FDP/fibrinogen ratio reflects the requirement of packed red blood cell transfusion in patients with blunt trauma

Hagiwara, Shinji; Aoki, Makoto; Murata, Masato; Kaneko, Minoru; Ichikawa, Yumi; Nakajima, Jun; Isshiki, Yuta; Sawada, Yusuke; Tamura, Jun’ichi; Oshima, Kiyohiro

doi:10.1016/j.ajem.2017.03.009

Cited by 2 publications

(4 citation statements)

References 22 publications

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“…In addition, FDP and D-dimer levels reflect the prognosis of critically ill patients [ 14 ] including those with novel coronavirus pneumonia [ 15 ]. We have also focused on the relationship between coagulo-fibrinolytic parameters such as FDP and D-dimer levels and severely ill patients including those with OHCA and trauma, and have published our results up to the present time [ 16 , 17 , 18 , 19 , 20 ]. However, it takes time to obtain the results of these parameters, although they are needed quickly in emergency clinical situations.…”

Section: Discussionmentioning

confidence: 99%

Sonoclot’s usefulness in prediction of cardiopulmonary arrest prognosis: A proof of concept study

et al. 2022

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The aim of the present study was to evaluate the usefulness of measuring whole blood coagulation with Sonoclot to predict return of spontaneous circulation (ROSC) in patients with out-of-hospital cardiopulmonary arrest (OHCA). This was a prospective, observational clinical study on patients with OHCA who were transferred to our emergency department between August 2016 and July 2018. Patients were divided into two groups: patients with return of spontaneous circulation (ROSC[+] group) and those without (ROSC[−] group). We compared the activated clotting time (ACT), clot rate (CR), and platelet function (PF) as measured with Sonoclot, and the fibrinogen degradation products (FDP) level and D-dimer level between the two groups. We analyzed 87 patients: 37 in the ROSC(+) and 50 in the ROSC(−) groups. Regarding ACT, CR, PF, FDP, and D-dimer, we used receiver operating characteristic (ROC) curves to examine how well each factor predicts ROSC. The area under the ROC curve (AUC) of CR was higher than that of the FDP and D-dimer levels. Among patients with cardiogenic cardiac arrest, the AUC of CR was higher than the AUCs of other coagulation factors. In conclusion, viscoelastic blood coagulation measurements using Sonoclot may be useful for predicting ROSC in OHCA patients.

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Section: Discussionmentioning

confidence: 99%

Sonoclot’s usefulness in prediction of cardiopulmonary arrest prognosis: A proof of concept study

et al. 2022

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“…We combined the high FDP and D-dimer, and the low fibrinogen, to the ratio of FDP to fibrinogen and the ratio of D-dimer to fibrinogen, this was a novel finding. This ratio was subsequently developed to the next stage [43,44].…”

Section: The Prediction Of Extravasation In Pelvic Fracture Using Coagulation Biomarkersmentioning

confidence: 99%

“…We applied coagulation biomarkers to the prediction of the need for packed red blood cell transfusions [43]. For a long time, many investigators have discussed how to predict massive transfusion requirements in blunt trauma patients [45][46][47][48][49][50][51].…”

Section: Prediction Of the Need For Packed Red Blood Cell Transfusions Using Coagulation Biomarkersmentioning

confidence: 99%

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Clinical Application of Coagulation Biomarkers

Aoki¹,

Hagiwara²,

Oshima³

2018

Biomarker - Indicator of Abnormal Physiological Process

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Coagulopathy is of intense interest in the fields of emergency medicine, with many recent studies of coagulation biomarkers for clinical use. The occurrence of disseminated intravascular coagulation (DIC) also resulted in the activation of studies about the coagulopathy. At present DIC has been admitted in many clinical conditions and many coagulation biomarkers have been studied. Fibrin degradation product (FDP) and D-dimer are one type of coagulation biomarker. A characteristic of FDP and D-dimer is the rapid and dynamic elevation of their levels when fibrinolysis occurs in several acute diseases. In this chapter, we present the clinical application of FDP and D-dimer. In trauma, FDP and -dimer have been used for the evaluation of trauma severity, to predict the likelihood of hemorrhage and to evaluate the need for the transfusion of packed red blood cells. In cardiac pulmonary arrest (CPA), FDP and D-dimer have been useful for predicting the return of spontaneous circulation. Thus, the measurement of coagulation biomarkers is useful in the diagnosis and/or treatment of trauma and CPA.

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FDP/fibrinogen ratio reflects the requirement of packed red blood cell transfusion in patients with blunt trauma

Cited by 2 publications

References 22 publications

Sonoclot’s usefulness in prediction of cardiopulmonary arrest prognosis: A proof of concept study

Sonoclot’s usefulness in prediction of cardiopulmonary arrest prognosis: A proof of concept study

Clinical Application of Coagulation Biomarkers

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