Fc Gamma Receptor Signaling in Mast Cells Links Microbial Stimulation to Mucosal Immune Inflammation in the Intestine

Chen, Xiao; Feng, Bai–Sui; Zheng, Peng‐Yuan; Liao, Xue-Qing; Chong, Jasmine; Tang, Shangguo; Yang, Ping‐Chang

doi:10.2353/ajpath.2008.080487

Cited by 21 publications

(24 citation statements)

References 37 publications

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“…FcεRI has been extensively studied in cases of allergy, asthma and certain parasitic infections, but its role in bacterial infections has not been well defined [4,36]. The MC FcγRI has been identified to play a role in flagellin-induced inflammatory bowel disease [37]. Upon encounter with flagellated bacteria, the host can react by binding flagellin to cell surface TLR-5 for immune signaling activation and/or to generate flagellin-specific antibody.…”

Section: Pathogen Recognition By Mcsmentioning

confidence: 99%

Mast cells: multitalented facilitators of protection against bacterial pathogens

Trivedi

Guentzel

Rodriguez

et al. 2013

Expert Review of Clinical Immunology

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Mast cells are crucial effector cells evoking immune responses against bacterial pathogens. The positioning of mast cells at the host–environment interface, and the multitude of pathogen-recognition receptors and preformed mediator granules make these cells potentially the earliest to respond to an invading pathogen. In this review, the authors summarize the receptors used by mast cells to recognize invading bacteria and discuss the function of immune mediators released by mast cells in control of bacterial infection. The interaction of mast cells with other immune cells, including macrophages, dendritic cells and T cells, to induce protective immunity is highlighted. The authors also discuss mast cell-based vaccine strategies and the potential application in control of bacterial disease.

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Section: Pathogen Recognition By Mcsmentioning

confidence: 99%

Mast cells: multitalented facilitators of protection against bacterial pathogens

Trivedi

Guentzel

Rodriguez

et al. 2013

Expert Review of Clinical Immunology

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“…41 However, their role in the pathogenesis of these disorders, as well as their exact contribution to the composition of the inflammatory infiltrate, is largely obscure.…”

Section: In Vivo Evidence Of Concomitant Accumulation Of Mcs and Iga-mentioning

confidence: 99%

Mast cells enhance proliferation of B lymphocytes and drive their differentiation toward IgA-secreting plasma cells

Merluzzi

Frossi

Gri

et al. 2010

Blood

117

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“…Its receptor ST2 (also called IL-1 receptor-related protein 1) is highly expressed by MC. Acting via ST2, IL-33 participates in MC activation in murine models of anaphylaxis and arthritis, serving both as a direct MC activator and as a factor that primes MC for enhanced cytokine release upon subsequent stimulation by IgE and IgG (29)(30)(31)(32). IL-33 also prominently modulates the MC phenotype, promoting accumulation of MC protease 6 (the murine ortholog of human tryptase β) in vitro and in vivo (33).…”

mentioning

confidence: 99%

IL-33/ST2 axis promotes mast cell survival via BCLXL

Wang

Kaieda

Ameri

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

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Mast cells (MC) are potent innate immune cells that accumulate in chronically inflamed tissues. MC express the IL-33 receptor IL-1 receptor-related protein ST2 at high level, and this IL-1 family cytokine both activates MC directly and primes them to respond to other proinflammatory signals. Whether IL-33 and ST2 play a role in MC survival remains to be defined. In skin-derived human MC, we found that IL-33 attenuated MC apoptosis without altering proliferation, an effect mediated principally through the antiapoptotic molecule B-cell lymphoma-X large (BCLXL). Murine MC demonstrated a similar mechanism, dependent entirely on ST2. In line with these observations, St2−/− mice exhibited reduced numbers of tissue MC in inflamed arthritic joints, in helminthinfected intestine, and in normal peritoneum. Together, these data reveal a cell-intrinsic role for the IL-33/ST2 axis in the regulation of apoptosis in MC, identifying thereby a previously unappreciated pathway supporting expansion of the MC population with inflammation.arthritis | helminth infection M ast cells (MC) are tissue-resident effector cells that contribute both to innate and adaptive immunity (1). MC help defend against bacterial and helminthic infection (2, 3) and play a role in tissue remodeling (4, 5). MC can also contribute to a variety of allergic and nonallergic inflammatory diseases, such as anaphylaxis, atopic dermatitis, asthma, inflammatory arthritis, psoriasis, and multiple sclerosis (6, 7). Under many of these conditions, the number of MC in affected tissues increases by tenfold or more, amplifying the contribution of MC-derived mediators to ongoing inflammation (6-8). Regulation of the MC population is poorly understood, and therapeutic intervention to limit MC accumulation potentially could attenuate injury associated with inflammatory diseases (9, 10).The survival of mature MC in tissues depends on signals from neighboring cells (11,12). The single most important mediator in this process is stem cell factor (SCF), a master regulator of MC proliferation, differentiation, survival, and activation. Mice with genetic mutations affecting SCF or its receptor Kit have few or no MC in healthy or inflamed tissues, whereas activating mutations of Kit give rise to pathologic mastocytosis (13-15). IL-3 is another well-recognized MC growth factor (16). SCF/Kit and IL-3 interface with several antiapoptotic pathways, up-regulating the antiapoptotic protein B-cell lymphoma-2 (BCL-2) and downregulating the proapoptotic protein Bim (14,(17)(18)(19). Aside from SCF/Kit and IL-3, other cytokines have been reported to support MC survival, but their effects appear to be restricted to specific MC subtypes. IL-4 promotes survival of intestinal MC via both BCL-2 and B-cell lymphoma-X large (BCLXL) but may suppress survival in human cord blood MC as well as murine bone marrowderived MC (BMMC) (20-23). IL-10 can either promote or impair survival depending on the type of MC studied (21,22).Recently, substantial attention has focused on the role of IL-33 in MC biolog...

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Fc Gamma Receptor Signaling in Mast Cells Links Microbial Stimulation to Mucosal Immune Inflammation in the Intestine

Cited by 21 publications

References 37 publications

Mast cells: multitalented facilitators of protection against bacterial pathogens

Mast cells: multitalented facilitators of protection against bacterial pathogens

Mast cells enhance proliferation of B lymphocytes and drive their differentiation toward IgA-secreting plasma cells

IL-33/ST2 axis promotes mast cell survival via BCLXL

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