FcμR (Toso/Faim3) is not an inhibitor of Fas-mediated cell death in mouse T and B cells

Ouchida, Rika; Mori, Hiromi; Ohno, Hiroshi; Wang, Ji‐Yang

doi:10.1182/blood-2012-12-470906

Cited by 5 publications

(3 citation statements)

References 11 publications

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“…More recently, however, several studies identified FAIM3 as the long elusive Fc-receptor for IgM that is expressed on the cell surface of human and mouse primary follicular B cells. Those studies failed to find evidence for a Fas-inhibitory activity on these cells 4 , 5 . They therefore renamed the molecule “FcμR”.…”

Section: Introductionmentioning

confidence: 95%

The IgM receptor FcμR limits tonic BCR signaling by regulating expression of the IgM BCR

et al. 2017

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The IgM Fc receptor (FcμR), originally cloned as “Fas-apoptosis inhibitory molecule (FAIM3/TOSO)” can function as a cell surface receptor for secreted IgM on a variety of cell types. We report that FcμR also is expressed in the trans-Golgi network of developing B cells, where it constrains IgM- but not IgD-BCR transport. In FcμR absence, IgM-BCR surface expression was increased, resulting in enhanced tonic BCR signaling. B cell-specific FcμR-deficiency enhanced spontaneous differentiation of B-1 cells, resulting in increases in natural IgM levels, and dysregulated B-2 cell homeostasis, causing spontaneous germinal center formation, increased serum autoantibody titers, and excessive B cell accumulation. Thus, FcμR/FAIM3 is a critical regulator of B cell biology by constraining IgM-BCR transport and cell surface expression.

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Section: Introductionmentioning

confidence: 95%

The IgM receptor FcμR limits tonic BCR signaling by regulating expression of the IgM BCR

et al. 2017

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“…In contrast, Fcα/μR is expressed by macrophages, B cells, intestinal lamina propria and several other cell types (35), and pIgR is mainly expressed on the intestinal epithelial cells (4, 5). Although FcμR was originally designated as Fas apoptotic inhibitory molecule 3 or TOSO (37), it is now clear that both human and mouse FcμR have no inhibitory activity against Fas-mediated apoptosis (38, 39).…”

Section: Molecular Characteristics Of Fcμrmentioning

confidence: 99%

Role of the IgM Fc Receptor in Immunity and Tolerance

et al. 2019

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Immunoglobulin (Ig) M is the first antibody isotype to appear during evolution, ontogeny and immune responses. IgM not only serves as the first line of host defense against infections but also plays an important role in immune regulation and immunological tolerance. For many years, IgM is thought to function by binding to antigen and activating complement system. With the discovery of the IgM Fc receptor (FcμR), it is now clear that IgM can also elicit its function through FcμR. In this review, we will describe the molecular characteristics of FcμR, its role in B cell development, maturation and activation, humoral immune responses, host defense, and immunological tolerance. We will also discuss the functional relationship between IgM-complement and IgM-FcμR pathways in regulating immunity and tolerance. Finally, we will discuss the potential involvement of FcμR in human diseases.

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“…In 2013, Ouchida et al (20) in Wang's laboratory showed that FcmR was not involved in Fas-mediated cell death in thymocytes or in splenic T and B cells before and after activation, because there were no differences in FasL-or agonistic IgG mAb-induced apoptosis between wild-type and Fcmrdeficient mice. Also in 2013, Ding et al (21) …”

Section: Nomenclature Of Toso Fas Apoptosis Inhibitory Molecule 3 Amentioning

confidence: 99%

Nomenclature of Toso, Fas Apoptosis Inhibitory Molecule 3, and IgM FcR

Kubagawa

Carroll

Jacob

et al. 2015

The Journal of Immunology

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Hiromi Kubagawa and John E. Coligan coordinated an online meeting to define an appropriate nomenclature for the cell surface glycoprotein presently designated by different names: Toso, Fas apoptosis inhibitory molecule 3 (FAIM3), and IgM FcR (FcμR). FAIM3 and Faim3 are the currently approved symbols for the human and mouse genes, respectively, in the National Center for Biotechnology Information, Ensembl, and other databases. However, recent functional results reported by several groups of investigators strongly support a recommendation for renaming FAIM3/Faim3 as FCMR/Fcmr, a name better reflecting its physiological function as the FcR for IgM. Participants included 12 investigators involved in studying Toso/FAIM3(Faim3)/FμR, representatives from the Human Genome Nomenclature Committee (Ruth Seal) and the Mouse Genome Nomenclature Committee (Monica McAndrews), and an observer from the IgM research field (Michael Carroll). In this article, we provide a brief background of the key research on the Toso/FAIM3(Faim3)/FcμR proteins, focusing on the ligand specificity and functional activity, followed by a brief summary of discussion about adopting a single name for this molecule and its gene and a resulting recommendation for genome nomenclature committees.

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FcμR (Toso/Faim3) is not an inhibitor of Fas-mediated cell death in mouse T and B cells

Cited by 5 publications

References 11 publications

The IgM receptor FcμR limits tonic BCR signaling by regulating expression of the IgM BCR

The IgM receptor FcμR limits tonic BCR signaling by regulating expression of the IgM BCR

Role of the IgM Fc Receptor in Immunity and Tolerance

Nomenclature of Toso, Fas Apoptosis Inhibitory Molecule 3, and IgM FcR

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