FDTD-based Transcranial Magnetic Stimulation model applied to specific neurodegenerative disorders

Fanjul-Vélez, F.; Salas-García, I.; Ortega-Quijano, Noé; Arce-Diego, J. L.

doi:10.1016/j.cmpb.2014.10.008

Cited by 12 publications

(8 citation statements)

References 21 publications

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“…The so-called A - V formulation of the magnetic field first solves the magnetic vector potential ( A ), then in a second step, derives the electric scalar potential ( V ). For the computational solution of these partial differential equations, researchers in the field use several different approaches, including finite difference methods (Fanjul-Vélez, Salas-García, Ortega-Quijano, & Arce-Diego, 2015; Toschi, Welt, Guerrisi, & Keck, 2008, 2009), finite volume methods (Goetz, Afinowi, et al, 2013; He & Liu, 2016), boundary element methods (Im & Lee, 2006; Nummenmaa et al, 2013; Salinas, Lancaster, & Fox, 2009), and impedance methods (De Geeter, Crevecoeur, & Dupre, 2011; De Geeter, Crevecoeur, Dupré, Van Hecke, & Leemans, 2012; De Geeter, Crevecoeur, Leemans, & Dupré, 2015; Nadeem, Thorlin, Gandhi, & Persson, 2003), while finite element methods (FEM) dominate (Bijsterbosch, Barker, Lee, & Woodruff, 2012; Chen & Mogul, 2009; Deng, et al, 2013; Janssen et al, 2013; Laakso & Hirata, 2012; Laakso, et al, 2014; W. H. Lee, Lisanby, Laine, & Peterchev, 2014; Miranda, et al, 2003; Opitz, et al, 2011; Masaki Sekino & Ueno, 2002; Thielscher, et al, 2011; Windhoff, Opitz, & Thielscher, 2013).…”

Section: Models Of the Induced Electric Field Distributionmentioning

confidence: 99%

The development and modelling of devices and paradigms for transcranial magnetic stimulation

Goetz

Deng

2017

International Review of Psychiatry

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Magnetic stimulation is a noninvasive neurostimulation technique that can evoke action potentials and modulate neural circuits through induced electric fields. Biophysical models of magnetic stimulation have become a major driver for technological developments and the understanding of the mechanisms of magnetic neurostimulation and neuromodulation. Major technological developments involve stimulation coils with different spatial characteristics and pulse sources to control the pulse waveform. While early technological developments were the result of manual design and invention processes, there is a trend in both stimulation coil and pulse source design to mathematically optimize parameters with the help of computational models. To date, macroscopically highly realistic spatial models of the brain as well as peripheral targets, and user-friendly software packages enable researchers and practitioners to simulate the treatment-specific and induced electric field distribution in the brains of individual subjects and patients. Neuron models further introduce the microscopic level of neural activation to understand the influence of activation dynamics in response to different pulse shapes. A number of models that were designed for online calibration to extract otherwise covert information and biomarkers from the neural system recently form a third branch of modeling.

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Section: Models Of the Induced Electric Field Distributionmentioning

confidence: 99%

The development and modelling of devices and paradigms for transcranial magnetic stimulation

Goetz

Deng

2017

International Review of Psychiatry

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“…However, the definite cure has not been discovered yet. Noninvasive techniques, like transcranial magnetic stimulation (TMS) or transcranial direct current stimulation (tDCS), have been proven to be secure and efficient [2].…”

Section: Introductionmentioning

confidence: 99%

“…Outer deep brain regions can be stimulated noninvasively by optical radiation. The stimulation of deeper regions requires a surgical intervention [2]. Neural activity can be varied by optical radiation by employing ONS over specific brain regions.…”

Section: Introductionmentioning

confidence: 99%

Analysis of optical neural stimulation effects on neural networks affected by neurodegenerative diseases

et al. 2016

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The number of people in risk of developing a neurodegenerative disease increases as the life expectancy grows due to medical advances. Multiple techniques have been developed to improve patient's condition, from pharmacological to invasive electrodes approaches, but no definite cure has yet been discovered.In this work Optical Neural Stimulation (ONS) has been studied. ONS stimulates noninvasively the outer regions of the brain, mainly the neocortex. The relationship between the stimulation parameters and the therapeutic response is not totally clear. In order to find optimal ONS parameters to treat a particular neurodegenerative disease, mathematical modeling is necessary. Neural networks models have been employed to study the neural spiking activity change induced by ONS. Healthy and pathological neocortical networks have been considered to study the required stimulation to restore the normal activity. The network consisted of a group of interconnected neurons, which were assigned 2D spatial coordinates. The optical stimulation spatial profile was assumed to be Gaussian. The stimulation effects were modeled as synaptic current increases in the affected neurons, proportional to the stimulation fluence. Pathological networks were defined as the healthy ones with some neurons being inactivated, which presented no synaptic conductance. Neurons' electrical activity was also studied in the frequency domain, focusing specially on the changes of the spectral bands corresponding to brain waves. The complete model could be used to determine the optimal ONS parameters in order to achieve the specific neural spiking patterns or the required local neural activity increase to treat particular neurodegenerative pathologies.

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“…Nowadays multiple techniques of nervous system stimulation have developed and studied, but the definite cure still has not been discovered. There are noninvasive techniques, like transcranial magnetic stimulation (TMS) or transcranial direct current stimulation (tDCS), that have been proven to be secure and efficient [2].…”

Section: Introductionmentioning

confidence: 99%

“…Optical radiation can stimulate outer deep brain regions noninvasively, but the stimulation of deeper regions requires a surgical intervention [2]. ONS stimulates brain regions via optical radiation and alters neural activity.…”

Section: Introductionmentioning

confidence: 99%

Optical Neural Stimulation Modeling on Degenerative Neocortical Neural Networks

Zverev¹,

Fanjul-Vélez²,

Salas-García³

et al. 2015

Advanced Microscopy Techniques IV; And Neurophotonics II

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Neurodegenerative diseases usually appear at advanced age. Medical advances make people live longer and as a consequence, the number of neurodegenerative diseases continuously grows. There is still no cure for these diseases, but several brain stimulation techniques have been proposed to improve patients' condition. One of them is Optical Neural Stimulation (ONS), which is based on the application of optical radiation over specific brain regions. The outer cerebral zones can be noninvasively stimulated, without the common drawbacks associated to surgical procedures. This work focuses on the analysis of ONS effects in stimulated neurons to determine their influence in neuronal activity. For this purpose a neural network model has been employed. The results show the neural network behavior when the stimulation is provided by means of different optical radiation sources and constitute a first approach to adjust the optical light source parameters to stimulate specific neocortical areas.

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FDTD-based Transcranial Magnetic Stimulation model applied to specific neurodegenerative disorders

Cited by 12 publications

References 21 publications

The development and modelling of devices and paradigms for transcranial magnetic stimulation

The development and modelling of devices and paradigms for transcranial magnetic stimulation

Analysis of optical neural stimulation effects on neural networks affected by neurodegenerative diseases

Optical Neural Stimulation Modeling on Degenerative Neocortical Neural Networks

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