FDG-PET scan shows increased cerebral blood flow in rat after sublingual glycine application

Blagosklonov, Oleg; Podoprigora, G. I.; Davani, Siamak; Nartsissov, Yaroslav R.; Comas, Laurent; Boulahdour, Hatem; Cardot, J

doi:10.1016/j.nima.2006.10.022

Cited by 8 publications

(2 citation statements)

References 9 publications

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“…Previous studies revealed that glycine causes pial arteriolar dilation in rats [4]. Glycine probably has a systemic effect, which is confirmed by the distribution of fluorodeoxyglucose (positron emission tomography and computer tomography, PET-CT) [6].…”

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confidence: 64%

Effect of Glycine on the Microcirculation in Rat Mesenteric Vessels

Podoprigora

Nartsissov

2009

Bull Exp Biol Med

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Model experiments on biomicroscopy of mesenteric microvessels in laboratory rats were performed to evaluate the effect of natural metabolites (e.g., amino acid glycine) on the microcirculation. The effect of glycine was determined from a change in the diameter of arterioles. Application of glycine (0.1 ml, 1 M) to the mesenteric surface was followed by arteriolar dilation (by 50-80%). Histamine-induced disturbances in the microcirculation were not observed after preapplication of glycine. Under these conditions, pretreatment with histamine was accompanied by reversible changes. Our results suggest that the natural metabolite glycine has a prophylactic and therapeutic effect on microcirculatory disturbances, which are induced by inflammatory-and-allergic mediator histamine.

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confidence: 64%

Effect of Glycine on the Microcirculation in Rat Mesenteric Vessels

Podoprigora

Nartsissov

2009

Bull Exp Biol Med

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“…On the contrary, short-time changes of CBF is associated with a physiological constriction/dilatation and they are the part of a normal reaction to neuronal stimulation [34]. The reply to a chemical stimulation of blood vessels is in a minute range [35], and these changes lead to an increase glucose concentration in a brain tissue [36,37]. Thus, the changes of a flux dysconnectivity considered in the present study can explain a physiological dynamic of a glucose concentration fluctuation in brain tissue under different levels of the CBF velocity magnitude.…”

Section: Defect and Diffusion Forum Vol 413mentioning

confidence: 99%

The Effect of Flux Dysconnectivity Functions on Concentration Gradients Changes in a Multicomponent Model of Convectional Reaction-Diffusion by the Example of a Neurovascular Unit

Nartsissov

2021

DDF

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A convectional diffusion of nutrients around the blood vessels in brain occurs in well-structured neurovascular units (NVU) including neurons, glia and micro vessels. A common feature of the process is a combination of a relatively high-speed delivery solution stream inside the blood vessel and a low-speed convectional flow in parenchyma. The specific trait of NVU is the existence of a tight cover layer around the vessels which is formed by shoots (end-feet) of astrocytes. This layer forms so called blood-brain barrier (BBB). Under different pathological states the permeability of BBB is changed. The concentration gradient of a chemical compound in NVU has been modelled using a combination of mathematical description of a cerebral blood flow (CBF) and further 3D diffusion away from the blood vessels borders. The governing equation for the blood flow is the non-steady-state Navier–Stokes equation for an incompressible non-Newtonian fluid flow without buoyancy effects. BBB is modeled by the flux dysconnectivity functions. The velocity of fluid flow in the paravascular space was estimated using Darcy's law. Finally, the diffusion of the nutrient is considered as a convectional reaction-diffusion in a porous media. By the example of glucose, it was shown that increased permeability of BBB yields an increased level of the nutrient even under essential (on 70%) decrease of CBF. Contrarily, a low BBB permeability breeds a decreased concentration level under increased (on 50%) CBF. Such a phenomenon is explained by a smooth enlarge of the direct diffusion area for a blood-to-brain border glucose transport having three-level organization.

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