FDG-PET positive pilomatrixoma — reconsidering multicentricity in Langerhans cell histiocytosis

Abstract

We report a case of a woman who underwent a curative resection of an upper jaw tumor histologically verified as eosinophilic granuloma. To exclude possible multiorgan involvement, PET/CT imaging was performed and revealed a metabolically active, partially calcified lesion located on the chest wall surface and clinically corresponding to a gradually developing, round, subcutaneous infiltrate with erythematous overlying skin. After complete extirpation, the pathological finding was consistent with pilomatrixoma surprisingly, thus dismissing the suspected diagnosis of multi-system Langerhans cell histiocytosis.

Pilomatricoma on 18F-fluorodeoxyglucose positron emission tomography-computed tomography: Peripheral mimic of an aggressive soft-tissue malignancy

“…[1] Our case adds to the increasing body of evidence to suggest that pilomatricomas are significantly FDG avid, [7] with a July 2020 PUBMED literature search using the keywords "Pilomatricoma" and "PET" retrieving four articles reporting on four adult patients with benign pilomatricoma. [8][9][10][11] Unlike our case, all of these tumors presented more typically for pilomatricoma as a slowly growing mass of the upper body but crucially they all demonstrated FDG avidity (SUVmax ranging from 3.86 to 16.5). This makes PET/CT staging beneficial in the management of pilomatricomas; [2] hence, the detection of these metastases by PET/CT may be the only indication that the tumor is malignant due to its ability to detect early and therefore treatable metastases.…”

18F-fluorodeoxyglucose positron emission tomography/computed tomography for primary thyroid langerhans histiocytosis: A case report and literature review

“…Few cases of the primary thyroid LCH showed in FDG PET/CT have been reported. [ 10 11 12 ] In the patient of this case, the thyroid involved LCH was the first symptoms, and clinical considered as thyroid cancer. However, the result of biopsy pathology was thyroid LCH.…”