cancer

Household disposable income and long-term survival after pulmonary resections for lung cancer

Discussion on Feasibility and Safety of Pulmonary Segmentectomy under Total Thoracoscope in Treatment of Peripheral Early Lung Cancer and Pulmonary Metastasis Tumor

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