Fe- and Zn-induced inhibition of Cd uptake in human lung cell lines: Speciation studies with H441 and A549 cells

Mantha, Marc; Idrissi, Loubna El; Leclerc-Beaulieu, Tatiana; Jumarie, Catherine

doi:10.1016/j.tiv.2011.08.006

Cited by 8 publications

(3 citation statements)

References 51 publications

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“…However, the A549 line appears to be twice as sensitive to Cd as H441 cells, and Cd cell accumulation studies indicate that the difference of this sensitivity between the lines is not related to a greater accumulation of Cd but rather attributable to other cellular protection mechanisms such as the presence and/or induction of MTs, GSH, or HSP70. It would therefore be relevant to compare the antioxidant capacity as well as the induction levels of these stress proteins in cells A549 and H441 [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

The Influence of Heavy Metals and Trace Elements on Comatose Patients with Severe Traumatic Brain Injury in the First Week of Admission

Belatar¹,

Elabidi²,

Barkiyou³

et al. 2018

Journal of Toxicology

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Purpose The aim of this study is to investigate the possible role of heavy metals (lead and cadmium) and imbalance of trace elements (chromium, iron, zinc, copper, and manganese) in death among patients with severe traumatic brain injury. Material and Methods A case-control study was conducted with 64 comatose patients with severe TBI, in the Department of Anesthesiology and Reanimation, Ibn Sina University Hospital and Hospital of Specialties in Rabat, Morocco; 22 healthy volunteers were recruited in Blood Transfusion Center of Rabat. Blood samples were collected from TBI patients, in the first week (3h after admission and each 48h during one week) and from healthy volunteers one time. Concentration of heavy metals and trace elements in serum was determined by electrochemical atomic absorption spectrometry. Statistical analysis was performed using Statistical software (SPSS) and the cases and controls were compared using the Mann–Whitney U test and Student's t-test for cadmium according to gender and final evolution. A P-value <0.05 was considered to be statistically significant. Results Our data showed that the difference of heavy metals concentration (lead and cadmium) between patients and healthy subjects was not statistically significant. However, the difference of some trace elements concentration (iron, copper, chromium, and selenium) between patients and healthy subjects was statistically significant. According to the final evolution, the concentration of manganese was higher in dead patients and statistically significant (p = 0.04) for heavy metals; the concentration of lead was not statistically significant while the concentration in cadmium was statistically significant (p = 0.004). By sex, lead and cadmium were statistically significant, respectively p = 0.02, p = 0.001, and cadmium was higher in women, while lead was higher in men. Conclusion Among all studied heavy metals (lead and cadmium) and trace elements (iron, zinc, copper, selenium, chromium, and manganese), manganese and cadmium may play a role in the death of patients from severe traumatic brain injury.

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Section: Discussionmentioning

confidence: 99%

The Influence of Heavy Metals and Trace Elements on Comatose Patients with Severe Traumatic Brain Injury in the First Week of Admission

Belatar¹,

Elabidi²,

Barkiyou³

et al. 2018

Journal of Toxicology

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“…Additionally, a marked decrease in cell viability and protein content was found for this mixture. Fe and Zn can also interfer in other ions uptake processes 56, 57. It was suggested that the synergism of the mixture Cu + Zn was evident as the redox‐active metal Cu could enhance the Zn absorption in a living system 58, 59.…”

Section: Discussionmentioning

confidence: 99%

“…Fe and Zn can also interfer in other ions uptake processes. 56,57 It was suggested that the synergism of the mixture Cu þ Zn was evident as the redox-active metal Cu could enhance the Zn absorption in a living system. 58,59 Furthermore, this combination of Cu þ Zn might also play a main role in the mixtures with other ions.…”

Section: Effect Of Individual Ions and Synergistic Cytotoxic Effects mentioning

confidence: 99%

Synergistic cytotoxic effects of ions released by zinc–aluminum bronze and the metallic salts on osteoblastic cells

Grillo

Morales

Mirífico

et al. 2013

J Biomedical Materials Res

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The use of copper-based alloys for fixed dental crowns and bridges is increasingly widespread in several countries. The aim of this work is to study the dissolution of a zinc-aluminum-bronze and the cytotoxic effects of the ions released on UMR-106 osteoblastic cell line. Two sources of ions were used: (1) ions released by the metal alloy immersed in the cell culture and (2) salts of the metal ions. Conventional electrochemical techniques, atomic absorption spectroscopy [to obtain the average concentration of ions (AC) in solution], and energy dispersive X-ray (EDX) spectroscopy analysis were used to study the corrosion process. Corrosion tests revealed a strong influence of the composition of the electrolyte medium and the immersion time on the electrochemical response. The cytotoxicity was evaluated with (a) individual ions, (b) combinations of two ions, and (c) the mixture of all the ions released by a metal disc of the alloy. Importantly, synergistic cytotoxic effects were found when Al-Zn ion combinations were used at concentration levels lower than the cytotoxic threshold values of the individual ions. Cytotoxic effects in cells in the vicinity of the metal disc were also found. These results were interpreted considering synergistic effects and a diffusion controlled mechanism that yields to concentration levels, in the metal surroundings, several times higher than the measured AC value.

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Toxicology of Cadmium and Its Damage to Mammalian Organs

Thévenod

Lee

2012

Metal Ions in Life Sciences

162

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The detrimental health effects of cadmium (Cd) were first described in the mid 19th century. As part of industrial developments, increasing usage of Cd has led to widespread contamination of the environment that threatens human health, particularly today. Rather than acute, lethal exposures, the real challenge in the 21st century in a global setting seems to be chronic low Cd exposure (CLCE), mainly from dietary sources. Ubiquity of Cd makes it a serious environmental health problem that needs to be thoroughly assessed because it already affects or will affect large proportions of the world's population. CLCE is a health problem that affects increasingly organ toxicity, especially nephrotoxicity, without a known threshold, implying that there is currently no safe limit for CLCE. In this chapter, we summarize current knowledge on the sources of Cd in the environment, describe the entry pathways for Cd into mammalian organisms, sum up the major organs targeted by acute or chronic Cd exposure and review the impact of Cd on organ function and human health. We also aim to put early pioneering studies on Cd poisoning into perspective in the context of recent ground-breaking prospective long-term population studies, which link CLCE to leading causes of diseases in modern societies - cancer, diabetes, and cardiovascular diseases, and of state-of-the-art studies detailing cellular and molecular mechanisms of acute and chronic Cd toxicity.

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Fe- and Zn-induced inhibition of Cd uptake in human lung cell lines: Speciation studies with H441 and A549 cells

Cited by 8 publications

References 51 publications

The Influence of Heavy Metals and Trace Elements on Comatose Patients with Severe Traumatic Brain Injury in the First Week of Admission

The Influence of Heavy Metals and Trace Elements on Comatose Patients with Severe Traumatic Brain Injury in the First Week of Admission

Synergistic cytotoxic effects of ions released by zinc–aluminum bronze and the metallic salts on osteoblastic cells

Toxicology of Cadmium and Its Damage to Mammalian Organs

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