FC‐23 
Feline plasma cell pododermatitis: a retrospective study of 26 cases

Abstract

During the last few years, reports have appeared claiming that lufenuron diminished or even cured dermatophyte infections in cats and dogs. As these observations have a rather anecdotal character leading to some ambiguity in the literature, it was decided to test lufenuron in a generally accepted animal model for dermatomycotic infection. The test was carried out in guinea pigs artificially infected with Microsporum canis on scarified dorsal skin and orally treated with lufenuron (Programä). The efficacy of up to five doses of 80 mg/kg was assessed 7 and 14 days after the start of treatment. All animals failed to show any improvement in skin lesions as compared to the vehicle-only treated animals. Clinical symptoms taken into account were scaling, crust formation, erythema, and exudation. Neither the number of treatments (one or five) nor the dose range (40 or 80 mg/ kg) made any difference. Itraconazole, tested earlier under identical circumstances, resulted in a clear and consistent improvement at day 7 of the infection at a dose of 15 mg/kg, given either in one dose or spread over several days. The absence of antimycotic activity of lufenuron in this established animal model constitutes a significant element in the discussion on the antifungal potency of lufenuron and supports the fact that there is, as yet, no evidence that benzoylphenyl urea derivative compounds have an effect on chitin synthesis in fungi.

Virale Dermatosen bei Hund und Katze

“…Die Ursachei st bis heute unbekannt. Glukokortikoide,D oxycyclin( 10 mg/kg KM/Tag)u nd auch chirurgischeE ingriffe werdena ls Therapiemöglichkeiten vorgeschlagen (19,39,40,84).…”

A synthetic review of notoedres species mites and mange

“…Notoedric mange is a potentially fatal syndrome of contagious dermatitis with systemic complications caused by obligately parasitic, burrowing mites of the genus Notoedres , family Sarcoptidae (Guaguere et al 1999; Scott et al 2001; Gross, 2005). These mites are closely related to mites in the genera Sarcoptes, Psoroptes, Chorioptes and Otodectes and include at least 41 named species in the genus (Klompen, 1992).…”

Nasal swelling due to plasma cell infiltrate in a cat without plasma cell pododermatitis

“…Plasma cell pododermatitis is an uncommon disease in cats and has been described as exclusively affecting the footpads 1–7 . The aetiology is unknown, but the marked plasma cell infiltrate, consistent hypergammaglobulinaemia, and response to immuno‐modulating therapy suggest an immune‐mediated basis.…”

“…An infectious aetiology has also been suggested but has not been definitively established. There are conflicting reports regarding the involvement of feline immunodeficiency virus (FIV) 6–8 . Guaguere and Prelaud suggested that plasma cell pododermatitis is a cutaneous reaction pattern with multiple causes, including infections 6 .…”

“…There are conflicting reports regarding the involvement of feline immunodeficiency virus (FIV) 6–8 . Guaguere and Prelaud suggested that plasma cell pododermatitis is a cutaneous reaction pattern with multiple causes, including infections 6 . A recent study failed to identify doxycycline‐sensitive infectious organisms with immunohistochemistry and polymerase chain reaction assays 9 …”