Fc receptor-like 3 (−169T&gt;C) polymorphism increases the risk of tendinopathy in volleyball athletes: a case control study

Salles, José Inácio; Lopes, Lucas Rafael; Duarte, Maria Eugênia Leite; Morrissey, Dylan; Martins, Marilena Bezerra; Machado, Daniel Escorsim; Guimarães, João Antônio Matheus; Perini, Jamila Alessandra

doi:10.1186/s12881-018-0633-6

Cited by 23 publications

(46 citation statements)

References 53 publications

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“…84 Furthermore, Treg are also involved in the inflammatory status in both OA and tendinopathy. 85,86 Herein, six of the identified miRNAs were found to be able to modulate Treg polarization and stabilization. miR-146a-5p contrasts the polarization toward inflammatory Th1, 87 miR-99a-5p affects inducible Treg polarization by targeting mammalian target of rapamycin (mTOR), 88 and miR-10a-5p also targets Treg by stabilizing the expression of FoxP3.…”

Section: Target and Effect Prediction Of Hamsc-ev Mirnas In The Setmentioning

confidence: 99%

Amniotic membrane-mesenchymal stromal cells secreted factors and extracellular vesicle-miRNAs: Anti-inflammatory and regenerative features for musculoskeletal tissues

Ragni

Papait

Orfei

et al. 2021

Stem Cells Translational Medicine

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Human amniotic membrane-derived mesenchymal stromal cells (hAMSCs) are easily obtained in large quantities and free from ethical concerns. Promising therapeutic results for both hAMSCs and their secreted factors (secretome) were described by several in vitro and preclinical studies, often for treatment of orthopedic disorders such as osteoarthritis (OA) and tendinopathy. For clinical translation of the hAMSC secretome as cell-free therapy, a detailed characterization of hAMSC-secreted factors is mandatory. Herein, we tested the presence of 200 secreted factors and 754 miRNAs in extracellular vesicles (EVs). Thirty-seven cytokines/chemokines were identified at varying abundance, some of which involved in both chemotaxis and homeostasis of inflammatory cells and in positive remodeling of extracellular matrix, often damaged in tendinopathy and OA. We also found 336 EV-miRNAs, 51 of which accounted for more than 95% of the genetic message. A focused analysis based on miRNAs related to OA and tendinopathy showed that most abundant EV-miRNAs are teno-and chondro-protective, able to induce M2 macrophage polarization, inhibit inflammatory T cells, and promote Treg. Functional analysis on IL-1β treated tenocytes and chondrocytes resulted in downregulation of inflammation-associated genes. Overall, presence of key regulatory molecules and miRNAs explain the promising therapeutic results of hAMSCs and their secretome for treatment of musculoskeletal conditions and are a groundwork for similar studies in other pathologies. Furthermore, identified molecules will pave the way for future studies aimed at more Enrico Ragni and Andrea Papait contributed equally to the work.

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Section: Target and Effect Prediction Of Hamsc-ev Mirnas In The Setmentioning

confidence: 99%

Amniotic membrane-mesenchymal stromal cells secreted factors and extracellular vesicle-miRNAs: Anti-inflammatory and regenerative features for musculoskeletal tissues

Ragni

Papait

Orfei

et al. 2021

Stem Cells Translational Medicine

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“…8 studies investigating genes variations associated with rotator cuff tears were included in this review. 6 studies were focused on candidate genes [19–24] and 2 studies were GWASs [25, 26].…”

Section: Resultsmentioning

confidence: 99%

“…As demonstrated in in-vivo studies, the immune cells play a key role in the pathophysiology of rotator cuff tears. Salles et al found an increased risk of tendinopathy associated with Fc receptor-like 3 polymorphism ( FCRL3 − 169 T > C ) [24]. FCRL3 is a glycoprotein of the immunoglobulin receptor superfamily, expressed in Treg cells that may play a role as a negative regulator of Treg function [40–42].…”

