FDG PET imaging of paragangliomas of the neck: comparison with MIBG SPET

Macfarlane, David; Shulkin, Barry L.; Murphy, Kieran J.; Wolf, Gregory T.

doi:10.1007/bf00801625

Cited by 20 publications

(5 citation statements)

References 6 publications

(5 reference statements)

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“…Positron emission tomography (PET) studies have not been done in these patients, though case reports indicate that paragangliomas have been successfully detected by PET with 18 F-fluorodeoxyglucose [36,37] or 18 F-DOPA [38].…”

Section: Discussionmentioning

confidence: 99%

Clinical value of somatostatin receptor imaging in patients with suspected head and neck paragangliomas

Schmidt

Fischer

Dietlein

et al. 2002

European Journal of Nuclear Medicine and Molecular Imaging

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Paragangliomas or glomus tumours of the head and neck region are rare somatostatin receptor-expressing neuroendocrine tumours. Precise preoperative diagnosis is of special importance in order to adequately weigh the potential benefit of the operation against the inherent risks of the procedure. In this study, the clinical value of somatostatin receptor imaging was assessed in 19 patients who underwent somatostatin receptor scintigraphy because of known or suspected paraganglioma of the head and neck region. The results were compared with the results of computed tomography and/or magnetic resonance imaging, histology and clinical follow-up. [(111)In-DTPA- D-Phe(1)]-octreotide scintigraphy was performed 4-6 and 24 h after i.v. injection of 140-220 MBq (111)In-octreotide. Whole-body and planar images as well as single-photon emission tomography images were acquired and lesions were graded according to qualitative tracer uptake. Somatostatin receptor imaging was positive in nine patients, identifying paragangliomas for the first time in three patients and recurrent disease in six patients. In one patient, a second, previously unknown paraganglioma site was identified. Negative results were obtained in ten patients. These patients included one suffering from chronic hyperplastic otitis externa, one with granuloma tissue and an organised haematoma, one with an acoustic neuroma, one with an asymmetric internal carotid artery, two with ectasia of the bulbus venae jugularis and one with a jugular vein thrombosis. In two patients with a strong family history of paraganglioma, individual involvement could be excluded. In only one patient did somatostatin receptor imaging and magnetic resonance imaging yield false negative results in respect of recurrent paraganglioma tissue. It is concluded that somatostatin receptor scintigraphy provides important information in patients with suspected paragangliomas of the head and neck region and has a strong impact on further therapeutic management.

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Section: Discussionmentioning

confidence: 99%

Clinical value of somatostatin receptor imaging in patients with suspected head and neck paragangliomas

Schmidt

Fischer

Dietlein

et al. 2002

European Journal of Nuclear Medicine and Molecular Imaging

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“…14 The PET scan has been shown to be useful for the localization of pheochromocytomas that are negative by metaiodobenzylguanidine (MIBG) scan. 9,15 Limited experience has been gained in the chemotherapy of paragangliomas. 16 When isolated metastases are present, metastatectomy should be considered.…”

Section: Discussionmentioning

confidence: 99%

PET Scan Assessment of Chemotherapy Response in Metastatic Paraganglioma

Argiris¹,

Mellott²,

Spies³

2003

American Journal of Clinical Oncology

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Paragangliomas are indolent tumors that arise from the chief cells of the paraganglia in the head and neck, mediastinum, and retroperitoneal regions. Less than 10% of paragangliomas metastasize. Paragangliomas are known to regress slowly and usually partially after radiation therapy, which has been attributed to the development of fibrosis within the abundant vascular elements of the tumor. Positron emission tomography (PET) scanning was used to monitor a 33-year-old woman with recurrent paraganglioma of the carotid body with lung and bone metastases before and after chemotherapy with cyclophosphamide, doxorubicin (Adriamycin), and dacarbazine. The patient derived clinical benefit from chemotherapy, with marked improvement of her systemic and respiratory symptoms, improvement of cancer-related anemia, and normalization of chromogranin A levels. A response was demonstrated on PET scan with decreased [18F] fluoro-2-deoxy-d-glucose uptake after chemotherapy, but no significant changes were detected on serial computed tomography (CT) scans. The patient has remained free of disease progression 24 months after chemotherapy completion. It is suggested that metabolic imaging with PET scans is superior to anatomical imaging with CT scans for the monitoring of patients with paragangliomas.

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“…Metaiodobenzylguanidine (MIBG) scintigraphy is one type of functional imaging that can be used to evaluate multiple or metastatic paragangliomas and paragangliomas in unusual locations. 24,25 Sood et al 26 reported a patient with an occult extra-adrenal para-aortic pheochromocytoma; this tumor was detected by FDG-PET but was missed by other imaging methods. 21 Currently, positron emission tomography (PET) scanning using various radiotracers including 18F-FDG glucose is widely used in oncology.…”

Section: Discussionmentioning

confidence: 99%

A Case of Extra-Adrenal Paraganglioma Localized in Retroperitoneum Diagnosed With FDG-PET

Öztürk¹,

Coşkun²,

Yaman³

et al. 2010

The Endocrinologist

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Paragangliomas are extremely rare chromaffin cell tumors arising from neural crest cells. Extra-adrenal paragangliomas originate from paravertebral and para-aortic paragangliomas distributed from the skull base to the pelvic floor. Here, we report a 57-year-old woman who presented with abdominal pain. Computed tomography revealed a solid mass at the renal hilum. The extent of disease was evaluated with 2-͓18F͔-fluoro-2-deoxy-Dglucose positron emission tomography (FDG-PET). Increased uptake of 18F-FDG was observed in the mass. The patient underwent diagnostic laparotomy, but the tumor was unresectable due to its close relationship with vascular structures. Pathologic examination confirmed that the tumor was a benign paraganglioma. To our knowledge, this location is extremely rare, and there are limited data reporting the value of PET scanning in the diagnosis of paragangliomas.

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FDG PET imaging of paragangliomas of the neck: comparison with MIBG SPET

Cited by 20 publications

References 6 publications

Clinical value of somatostatin receptor imaging in patients with suspected head and neck paragangliomas

Clinical value of somatostatin receptor imaging in patients with suspected head and neck paragangliomas

PET Scan Assessment of Chemotherapy Response in Metastatic Paraganglioma

A Case of Extra-Adrenal Paraganglioma Localized in Retroperitoneum Diagnosed With FDG-PET

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