Abstract:The use of passively-administered neutralizing antibodies is a promising approach for the prevention and treatment of SARS-CoV-2 infection. Antibody-mediated protection may involve immune system recruitment through Fc-dependent activation of effector cells and the complement system. However, the role of Fc-mediated functions in the efficacious in vivo neutralization of SARS-CoV-2 is not yet clear. Delineating the role this process plays in antibody-mediated protection will have a great impact on the design of … Show more
“…Moreover, Fcmediated complement activation can exert a broad range of immunomodulatory functions, with activation of C1q resulting in antibody-mediated complement activation, and complement-dependent cytotoxicity. However, a recent study showed the diminished role of the Fc region in protecting against lethal SARS-CoV-2 infections in K18-hACE2 transgenic mice [42]. This study showed that potent NAbs do not rely on Fc effector functions to provide optimal protection when administered as therapy.…”
Section: What Is the Role Of Antibody Fc Portion In Therapeutic Antibodies Against Sars-cov-2?mentioning
“…Moreover, Fcmediated complement activation can exert a broad range of immunomodulatory functions, with activation of C1q resulting in antibody-mediated complement activation, and complement-dependent cytotoxicity. However, a recent study showed the diminished role of the Fc region in protecting against lethal SARS-CoV-2 infections in K18-hACE2 transgenic mice [42]. This study showed that potent NAbs do not rely on Fc effector functions to provide optimal protection when administered as therapy.…”
Section: What Is the Role Of Antibody Fc Portion In Therapeutic Antibodies Against Sars-cov-2?mentioning
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