1997
DOI: 10.1074/jbc.272.8.4753
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Fcγ Receptor I Activation Triggers a Novel Ca2+-activated Current Selective for Monovalent Cations in the Human Monocytic Cell Line, U937

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Cited by 9 publications
(7 citation statements)
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“…However, the mechanism of the increased excitability of DRG neurons remains to be determined. In macrophages and monocytes, the activation of FcγRI triggers a Ca 2+ -dependent, nonselective cation channel which is mainly permeable to Na + and induces membrane depolarization (Floto et al, 1997; Nelson et al, 1985; Young et al, 1983). It is possible that IC activates a nonselective cation channel in DRG neurons that contributes to the decrease in input resistance, lower rheobase, and membrane potential depolarization.…”
Section: Discussionmentioning
confidence: 99%
“…However, the mechanism of the increased excitability of DRG neurons remains to be determined. In macrophages and monocytes, the activation of FcγRI triggers a Ca 2+ -dependent, nonselective cation channel which is mainly permeable to Na + and induces membrane depolarization (Floto et al, 1997; Nelson et al, 1985; Young et al, 1983). It is possible that IC activates a nonselective cation channel in DRG neurons that contributes to the decrease in input resistance, lower rheobase, and membrane potential depolarization.…”
Section: Discussionmentioning
confidence: 99%
“…In the human monocytic cell line, FcγRI activation indirectly triggered a non-selective cation channel (NSCC) (Floto et al, 1997). Furthermore, the activity of this channel was enhanced by the depletion of intracellular Ca 2+ stores independently of FcγRI, suggesting the involvement of a store-operated channel (SOC).…”
Section: Introductionmentioning
confidence: 99%
“…The FceRImediated Ca 2+ signal can be suppressed using a competitive SK inhibitor, without affecting Syk tyrosine kinase activation and the low-level production of IP 3 (Daeron 1997). Furthermore, the aggregation of FccRI in IFN-c-treated monocytes mobilizes a transient release of stored Ca 2+ that involves the activation of phospholipase D and results in the downstream activation of SK (Floto et al 1997;Melendez et al 1998;Nunes and Demaurex 2010).…”
Section: Activating Fcrsmentioning
confidence: 98%