FDG PET/CT and Diffusion-Weighted Imaging of Head and Neck Squamous Cell Carcinoma

Nakajo, Masatoyo; Nakajo, Masayuki; Kajiya, Yoriko; Tani, Akio; Kamiyama, Takuro; Yonekura, Ryuji; Fukukura, Yoshihiko; Matsuzaki, Tsutomu; Nishimoto, Katsutaro; Nomoto, Mitsuharu; Koriyama, Chihaya

doi:10.1097/rlu.0b013e318248524a

Cited by 65 publications

(36 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, Rakheja et al found statistically significant inverse correlations between maximum SUVs and minimum ADC values and mean SUVs and mean ADC values in 69 [ 18 F] FDG avid malignant lesions derived from simultaneous FDG PET/MRI [17]. Nakajo et al report of significant inverse correlations of maximum SUVs derived from FDG PET/CT and ADC values in squamous cell carcinoma of the head and neck region [18]. However, there are also reports revealing that SUVs and ADC values do not inversely correlate significantly, as for example shown by Varoquaux et al in a study about head and neck squamous cell carcinoma [19].…”

Section: Discussionmentioning

confidence: 99%

Combined PET Imaging and Diffusion-Weighted Imaging of Intermediate and High-Risk Primary Prostate Carcinomas with Simultaneous [18F] Choline PET/MRI

et al. 2014

View full text Add to dashboard Cite

PurposeTo characterize intermediate and high-risk prostate carcinomas with measurements of standardized uptake values (SUVs) and apparent diffusion coefficient (ADC) values by means of simultaneous [18F] choline PET/MRI.Materials and Methods35 patients with primary prostate cancer underwent simultaneous [18F] choline PET/MRI. From these, 21 patients with an intermediate and high risk constellation who were not under ongoing hormonal therapy were included. Altogether 32 tumor lesions with a focal uptake of [18F] choline could be identified. Average ADC values (ADCaver) minimum ADC values (ADCmin) as well as maximum and mean SUVs (SUVmax, SUVmean) of tumor lesions were assessed with volume-of-interest (VOI) and Region-of-interest (ROI) measurements. As a reference, also ADCaver, ADCmin and SUVmax and SUVmean of non-tumorous prostate tissue were measured. Statistical analysis comprised calculation of descriptive parameters and calculation of Pearson’s product moment correlations between ADC values and SUVs of tumor lesions.ResultsMean ADCaver and ADCmin of tumor lesions were 0.94±0.22×10−3 mm2/s and 0.65±0.21×10−3 mm2/s, respectively. Mean SUVmax and SUVmean of tumor lesions were 6.3±2.3 and 2.6±0.8, respectively. These values were in each case significantly different from the reference values (p<0.001). There was no significant correlation between the measured SUVs and ADC values (SUVmax vs. ADCaver: R = −0.24, p = 0.179; SUVmax vs. ADCmin: R = −0.03, p = 0.877; SUVmean vs. ADCaver: R = −0.27, p = 0.136; SUVmean vs. ADCmin: R = −0.08, p = 0.679).ConclusionBoth SUVs and ADC values differ significantly between tumor lesions and healthy tissue. However, there is no significant correlation between these two parameters. This might be explained by the fact that SUVs and ADC values characterize different parts of tumor biology.

show abstract

Section: Discussionmentioning

confidence: 99%

Combined PET Imaging and Diffusion-Weighted Imaging of Intermediate and High-Risk Primary Prostate Carcinomas with Simultaneous [18F] Choline PET/MRI

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Recent studies have demonstrated for head and neck cancers that SUVmax is inversely correlated to ADC ratio between different b-values [39] or ADC ratio between minimum and mean [40]. However, Nakajo and co-authors have shown a negative and significant correlation between SUVmax and ADC mean, studying 26 patients with HNSCC before treatment [41]. Our results are probably different due to the fact that our population is heterogenous (as it is in any clinical routine), including different histologic types of HNC and not only primary tumors.…”

Section: Pet Values and Dwi Parametersmentioning

confidence: 91%

Use of diffusion-weighted imaging (DWI) in PET/MRI for head and neck cancer evaluation

Queiroz

Hüllner

Kuhn

et al. 2014

Eur J Nucl Med Mol Imaging

View full text Add to dashboard Cite

show abstract

“…Recently there have been few reports showing correlations between these multimodality imaging techniques and their initial role in the prognosis of HNSCC patients[15]. However, there are limited studies initiated to explore the use of these techniques together in a treatment planning setting for radiation oncology[16].…”

