FDG‐positive Warthin's tumors in cervical lymph nodes mimicking metastases in tongue cancer staging with PET/CT

Schwarz, Esther I.; Hürlimann, Sandra; Soyka, Jan; Bortoluzzi, Lucia; Strobel, Klaus

doi:10.1016/j.otohns.2008.09.019

Cited by 26 publications

(43 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Workup with PET/CT has been shown to indicate false positive results in head and neck cancer patients showing a CAL within neck lymph nodes mimicking a metastasis [14]. There was similarity with our case, where FDG-uptake was found in the larynx, and initially mistaken for a breast cancer metastasis.…”

Section: Discussionsupporting

confidence: 78%

Warthin's tumor of the larynx: A very rare case and systematic review of the literature

Nisa

Landis

Salmina

et al. 2015

Journal of Otolaryngology - Head & Neck Surgery

View full text Add to dashboard Cite

BackgroundWarthin’s tumor or cystadenolymphoma (CAL) is a benign salivary gland tumor occurring almost exclusively in the parotid gland. CALs of other locations are rare.Case presentationWe report a laryngeal CAL detected in a positron emission tomography/computed tomography (PET/CT) performed for breast cancer follow-up. The tumor was successfully treated by transoral surgery.DiscussionOnly 14 cases of laryngeal CAL are reported worldwide. These cases confirmed our experience of an uncomplicated and mostly successful transoral resection.ConclusionCALs of the larynx are very rare. They are characterized by hypermetabolism in PET/CT. The increasing use of PET/CT investigations in cancer patients could give rise to more incidental findings of CALs at unusual locations such as the larynx.

show abstract

Section: Discussionsupporting

confidence: 78%

Warthin's tumor of the larynx: A very rare case and systematic review of the literature

Nisa

Landis

Salmina

et al. 2015

Journal of Otolaryngology - Head & Neck Surgery

View full text Add to dashboard Cite

show abstract

“…PET has been reported to be positive in salivary gland tumors [12], particularly malignancies and Warthin's tumors [13,14]. There are case reports in the literature demonstrating this finding in patients with tongue cancer [15] and lung cancer [16]. However, the Otolaryngology-Head and Neck literature lacks sufficient attention to this problem.…”

Section: Discussionmentioning

confidence: 99%

Positron emission tomography in Warthin’s tumor mimicking malignancy impacts the evaluation of head and neck patients

Rassekh¹,

Cost²,

Hogg³

et al. 2015

American Journal of Otolaryngology

View full text Add to dashboard Cite

“…In our study, 5 patients were found to have incidental benign head and neck neoplasms, with a substantial proportion from major salivary gland tumors. Warthin tumor is one known head and neck tumor that has variable FDG uptakes, one of the pitfalls in the interpretation of head and neck PET/ CT. [14][15][16] These incidental neoplasms can mimic metastases and have an impact on the management of patients with HNSCC. Care should be taken when interpreting posttreatment head and neck PET/CT, with careful evaluation of the contrast-enhanced CT portion.…”

Section: Discussionmentioning

confidence: 99%

Positive Predictive Value of Neck Imaging Reporting and Data System Categories 3 and 4 Posttreatment FDG-PET/CT in Head and Neck Squamous Cell Carcinoma

Wangaryattawanich

Branstetter

et al. 2020

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

BACKGROUND AND PURPOSE: The Neck Imaging Reporting and Data System is a standardized reporting system intended to risk stratify patients treated for head and neck squamous cell carcinoma. The purpose of this study is to investigate the positive predictive value of the Neck Imaging Reporting and Data System categories 3 and 4 on posttreatment PET/CT in patients treated definitively for head and neck squamous cell carcinoma. MATERIALS AND METHODS:We retrospectively identified patients treated definitively for head and neck squamous cell carcinoma between 2006 and 2018. Patients whose posttreatment PET/CT scans were interpreted as Neck Imaging Reporting and Data System 3 (suspicious) or 4 (definitive recurrence) at the primary site, regional nodes, or at distant sites were included. The reference standard was histopathology or unequivocal imaging or clinical evidence of treatment failure. The positive predictive values of Neck Imaging Reporting and Data System 3 and 4 posttreatment PET/CT were calculated.RESULTS: Seventy-two of 128 patients with posttreatment PET/CT interpreted as Neck Imaging Reporting and Data System 3 at the primary site, regional nodes, or distant sites were proved to have treatment failure at the suspicious sites, yielding an overall positive predictive value of 56% (95% CI, 48%-65%). The positive predictive values of Neck Imaging Reporting and Data System 3 by subsite were as follows: primary site, 56% (44/79); regional nodes, 65% (34/52); and distant sites, 79% (42/53). All 69 patients with posttreatment PET/CT interpreted as Neck Imaging Reporting and Data System 4 had true treatment failure, yielding a positive predictive value of 100% (95% CI, 96%-100%): primary site, 100% (28/28); regional nodes, 100% (32/32); and distant sites, 100% (29/29). CONCLUSIONS:The positive predictive value of Neck Imaging Reporting and Data System 3 on posttreatment PET/CT is relatively low. Thus, Neck Imaging Reporting and Data System 3 findings should be confirmed with tissue sampling before instituting new salvage treatment regimens to avoid unnecessary overtreatment and its associated toxicities. Neck Imaging Reporting and Data System 4 reliably indicates recurrent disease. ABBREVIATIONS: AJCC ¼ American Joint Committee on Cancer; D ¼ distant sites; HNSCC ¼ head and neck squamous cell carcinoma; HPV ¼ human papillomavirus; N ¼ regional nodes; NI-RADS ¼ Neck Imaging Reporting and Data System; P ¼ primary site; PPV ¼ positive predictive value

show abstract

FDG‐positive Warthin's tumors in cervical lymph nodes mimicking metastases in tongue cancer staging with PET/CT

Cited by 26 publications

References 3 publications

Warthin's tumor of the larynx: A very rare case and systematic review of the literature

Warthin's tumor of the larynx: A very rare case and systematic review of the literature

Positron emission tomography in Warthin’s tumor mimicking malignancy impacts the evaluation of head and neck patients

Positive Predictive Value of Neck Imaging Reporting and Data System Categories 3 and 4 Posttreatment FDG-PET/CT in Head and Neck Squamous Cell Carcinoma

Contact Info

Product

Resources

About