Fe–Decorated Nitrogen–Doped Carbon Nanospheres as an Electrochemical Sensing Platform for the Detection of Acetaminophen

Zhao, Xiangchuan; Zhang, Liping; Chu, Zhaoyun; Wang, Qing; Cao, Yue; Cao, Jun; Li, Jiao; Lei, Wu; Zhang, Boming; Si, Weimeng

doi:10.3390/molecules28073006

Cited by 11 publications

(3 citation statements)

References 53 publications

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“…The linearity of the dependency may indicate that the etoposide oxidation catalyzed by NPG was a diffusion-controlled process [31]. We hypothesized that NPG catalyzed the oxidation of the phenolic hydroxyl group on etoposide to produce etoposide quinone (Figure 1) in the detection of many phenolic compounds using electrochemical sensors based on the oxidation of the phenolic hydroxyl groups [32,33]. The performance of the NPG/GCE was tested using the DPV method to establish a mathematical relationship between peak current and etoposide concentration.…”

Section: Electrochemical Detection Of Etoposide By Npg/gcementioning

confidence: 99%

Rapid Detection of the Anti-Tumor Drug Etoposide in Biological Samples by Using a Nanoporous-Gold-Based Electrochemical Sensor

Yu,

Hu,

Wang

et al. 2024

Molecules

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Monitoring etoposide is important due to its wide usage in anti-tumor therapy; however, the commonly used HPLC method is expensive and often requires complicated extraction and detection procedures. Electrochemical analysis has great application prospects because of its rapid response and high specificity, sensitivity, and efficiency with low cost and high convenience. In this study, we constructed a nanoporous gold (NPG)-modified GCE for the detection of etoposide. The electrochemical oxidation of etoposide by NPG caused a sensitive current peak at +0.27 V with good reproductivity in 50 mM of phosphate buffer (pH 7.4). The relationship between etoposide concentration and peak current was linear in the range between 0.1 and 20 μM and between 20 and 150 μM, with a detection sensitivity of 681.8 μA mM−1 cm−2 and 197.2 μA mM−1 cm−2, respectively, and a limit of detection (LOD) reaching 20 nM. The electrode had a good anti-interference ability to several common anions and cations. Spiked recovery tests in serum, urine, and fermentation broth verified the excellent performance of the sensor in terms of sensitivity, reproducibility, and specificity. This may provide a promising tool for the detection of etoposide in biological samples.

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Section: Electrochemical Detection Of Etoposide By Npg/gcementioning

confidence: 99%

Rapid Detection of the Anti-Tumor Drug Etoposide in Biological Samples by Using a Nanoporous-Gold-Based Electrochemical Sensor

Yu,

Hu,

Wang

et al. 2024

Molecules

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“…Among the electrochemical methods is cyclic voltammetry (CV), which offers great versatility to study electroactive substances. Currently, a wide variety of nanomaterials have been designed for the modification of electroactive surfaces, and to optimize the determination of electroactive compounds of interest by increasing their surface and adsorption sites, improving the selective interactions between the electrode and the substance, and achieving a greater sensitivity and performance [12][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

A Facile Glycerol-Assisted Synthesis of Low-Cu2+-Doped CoFe2O4 for Electrochemical Sensing of Acetaminophen

Alfonso-González,

Granja-Banguera,

Morales-Morales

et al. 2023

Biosensors

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This work devised a simple glycerol-assisted synthesis of a low-Cu2+-doped CoFe2O4 and the electrochemical detection of acetaminophen (AC). During the synthesis, several polyalcohols were tested, indicating the efficiency of glycerin as a cosolvent, aiding in the creation of electrode-modifier nanomaterials. A duration of standing time (eight hours) before calcination produces a decrease in the secondary phase of hematite. The synthesized material was used as an electrode material in the detection of AC. In acidic conditions (pH 2.5), the limit of detection (LOD) was 99.4 nM, while the limit of quantification (LOQ) was found to be (331 nM). The relative standard deviation (RSD), 3.31%, was computed. The enhanced electrocatalytic activity of a low-Cu2+-doped CoFe2O4-modified electrode Cu0.13Co0.87Fe2O4/GCE corresponds extremely well with its resistance Rct, which was determined using the electrochemical impedance spectroscopy (EIS) technique and defined its electron transfer capacity. The possibility of a low-Cu2+-doped CoFe2O4 for the electrochemical sensing of AC in human urine samples was studied. The recovery rates ranging from 96.5 to 101.0% were obtained. These findings suggested that the Cu0.13Co0.87Fe2O4/GCE sensor has outstanding practicability and could be utilized to detect AC content in real complex biological samples.

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“…Acetaminophen (ACP, also known as paracetamol) is a widely used analgesic and antipyretic medication clinically used to treat symptoms such as fever, cold, and aches and pains. 1,2 Because of its aspirin-like effects, it's an excellent alternative for aspirin-sensitive people. 3 However, an overdose of ACP can damage the kidneys and liver, and it can potentially cause rapid liver failure and death.…”

mentioning

confidence: 99%

A Novel Electrochemical Sensing Based on Cerium Oxide/Nitrogen-Doped Reduced Graphene Oxide for Sensitive Detection of Acetaminophen

Qi,

Wang,

Yuan

et al. 2024

J. Electrochem. Soc.

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Acetaminophen (ACP), a common analgesic and antipyretic medication, can harm the liver when overdosed and its metabolites can contaminate the environment, so it is necessary to monitor the concentration precisely and reliably. In this work, we successfully synthesized cerium oxide/nitrogen-doped reduced graphene oxide (CeO2/N-rGO) composite nanomaterials using a one-step hydrothermal method. Using composite nanomaterials, we created an electrochemical sensing detection platform for ACP detection. The synthesized materials were characterized by scanning electron microscopy, transmission electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy, Raman spectroscopy, and X-ray photoelectron spectroscopy. The constructed electrochemical sensor exhibits good ACP detection ability under the synergistic effect of CeO2 and N-rGO. Under optimal experimental conditions, the sensor displayed a linear range for the detection of ACP of 1~200 μM and the lowest detection limit of 0.79 μM, exhibiting outstanding selectivity, stability, and repeatability. Furthermore, the sensor was effectively applied to detect ACP in tap water samples, which offers a wide range of possible applications in actual sample testing.

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Fe–Decorated Nitrogen–Doped Carbon Nanospheres as an Electrochemical Sensing Platform for the Detection of Acetaminophen

Cited by 11 publications

References 53 publications

Rapid Detection of the Anti-Tumor Drug Etoposide in Biological Samples by Using a Nanoporous-Gold-Based Electrochemical Sensor

Rapid Detection of the Anti-Tumor Drug Etoposide in Biological Samples by Using a Nanoporous-Gold-Based Electrochemical Sensor

A Facile Glycerol-Assisted Synthesis of Low-Cu2+-Doped CoFe2O4 for Electrochemical Sensing of Acetaminophen

A Novel Electrochemical Sensing Based on Cerium Oxide/Nitrogen-Doped Reduced Graphene Oxide for Sensitive Detection of Acetaminophen

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