Fc Epitopes for Human Rheumatoid Factors and the Relationships of Rheumatoid Factors to the Fc Binding Proteins of Microorganisms

Nardella, Francis A.; Oppliger, Ina R.; Stone, G C; Sasso, Eric H.; Mannik, Mart; Sjöquist, John; Schröder, A. K.; Christensen, Poul; Johansson, Peter; Björck, Lars

doi:10.3109/03009748809096761

Cited by 21 publications

(10 citation statements)

References 35 publications

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“…Furthermore, the Fc-binding proteins of groups A, C and G streptococci, as well as the Fc-binding proteins induced on cell surfaces by herpes simplex virus type I, also bind to the same area of IgG. These findings indicate that RFs bear the conformational internal image of these microbial proteins and suggest that RFs could appear as antibodies to the idiotypic determinants on antibodies to microbial Fc-binding proteins (Nardella et al, 1988). Moreover, C. Nordling et al has shown that monoclonal antiidiotype antibodies C1C3 to monoclonal antibodies, recognizing epitopes of native mouse type II collagen molecule, are rheumatoid factor (Nordling et al, 1991;Holmdahl et al, 1986).…”

Section: Introductionmentioning

confidence: 84%

Role of idiotype–anti-idiotype interactions in the induction of collagen-induced arthritis in rats

Beduleva

Menshikov

2010

Immunobiology

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Section: Introductionmentioning

confidence: 84%

Role of idiotype–anti-idiotype interactions in the induction of collagen-induced arthritis in rats

Beduleva

Menshikov

2010

Immunobiology

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“…A number of studies have reported generation of RF-like antibodies in animals immunized with bacterial and viral Ig-binding proteins [1][2][3][4][5][6][7][8][9][10][11]. Three possible explanations have been proposed to account for generation of these antibodies and for the finding that the resulting species reactivity profile of the anti-IgGbinding antibody mimics the reactivity profile of the bacterial or viral Fc-binding protein immunogen.…”

Section: Discussionmentioning

confidence: 99%

“…Bacterial immunoglobulin (Ig)G-binding proteins, such as staphylococcal protein A and streptococcal protein G, have many similarities in their reactivity to a family of autoantibodies against IgG, designated rheumatoid factors (RF), and present in the serum of certain patients with rheumatoid arthritis [1][2][3][4][5][6][7][8][9]. Rheumatoid factors and bacterial IgG-binding proteins bind to a similar site on the Fc region of IgG and also demonstrate similar patterns of species-specific reactivities [1][2][3][4][5][6][7][8][9]. These observations led to the hypothesis that RF antibodies might arise as part of an idiotype network in which the anti-idiotype to an antibody which specifically recognized a bacterial IgG-Fc-binding protein would result in an internal image of the antigen with similar Fc-binding characteristics [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Do Chickens Immunized with Bacterial Immunoglobulin G‐Binding Proteins Produce Rheumatoid Factor‐Like Antibodies?

et al. 1998

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An association between the production of rheumatoid factor (RF)-like antibodies in animals immunized with bacterial immunoglobulin (Ig)G-binding proteins has been noted. Three potential explanations have been proposed: (1) altered host IgG due to binding of the immunogen; (2) B-cell superantigenic properties of the binding proteins; and (3) idiotype-anti-idiotype response leading to an antibody which acts as an antigen mimic. In order to distinguish among these possibilities, it is necessary to carry out studies in animals whose IgG does not react with the IgG-binding protein immunogen. Consequently, we have determined the effects of immunizing chickens with a purified group C streptococcal IgG-binding protein, FcRc, a bacterium expressing this protein, and appropriate control immunogens. The results of these studies provided evidence for production of specific antibodies to FcRc in groups of chickens immunized with either the pure protein or bacteria expressing the protein. No significant association with production of RF-like antibodies was noted, favouring the altered IgG-binding explanation for the association between RF-like antibodies and immunization with the bacterial IgG-binding proteins.

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“…The hypothesis that rheumatoid factors are anti-idiotype antibodies bearing an internal image of microbial Fc receptors is an attractive one, and has been proposed by several workers [21,27]. However, little experimental evidence is available to support this.…”

Section: Discussionmentioning

confidence: 99%

Spontaneous in vitro production of rheumatoid factor during infectious exacerbations of cystic fibrosis: correlation with circulating immune complex levels

Keogan¹,

Callaghan²,

Yanni³

et al. 1993

Clinical and Experimental Immunology

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SUMMARYRheumatoid factor (RF) production has been demonstrated during infections, mcluding itifectious exacerbations of cystic fibrosis (CT). The aim of this study was to evaluate the relationship of RF production to infection, and examine the mechanisms involved. Serial peripheral blood mononuclear ccll(PBMC) cultures with nieasuremenl of spontaneous production of IgM RF, IgA RF, total IgM and IgA, and measurement of serum levels of immune complexes were earned out during exacerbations of CF. The percentage of B cells expressing CDS was examined in a second cohort of acutely infected CF patients, and related to IgM RF production. IgM RF productioti was significantly elevated duritig acute itifeclion compared with convalescence (/'<005). stable CF subjects (P<0005) and normal controls (P<00.^). IgM RF production did not correlate with total IgM production in the majority of patients, but was closely related to circulating immune complex levels in 8/10 subjects. IgA RF production did not increase significantly during infection, and did not correlate with total IgA or IgM RFproduction.or with circulating immune complex levels. CD5' B cells were not increased in the CF group, and the percentage of CD5 ' B cells did not correlate with IgM RF synthesis. These observations suggest that RF production during infection is specifically induced, possibly by immune complex autoimmunization. and is not simply the result of polyelonal B cell activation. Different patterns of IgM RF and IgA RF synthesis suggest different mechanisms of induction.

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Fc Epitopes for Human Rheumatoid Factors and the Relationships of Rheumatoid Factors to the Fc Binding Proteins of Microorganisms

Cited by 21 publications

References 35 publications

Role of idiotype–anti-idiotype interactions in the induction of collagen-induced arthritis in rats

Role of idiotype–anti-idiotype interactions in the induction of collagen-induced arthritis in rats

Do Chickens Immunized with Bacterial Immunoglobulin G‐Binding Proteins Produce Rheumatoid Factor‐Like Antibodies?

Spontaneous in vitro production of rheumatoid factor during infectious exacerbations of cystic fibrosis: correlation with circulating immune complex levels

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