FDCSP Is an Immune-Associated Prognostic Biomarker in HPV-Positive Head and Neck Squamous Carcinoma

Wu, Qimeng; Shao, Ting-ru; Huang, Guangzhao; Zheng, Zenan; Jiang, Yingtong; Zeng, Weisen; Lv, Xiaoyang

doi:10.3390/biom12101458

Cited by 6 publications

(4 citation statements)

References 54 publications

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“…FDCSP expression was reported to be related to TP53 mutational status and chemokine pathways. High expression of this gene was favorable for the prognosis of patients with HPV+ HNSCC [ 30 ]. JCHAIN, PGLYRP4 and SPINK6 had been reported as protective factors for HNSCC patients, consistent with the results in this study [ 31 – 33 ].…”

Section: Discussionmentioning

confidence: 99%

A novel oxidative stress-related gene signature as an indicator of prognosis and immunotherapy responses in HNSCC

Li,

Zheng,

Liu

et al. 2023

Aging

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Purpose: To identify molecular subtypes of oxidative stress-related genes in head and neck squamous cell carcinoma (HNSCC) and to construct a scoring model of oxidative stress-related genes. Methods: R language based scRNA-seq and bulk RNA-seq analyses were used to identify molecular isoforms of oxidative stress-related genes in HNSCC. An oxidative stress-related gene scoring (OSRS) model was constructed, which were verified through online data and immunohistochemical staining of clinical samples. Results: Using TCGA-HNSCC datasets, nine predictive genes for overall patient survival, rarely reported in previous similar studies, were screened. AREG and CES1 were identified as prognostic risk factors. CSTA, FDCSP, JCHAIN, IFFO2, PGLYRP4, SPOCK2 and SPINK6 were identified as prognostic factors. Collectively, all genes formed a prognostic risk signature model for oxidative stress in HNSCC, which were validated in GSE41613, GSE103322 and PRJEB23709 datasets. Immunohistochemical staining of SPINK6 in nasopharyngeal cancer samples validated the gene panel. Subsequent analysis indicated that subgroups of the oxidative stress prognostic signature played important roles during cellular communication, the immune microenvironment, the differential activation of transcription factors, oxidative stress and immunotherapeutic responses. Conclusions: The risk model might predict HNSCC prognosis and immunotherapeutic responses.

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Section: Discussionmentioning

confidence: 99%

A novel oxidative stress-related gene signature as an indicator of prognosis and immunotherapy responses in HNSCC

Li,

Zheng,

Liu

et al. 2023

Aging

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“…HPV-positive samples with high expression of FDCSP are enriched in follicular helper T, memory B cells, CD8+ T cells, memory CD4+ cells and macrophages. It was also observed that elevated FDCSP levels and CD8+ T cell abundance were associated with better prognosis in HPV-positive HNSCC with increasing OS [50].…”

Section: Mrnasmentioning

confidence: 90%

“…Importantly, in our literature review, an NEFH (neurofilament heavy chain) transcript was identified in two studies (Table 1). In one of them, NEFH is part of a molecular signature of eight high-risk genes for decreased survival in patients with HPV-positive HNSCC [45]; while in the second study, high NEFH expression was associated with better OS in HPV-positive HNSCC [50]. However, given that both studies have a limited number of samples and diverse analytical strategies, it cannot be assumed that NEFH is one of the most promising prognostic biomarker candidates in HPV-positive HNSCC, so further evidence to support this claim is required.…”

Section: Mrnasmentioning

confidence: 99%

Potential Transcript-Based Biomarkers Predicting Clinical Outcomes of HPV-Positive Head and Neck Squamous Cell Carcinoma Patients

Muñoz-Bello,

Romero-Córdoba,

García-Chávez

et al. 2024

Cells

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Human papillomavirus (HPV)-positive Head and Neck Squamous Cell Carcinomas (HNSCC) comprise a particular cancer entity traditionally associated with better clinical outcomes. Around 25% of HNSCC are HPV positive, HPV16 being the most prevalent type. Nevertheless, close to 30% of the HPV-positive patients have an unfavorable prognosis, revealing that this type of tumor exhibits great heterogeneity leading to different clinical behaviors. Efforts have been made to identify RNA molecules with prognostic value associated with the clinical outcome of patients with HPV-positive HNSCC, with the aim of identifying patients at high risk of metastasis, disease recurrence, and poor survival, who would require closer clinical follow-up and timely intervention. Moreover, the molecular identification of those HPV-positive HNSCC patients with good prognosis will allow the implementation of de-escalating therapeutic strategies, aiming to reduce side effects, resulting in a better quality of life. This review compiles a series of recent studies addressing different methodological and conceptual approaches aimed at searching for potential gene expression-based biomarkers associated with the prognosis of patients with HPV-positive HNSCC.

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“…Head and neck cancer is a malignant tumor with a high global incidence, ranking as the sixth most common cancer worldwide [1][2][3]. The occurrence of head and neck cancer is highly correlated with smoking, alcoholism and HPV infection [4][5][6]. Over 90% of head and neck cancers are squamous cell carcinomas [7].…”

Section: Introductionmentioning

confidence: 99%

Molecular Evolutionary Landscape of the Immune Microenvironment of Head and Neck Cancer

et al. 2023

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Head and neck cancer is a highly heterogeneous malignant tumor. Numerous studies have shown that the immune microenvironment of head and neck cancer has a significant impact on its occurrence and development, as well as its prognosis. However, there have been fewer studies related to the accurate immunophenotyping of head and neck cancer. In this study, we used gene expression profile information and clinical information from the TCGA-HNSC cohort (502 samples) and the GSE655858 cohort (270 samples) to identify and independently validate three immune subtypes (Cluster1–Cluster3) with different immune-related molecular profiles and clinical outcomes. Cluster2, which is mainly dominated by B-lymphocyte infiltration, was found to have the best prognosis. In addition, a support vector machine (SVM)-based classifier was constructed, which could accurately classify HNSC based on 19 genes. Furthermore, the results of the prognostic analysis showed activation of antibody-secreting B-lymphocyte function, which showed a good prognostic effect in all three immune subtypes of HNSC. Finally, the immune evolutionary landscape of HNSC was constructed in an attempt to explain the evolutionary pattern of the immune subtypes of HNSC. In summary, we provide a conceptual framework for understanding the tumor immune microenvironment in HNSC and demonstrate the importance of immune infiltration of B lymphocytes in HNSC. Further research is needed to assess the importance of these immunophenotypes in combination drug therapy and to provide a basis for screening appropriate patients for immunotherapy.

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FDCSP Is an Immune-Associated Prognostic Biomarker in HPV-Positive Head and Neck Squamous Carcinoma

Cited by 6 publications

References 54 publications

A novel oxidative stress-related gene signature as an indicator of prognosis and immunotherapy responses in HNSCC

A novel oxidative stress-related gene signature as an indicator of prognosis and immunotherapy responses in HNSCC

Potential Transcript-Based Biomarkers Predicting Clinical Outcomes of HPV-Positive Head and Neck Squamous Cell Carcinoma Patients

Molecular Evolutionary Landscape of the Immune Microenvironment of Head and Neck Cancer

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