FDG-PET detects nonuniform muscle activity in the lower body during human gait

Kindred, John H.; Ketelhut, Nathaniel B.; Benson, John-Michael; Rudroff, Thorsten

doi:10.1002/mus.25116

Cited by 2 publications

(2 citation statements)

References 56 publications

(82 reference statements)

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“…Muscular activity cannot, however, be assumed to be homogeneous throughout a given muscle [ 8 , 34 ]. As also found in previous studies, our results show that even though quadriceps were activated using a strictly controlled paradigm, there was a large variation in the measured activation among subjects, among individual muscle groups and even within a muscle [ 19 – 21 , 35 ]. However, the correlation between relΔ T 2 and relGU was found to be consistent in voxel by voxel comparisons and displayed the same inhomogeneous activation patterns.…”

Section: Discussionsupporting

confidence: 87%

Assessment of muscle function using hybrid PET/MRI: comparison of 18F-FDG PET and T2-weighted MRI for quantifying muscle activation in human subjects

Haddock

Holm

Poulsen

et al. 2016

Eur J Nucl Med Mol Imaging

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PurposeThe aim of this study was to determine the relationship between relative glucose uptake and MRI T 2 changes in skeletal muscles following resistance exercise using simultaneous PET/MRI scans.MethodsTen young healthy recreationally active men (age 21 – 28 years) were injected with 18F-FDG while activating the quadriceps of one leg with repeated knee extension exercises followed by hand-grip exercises for one arm. Immediately following the exercises, the subjects were scanned simultaneously with 18F-FDG PET/MRI and muscle groups were evaluated for increases in 18F-FDG uptake and MRI T 2 values.ResultsA significant linear correlation between 18F-FDG uptake and changes in muscle T 2 (R 2 = 0.71) was found. for both small and large muscles and in voxel to voxel comparisons. Despite large intersubject differences in muscle recruitment, the linear correlation between 18F-FDG uptake and changes in muscle T 2 did not vary among subjects.ConclusionThis is the first assessment of skeletal muscle activation using hybrid PET/MRI and the first study to demonstrate a high correlation between 18F-FDG uptake and changes in muscle T 2 with physical exercise. Accordingly, it seems that changes in muscle T 2 may be used as a surrogate marker for glucose uptake and lead to an improved insight into the metabolic changes that occur with muscle activation. Such knowledge may lead to improved treatment strategies in patients with neuromuscular pathologies such as stroke, spinal cord injuries and muscular dystrophies.

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Section: Discussionsupporting

confidence: 87%

Assessment of muscle function using hybrid PET/MRI: comparison of 18F-FDG PET and T2-weighted MRI for quantifying muscle activation in human subjects

Haddock

Holm

Poulsen

et al. 2016

Eur J Nucl Med Mol Imaging

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“…These studies found, for example, that the muscles in the lower leg were more active than those in the thigh and around the hip, and that FDG-PET could be used to assess muscle activity in deep muscles such as the gluteus minimus, iliacus, and tibialis posterior, which had previously been difficult to measure using surface electromyography [19, 20, 23]. However limited data on asymmetries between muscles in the left and right legs, and region-specific activation within muscles are available [22, 24, 25]. In part, this may have been due to the analyses of the FDG uptake data being limited to single slices of the PET scan, instead of taking the uptake in the entire muscle into account.…”

Section: Introductionmentioning

confidence: 99%

Symmetry and spatial distribution of muscle glucose uptake in the lower limbs during walking measured using FDG-PET

Kolk¹,

Klawer²,

Visser

et al. 2019

PLoS ONE

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Purpose This study aimed to elucidate whether muscle activity (in terms of glucose uptake) between the legs can be considered symmetrical during walking. Furthermore, we aimed to determine whether the [ 18 F]-fluorodeoxyglucose was distributed heterogeneously throughout each muscle, and if so, whether areas of high uptake would be clustered. Methods Ten healthy participants walked on a treadmill at self-selected comfortable walking speed for a total of 90 minutes, 60 minutes before and 30 minutes after intravenous injection of 50 MBq [ 18 F]-fluorodeoxyglucose. Thereafter, a positron emission tomography/computed tomography scan of the lower limb was acquired. Three-dimensional muscle contours of 78 (= 39x2) muscles of the left and right lower limb were semi-automatically determined from magnetic resonance imaging scans. After non-rigid registration, those muscle contours were used to extract [ 18 F]-fluorodeoxyglucose uptake from the positron emission tomography scans. Results Large asymmetries were observed in the lower leg muscles (e.g. median absolute asymmetry index of 42% in the gastrocnemius medialis) and in the gluteus minimus (30% asymmetry) and gluteus medius (15% asymmetry), whereas the uptake in the thighs was relatively symmetrical between the limbs (<6% asymmetry). These were not related to limb-dominance nor to inter-limb differences in muscle volume. The [ 18 F]-fluorodeoxyglucose distribution was not distributed normally; most voxels had a relatively low standardized uptake value, and a minority of voxels had a relatively high standardized uptake value. The voxels with higher [ 18 F]-fluorodeoxyglucose uptake were distributed heterogeneously; they were clustered in virtually all muscles. Conclusion The findings in this study challenge the common assumption of symmetry in muscle activity between the limbs in healthy subjects. The clustering of voxels with high uptake suggests that even in this prolonged repetitive task, different spatial regions of muscles contribute differently to walking than others.

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FDG-PET detects nonuniform muscle activity in the lower body during human gait

Cited by 2 publications

References 56 publications

Assessment of muscle function using hybrid PET/MRI: comparison of 18F-FDG PET and T2-weighted MRI for quantifying muscle activation in human subjects

Assessment of muscle function using hybrid PET/MRI: comparison of 18F-FDG PET and T2-weighted MRI for quantifying muscle activation in human subjects

Symmetry and spatial distribution of muscle glucose uptake in the lower limbs during walking measured using FDG-PET

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