Section: Discussionmentioning

confidence: 99%

Genetic basis of rotator cuff injury: a systematic review

et al. 2019

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Background Rotator cuff disease is a widespread musculoskeletal pathology and a major cause of shoulder pain. Studies on familial predisposition suggest that genetic plays a role in the pathogenesis of rotator cuff disease. Several genes are responsible for rotator cuff disease. The aim of this study was to perform a systematic review on genetic association between rotator cuff disease and genes variations. Methods A systematic review of the literature was performed, in accordance with the PRISMA guidelines. PubMed, Medline, CINAHL, Cochrane, Embase and Google Scholar databases were searched comprehensively using the keywords: “Rotator cuff”, “Gene”, “Genetic”, “Predisposition”, “Single-nucleotide polymorphism” and “Genome-wide association”. Results 8 studies investigating genes variations associated with rotator cuff tears were included in this review. 6 studies were case-control studies on candidate genes and 2 studies were GWASs. A significant association between SNPs and rotator cuff disease was found for DEFB1, FGFR1, FGFR3, ESRRB, FGF10, MMP-1, TNC, FCRL3, SASH1, SAP30BP, rs71404070 located next to cadherin8. Contradictory results were reported for MMP-3. Conclusion Further investigations are warranted to identify complete genetic profiles of rotator cuff disease and to clarify the complex interaction between genes, encoded proteins and environment. This may lead to individualized strategies for prevention and treatment of rotator cuff disease. Level of evidence Level IV, Systematic Review.

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“…Single nucleotide polymorphisms (SNPs), a variation of the nucleotide at a single position in DNA sequence, involved with inflammatory process were associated as non-modifiable factors for developing tendinopathies [ 6 – 8 ]. Pro-inflammatory cytokines, such as tumor necrosis factor alpha (TNF-α), and growth factors have been implicated as a mechanism in early stages of tendinopathies [ 1 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Association of TNF-α -308G > A polymorphism with susceptibility to tendinopathy in athletes: a case–control study

Lopes

Miranda

Guimarães

et al. 2021

BMC Sports Sci Med Rehabil

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Background High levels of the tumor necrosis factor alpha (TNF-α) induce apoptosis and pro-inflammatory effects for primary degeneration of tendon and development of tendinopathy. The aim of this study was to investigate the association between the TNF-α polymorphisms and tendinopathy in athletes. Methods Two hundred and seventy athletes (135 tendinopathy cases and 135 controls) were included and genotyped (TNF-α -1031T > C; -857 C > T; -308G > A) using TaqMan validated assays. The association of the polymorphisms with tendinopathy was evaluated by a multivariate logistic regression model, using odds ratios (OR) and 95 % confidence intervals (CI). Results The variant allele − 308 A was significantly associated with patellar (OR: 1.9; 95 % CI: 1.01–3.6) or Achilles tendinopathies (OR: 2.7; 95 % CI: 1.1–6.7). No significant differences were found in allele or genotype distributions of the − 1031T > C and − 857 C > T polymorphisms between cases and controls. TNF-α TCA haplotype was associated with increased tendinopathies risk, either considering all cases (OR: 2.6, 95 % CI: 1.3–5.3), patellar (OR: 3.3, 95 % CI: 1.5–7.3), rotator cuff (OR: 3.1, 95 % CI: 1.4–7.2) or Achilles tendinopathies (OR: 3.8, 95 % CI: 1.1–12.7). Conclusions These results suggest that the TNF-α polymorphisms could influence the susceptibility to developing tendinopathy among athletes. Knowledge of the TNF-α polymorphisms associated to tendinopathy in athletes can further understanding of the inflammatory role in the early stages of the disease and contribute for sports injury surveillance programmes, in which athletes with TNF-α TCA haplotype could be early subjected to cryotherapy after training and competition to avoid tendinopathy development.

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Fc receptor-like 3 (−169T>C) polymorphism increases the risk of tendinopathy in volleyball athletes: a case control study

Cited by 23 publications

References 53 publications

Amniotic membrane-mesenchymal stromal cells secreted factors and extracellular vesicle-miRNAs: Anti-inflammatory and regenerative features for musculoskeletal tissues

Amniotic membrane-mesenchymal stromal cells secreted factors and extracellular vesicle-miRNAs: Anti-inflammatory and regenerative features for musculoskeletal tissues

Genetic basis of rotator cuff injury: a systematic review

Association of TNF-α -308G > A polymorphism with susceptibility to tendinopathy in athletes: a case–control study

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