FDG PETCT for assessing marrow involvement at staging pediatric nonhematological round cell malignancies

Shah, Sneha; Purandare, Nilendu; Kembhavi, Seema; Puranik, Ameya; Agrawal, Archi; Bedmutha, Akshay; Qureshi, Sajid; Chinnaswamy, Girish; Vora, Tushar; Prasad, Maya; Parambil, Badira Cheriyalinkal; Rangarajan, Venkatesh

doi:10.1097/mnm.0000000000001491

Cited by 5 publications

(2 citation statements)

References 13 publications

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“…Many pediatric malignancies usually have bone–BMI, such as lymphoma and neuroblastoma ( 17 , 18 ). In neuroblastoma, accurate staging is essential for prognosis and choosing appropriate treatment options ( 19 ).…”

Section: Discussionmentioning

confidence: 99%

Comparing the diagnostic value of 18F-FDG PET/CT scan and bone marrow biopsy in newly diagnosed pediatric neuroblastoma and ganglioneuroblastoma

Ren

Zhou

et al. 2022

Front. Oncol.

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ObjectiveThis study aims to compare the diagnostic value of 18F-fluorodeoxyglucose (18-FDG) positron emission tomography (PET)/computed tomography (CT) (18F-FDG PET/CT) scan and bone marrow biopsy (BMB) for evaluating bone marrow infiltration (BMI) in newly diagnosed pediatric neuroblastoma (NB) and ganglioneuroblastoma (GNB).MethodsWe retrospectively reviewed 51 patients with newly diagnosed NB and GNB between June 1, 2019 and May 31, 2022. Each patient had undergone 18F-FDG PET/CT and BMB within 1 week and received no treatment. Clinical data were collected and statistically analyzed, including age, sex, pathologic type, and laboratory parameters. 18F-FDG PET/CT and BMB revealed the result of bone lesions.ResultsA concordance analysis showed that, in this study population, 18F-FDG PET/CT and BMB were in moderate agreement (Cohen’s Kappa = 0.444; p = 0.001), with an absolute agreement consistency of 72.5% (37 of 51). The analysis of the receiver operating characteristic (ROC) curve determined that the areas under the ROC curve (AUCs) of SUVBM and SUV/HE-SUVmax were 0.971 (95% CI: 0.911–1.000; p < 0.001) and 0.917 (95% CI: 0.715–1.000; p < 0.001) to predict bone–bone marrow involvement (BMI), respectively.Conclusion18F-FDG PET/CT detects BMI with good diagnostic accuracy and can reduce unnecessary invasive inspections in newly diagnosed pediatric NB and GNB, especially patterns C and D. The analysis of the semi-quantitative uptake of 18F-FDG, including SUVBM and SUVBM/HE-SUVmax, enables an effective differentiation between patterns A and B.

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Section: Discussionmentioning

confidence: 99%

Comparing the diagnostic value of 18F-FDG PET/CT scan and bone marrow biopsy in newly diagnosed pediatric neuroblastoma and ganglioneuroblastoma

Ren

Zhou

et al. 2022

Front. Oncol.

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“…The authors estimated overall sensitivity, specificity, accuracy, PPV and NPV of PET/CT for detecting bone marrow involvement as 100 %, 86.1 %, 89.4 %, 68.9 % and 100 %, respectively. In both subgroups, the authors suggested that in patients PET/CT can negate the need for BMB [19].…”

Section: Overallmentioning

confidence: 99%

The Role of FDG- PET/CT in Detecting Bone Marrow Involvement in Childhood Solid Tumors

Arslantaş,

Ayçiçek,

Esen Akkas

et al. 2024

Nuklearmedizin

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Purpose To compare the results of 18F-Fluorodeoxy positron emission tomography/computed tomography (18 F-FDG-PET/CT) and bone marrow biopsy (BMB) procedures in the initial evaluation of bone marrow involvement (BMI) in pediatric solid tumors. Methods We conducted a retrospective analysis of newly diagnosed pediatric cases with lymphoma, neuroblastoma, Ewing sarcoma, rhabdomyosarcoma. Each case underwent both PET-CT imaging and BMB. Presence of tumor infiltration in BMB specimens and/or positive FDG-PET/CT findings indicate as BMI were regarded as true positive results. Results Sixty-four patients were included in the study. BMI was detected in 23/64 (36%) patients, FDG-PET/CT imaging and BMB results were concordant in 54/64 patients. In 9/64 patients the finding was FDG-PET/CT (+), BMB (-) indicating a false negative BMB result. In only 1/64 patients FDG- PET/CT (-), BMB (+), indicating a false negative FDG-PET/CT result. In the whole patient group, the sensitivity, specificity, positive predictive value and negative predictive value of PET/CT and BMB in detecting bone marrow involvement were 95.6%, 100%, 100% and 97.6% and 60.8 %, 100%, 100% and 82%, respectively. Conclusion PET/CT has a high sensitivity and specificity for the assessing marrow involvement in pediatric solid tumors. We believe that PET/CT imaging should be performed as the first step in diagnostic staging, and BMB may not be necessary in every patient, only in patients with suspicious PET/CT results for bone marrow involvement. Additionally, for a more precise determination of bone marrow involvement, it is reasonable to perform BMB from FDG-retaining areas, using PET/CT as a guide tool.

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Predictive value of 18 F-FDG PET/CT versus bone marrow biopsy and aspiration in pediatric neuroblastoma

Zhao,

Yang

2024

Clin Exp Metastasis

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FDG PETCT for assessing marrow involvement at staging pediatric nonhematological round cell malignancies

Cited by 5 publications

References 13 publications

Comparing the diagnostic value of 18F-FDG PET/CT scan and bone marrow biopsy in newly diagnosed pediatric neuroblastoma and ganglioneuroblastoma

Comparing the diagnostic value of 18F-FDG PET/CT scan and bone marrow biopsy in newly diagnosed pediatric neuroblastoma and ganglioneuroblastoma

The Role of FDG- PET/CT in Detecting Bone Marrow Involvement in Childhood Solid Tumors

Predictive value of 18 F-FDG PET/CT versus bone marrow biopsy and aspiration in pediatric neuroblastoma

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