Section: Introductionmentioning

confidence: 99%

Multimodality functional imaging using DW-MRI and ¹⁸F-FDG-PET/CT during radiation therapy for human papillomavirus negative head and neck squamous cell carcinoma: Meixoeiro Hospital of Vigo Experience

Nuñez¹,

Medina²,

Iglesias³

et al. 2017

WJR

View full text Add to dashboard Cite

AIMTo noninvasively investigate tumor cellularity measured using diffusion-weighted magnetic resonance imaging (DW-MRI) and glucose metabolism measured by 18F-labeled fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) during radiation therapy (RT) for human papillomavirus negative (HPV-) head and neck squamous cell carcinoma (HNSCC).METHODSIn this prospective study, 6 HPV- HNSCC patients underwent a total of 34 multimodality imaging examinations DW-MRI at 1.5 T Philips MRI scanner [(n = 24) pre-, during- (2-3 wk), and post-treatment (Tx), and 18F-FDG PET/CT pre- and post-Tx (n = 10)]. All patients received RT. Monoexponential modeling of the DW-MRI data yielded the imaging metric apparent diffusion coefficient (ADC) and the mean of standardized uptake value (SUV) was measured from 18F-FDG PET uptake. All patients had a clinical follow-up as the standard of care and survival status was documented at 1 year.RESULTSThere was a strong negative correlation between the mean of pretreatment ADC (ρ = -0.67, P = 0.01) and the pretreatment 18F-FDG PET SUV. The percentage (%) change in delta (∆) ADC for primary tumors and neck nodal metastases between pre- and Wk2-3 Tx were as follows: 75.4% and 61.6%, respectively, for the patient with no evidence of disease, 27.5% and 32.7%, respectively, for those patients who were alive with disease, and 26.9% and 7.31%, respectively, for those who were dead with disease.CONCLUSIONThese results are preliminary in nature and are indicative, and not definitive, trends rendered by the imaging metrics due to the small sample size of HPV- HNSCC patients in a Meixoeiro Hospital of Vigo Experience.

show abstract

FDG PET/CT and Diffusion-Weighted Imaging of Head and Neck Squamous Cell Carcinoma

Abstract: These results suggest that pretreatment primary tumor SUV(max) and ADC correlate significantly and negatively and both may have similar potential to predict DFS or disease events of HNSCC.

Cited by 65 publications

References 27 publications

Combined PET Imaging and Diffusion-Weighted Imaging of Intermediate and High-Risk Primary Prostate Carcinomas with Simultaneous [18F] Choline PET/MRI

Combined PET Imaging and Diffusion-Weighted Imaging of Intermediate and High-Risk Primary Prostate Carcinomas with Simultaneous [18F] Choline PET/MRI

Use of diffusion-weighted imaging (DWI) in PET/MRI for head and neck cancer evaluation

Multimodality functional imaging using DW-MRI and ¹⁸F-FDG-PET/CT during radiation therapy for human papillomavirus negative head and neck squamous cell carcinoma: Meixoeiro Hospital of Vigo Experience

Contact Info

Product

Resources

About

FDG PET/CT and Diffusion-Weighted Imaging of Head and Neck Squamous Cell Carcinoma

Abstract: These results suggest that pretreatment primary tumor SUV(max) and ADC correlate significantly and negatively and both may have similar potential to predict DFS or disease events of HNSCC.

Cited by 65 publications

References 27 publications

Combined PET Imaging and Diffusion-Weighted Imaging of Intermediate and High-Risk Primary Prostate Carcinomas with Simultaneous [18F] Choline PET/MRI

Combined PET Imaging and Diffusion-Weighted Imaging of Intermediate and High-Risk Primary Prostate Carcinomas with Simultaneous [18F] Choline PET/MRI

Use of diffusion-weighted imaging (DWI) in PET/MRI for head and neck cancer evaluation

Multimodality functional imaging using DW-MRI and 18F-FDG-PET/CT during radiation therapy for human papillomavirus negative head and neck squamous cell carcinoma: Meixoeiro Hospital of Vigo Experience

Contact Info

Product

Resources

About

Multimodality functional imaging using DW-MRI and ¹⁸F-FDG-PET/CT during radiation therapy for human papillomavirus negative head and neck squamous cell carcinoma: Meixoeiro Hospital of Vigo Experience