Fc receptor—More answers, more questions

Fornůsek, L; Větvička, Václav

doi:10.1007/bf02873160

Cited by 10 publications

(1 citation statement)

References 300 publications

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“…Murine MQ, as well as MQ, derived from many other mammals have repeatedly been shown to bind different kinds of particles coated with all isotypes of Ig [8,[11][12][13][26][27][28]. However, only very limited data about simultaneous expression of two or more types of FcR have been published.…”

Section: Discussionmentioning

confidence: 99%

Co‐expression of different types of Fc receptors on murine peritoneal macrophages

Větvička¹,

Fornů²,

Kincade

et al. 1986

Eur J Immunol

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Simultaneous expression of particular immunoglobulin Fc receptors (FcR) was studied on the plasma membranes of murine peritoneal macrophages. This was facilitated by the use of sheep red blood cells (SRBC) and/or synthetic microspheres coated with monoclonal antibodies of different isotypes. It was concluded that a majority of macrophages bear more than one type of FcR; macrophages bearing at least three types of FcR were present in the peritoneal cavity; macrophages bearing Fc mu R did not bind IgE, IgA or IgG; all macrophages bearing Fc alpha R also expressed Fc gamma 2bR, Fc gamma 3R and Fc epsilon R; all macrophages bearing Fc epsilon R also expressed Fc gamma 2bR and Fc alpha R. Except for Fc alpha R, essentially equivalent numbers of FcR-bearing macrophages were detected when antibody-coated SRBC or polymeric microspheres were used. Simultaneous applications of these reagents permitted the most detailed and direct investigations yet performed of multiple FcR expression on individual cells.

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Section: Discussionmentioning

confidence: 99%

Co‐expression of different types of Fc receptors on murine peritoneal macrophages

Větvička¹,

Fornů²,

Kincade

et al. 1986

Eur J Immunol

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Detection of Fc ‘Gamma’ R-Like Material in Cerebrospinal Fluid: A Factor Modifying the Immune Reaction?

Karcher¹,

Smet²,

Frank³

et al. 1987

Cellular and Humoral Immunological Components of Cerebrospinal Fluid in Multiple Sclerosis

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Fc? receptors on keratinocytes in psoriasis

Livden

1988

Arch Dermatol Res

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Epidermis in cryostat sections of skin biopsy specimens from patients with psoriasis and from healthy individuals bound bovine erythrocytes (E) sensitized with rabbit IgG antibodies (A)(EA). No binding occurred using E or E sensitized with IgM or F(ab')2 fragments of IgG. The binding of EA was inhibited by human IgG and by Fc fragments of IgG, whereas human IgA, IgM, albumin, and F(ab)2 fragments of IgG did not inhibit the binding, indicating the presence of receptors for the Fc part of IgG (FcR). EA bound mainly to stratum spinosum and most strongly above FcR-positive cell infiltrates in dermal papillae. The binding of EA to sections from patients with active psoriasis was stronger than to sections from patients with stationary psoriasis vulgaris. Sections of unaffected skin from patients with psoriasis and healthy individuals also bound EA, but the binding was weaker than to sections of psoriatic lesions. The receptors were sensitive to periodic acid, formaldehyde, and heat. Using immune complexes of horseradish peroxidase (HRP) and rabbit IgG antibodies to HRP, the receptors were localized to the outer aspect of the keratinocytes and to the inflammatory cells in the microabscesses. The strongest binding occurred in the same areas which adhered EA most strongly. FcR on dendritic epidermal cells could not be demonstrated in situ. A monoclonal antibody against FcR also stained the outer aspect of most keratinocytes throughout the epidermis. FcR on keratinocytes support the assumption that these cells contribute to immune reactions in the skin.

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Fc receptor—More answers, more questions

Cited by 10 publications

References 300 publications

Co‐expression of different types of Fc receptors on murine peritoneal macrophages

Co‐expression of different types of Fc receptors on murine peritoneal macrophages

Detection of Fc ‘Gamma’ R-Like Material in Cerebrospinal Fluid: A Factor Modifying the Immune Reaction?

Fc? receptors on keratinocytes in psoriasis

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