Fbxo25 controls Tbx5 and Nkx2–5 transcriptional activity to regulate cardiomyocyte development

Jeong, Hoe-Su; Jung, Eun-Shil; Sim, Ye-Ji; Kim, Sujin; Jang, Jae-Woo; Hong, Ki-Sung; Lee, Won Young; Chung, Hyung-Min; Park, Kyung‐Tae; Kim, Chang Hoon; Kim, Kye-Seong

doi:10.1016/j.bbagrm.2015.02.002

Cited by 12 publications

(10 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…FBXO_25 (F_box protein 25) also showed increased expression between the C. butyricum -treated and control group. This is a member of the MAPK pathway that regulates numerous biological processes including cell growth, differentiation and apoptosis in skeletal muscle development [ 36 ]. FBXO_25 may facilitate muscle development in the C. butyricum -treated group by specifically activating the MAPK signaling pathway.…”

Section: Discussionmentioning

confidence: 99%

RNA-Seq transcriptome analysis of breast muscle in Pekin ducks supplemented with the dietary probiotic Clostridium butyricum

et al. 2018

View full text Add to dashboard Cite

BackgroundIncreased attention is being paid to breast muscle yield and meat quality in the duck breeding industry. Our previous report has demonstrated that dietary Clostridium butyricum (C. butyricum) can improve meat quality of Pekin ducks. However, the potential biological processes and molecular mechanisms that are modulated by dietary C. butyricum in the breast muscle of Pekin ducks remain unknown.ResultsSupplementation with C. butyricum increased growth performance and meat yield. Therefore, we utilized de novo assembly methods to analyze the RNA-Seq transcriptome profiles in breast muscle to explore the differentially expressed genes between C. butyricum-treated and control Pekin ducks. A total of 1119 differentially expressed candidate genes were found of which 403 genes were significantly up-regulated and 716 genes were significantly down-regulated significantly. qRT-PCR analysis was used to confirm the accuracy of the of RNA-Seq results. GO annotations revealed potential genes, processes and pathways that may participate in meat quality and muscle development. KEGG pathway analysis showed that the differentially expressed genes participated in numerous pathways related to muscle development, including ECM-receptor interaction, the MAPK signaling pathway and the TNF signaling pathway.ConclusionsThis study suggests that long-time dietary supplementation with C. butyricum can modulate muscle development and meat quality via altering the expression patterns of genes involved in crucial metabolic pathways. The findings presented here provide unique insights into the molecular mechanisms of muscle development in Pekin ducks in response to dietary C. butyricum.Electronic supplementary materialThe online version of this article (10.1186/s12864-018-5261-1) contains supplementary material, which is available to authorized users.

show abstract

Section: Discussionmentioning

confidence: 99%

RNA-Seq transcriptome analysis of breast muscle in Pekin ducks supplemented with the dietary probiotic Clostridium butyricum

et al. 2018

View full text Add to dashboard Cite

show abstract

“…The product encoded by FBXO25 is a member of the F-box protein family and is involved in phosphorylation-dependent ubiquitination. Fbxo25 may act as a ubiquitin E3 ligase to degrade cardiac transcription factors and control the transcriptional activity of the cardiac transcription factors Tbx5 and Nkx2-5, which play key roles in human cardiac development ( 24 ). The protein encoded by DLGAP2 is a membrane-associated protein that is biallelically expressed in the brain and plays roles in synapse organization and signalling in neuronal cells.…”

Section: Discussionmentioning

confidence: 99%

Isolated chromosome 8p23.2-pter deletion: Novel evidence for developmental delay, intellectual disability, microcephaly and neurobehavioral disorders

Shi¹,

Lin²,

Chen³

et al. 2017

Molecular Medicine Reports

View full text Add to dashboard Cite

The current study presents a patient carrying a de novo ~6 Mb deletion of the isolated chromosome 8p23.2-pter that was identified with a single-nucleotide polymorphism array. The patient was characterized by developmental delay (DD)/intellectual disability (ID), microcephaly, autism spectrum disorder, attention-deficit/hyperactivity disorders and mildly dysmorphic features. The location, size and gene content of the deletion observed in this patient were compared with those in 7 patients with isolated 8p23.2 to 8pter deletions reported in previous studies (4 patients) or recorded in the Database of Chromosomal Imbalance and Phenotype in Humans Using Ensembl Resources (DECIPHER) database (3 patients). The deletions reported in previous studies were assessed using a chromosomal microarray analysis. The 8p23.2-pter deletion was a distinct microdeletion syndrome, as similar phenotypes were observed in patients with this deletion. Furthermore, following a detailed review of the potential associations between the genes located from 8p23.2 to 8pter and their clinical significance, it was hypothesized that DLG associated protein 2, ceroid-lipofuscinosis neuronal 8, Rho guanine nucleotide exchange factor 10 and CUB and sushi multiple domains 1 may be candidate genes for DD/ID, microcephaly and neurobehavioral disorders. However, firm evidence should be accumulated from high-resolution studies of patients with small, isolated, overlapping and interstitial deletions involving the region from 8p23.2 to 8pter. These studies will allow determination of genotype-phenotype associations for the specific genes crucial to 8p23.2-pter.

show abstract

“…This adapter protein is known to interact with the Skp1-cullin-1 complex to degrade cardiac transcription factors [ 130 ]. Indeed, Fbxo25 facilitates the degradation of Nkx2.5 (Nk2 homeobox 5), Isl1 (insulin gene enhancer protein Isl-1, also known as islet-1), Hand1 (heart and neural crest derivatives expressed 1), Tbx5 (T-box transcription factor 5), and Mef2C (myocyte enhancer factor 2C), suggesting a pivotal function for muscle protein homeostasis and cardiac development [ 130 , 131 ].…”

Section: The Role Of Cullin-1 Based Crls In Cross-striated Musclesmentioning

confidence: 99%

The Role of Cullin-RING Ligases in Striated Muscle Development, Function, and Disease

Blondelle

Biju

Lange

2020

IJMS

View full text Add to dashboard Cite

The well-orchestrated turnover of proteins in cross-striated muscles is one of the fundamental processes required for muscle cell function and survival. Dysfunction of the intricate protein degradation machinery is often associated with development of cardiac and skeletal muscle myopathies. Most muscle proteins are degraded by the ubiquitin–proteasome system (UPS). The UPS involves a number of enzymes, including E3-ligases, which tightly control which protein substrates are marked for degradation by the proteasome. Recent data reveal that E3-ligases of the cullin family play more diverse and crucial roles in cross striated muscles than previously anticipated. This review highlights some of the findings on the multifaceted functions of cullin-RING E3-ligases, their substrate adapters, muscle protein substrates, and regulatory proteins, such as the Cop9 signalosome, for the development of cross striated muscles, and their roles in the etiology of myopathies.

show abstract

Fbxo25 controls Tbx5 and Nkx2–5 transcriptional activity to regulate cardiomyocyte development

Cited by 12 publications

References 37 publications

RNA-Seq transcriptome analysis of breast muscle in Pekin ducks supplemented with the dietary probiotic Clostridium butyricum

RNA-Seq transcriptome analysis of breast muscle in Pekin ducks supplemented with the dietary probiotic Clostridium butyricum

Isolated chromosome 8p23.2-pter deletion: Novel evidence for developmental delay, intellectual disability, microcephaly and neurobehavioral disorders

The Role of Cullin-RING Ligases in Striated Muscle Development, Function, and Disease

Contact Info

Product

Resources

About