Fe–FeO<sub><i>x</i></sub> nanoparticles encapsulated in N-doped carbon material: a facile catalyst for selective synthesis of quinazolines from alcohols in water

Wang, Fei; Zhu, Fayan; Ren, Enxiang; Zhang, Qiang; Lu, Guo‐ping; Lin, Yamei

doi:10.1039/d2cy01562e

Catal. Sci. Technol.

2022

DOI: 10.1039/d2cy01562e

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Fe–FeO_x nanoparticles encapsulated in N-doped carbon material: a facile catalyst for selective synthesis of quinazolines from alcohols in water

Fei Wang

Fayan Zhu

Enxiang Ren

et al.

Abstract: The development of efficient and green synthetic strategies for N-heterocycle synthesis has always been a research hotspot in organic synthesis. A facile one-pot iron-catalyzed synthesis of quinazolines from alcohols in...

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Syntheses of 2,4‐Substituted Quinazolines via One‐Pot Three‐Component Reactions Based on Manganese Dioxide/tert‐Butyl Hydrogen Peroxide Co‐Oxidation Using Alcohols

Wang,

Huang,

Chen

et al. 2024

Journal of Heterocyclic Chem

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Quinazolines and their derivatives occur in various natural products and pharmaceuticals, and thus, various methods of synthesizing quinazolines have been explored. They have traditionally been synthesized via two‐component reactions, but these strategies often suffer from the unavailability of the starting materials and limited substrate scopes. To overcome these problems, three‐component reactions using additional N sources were developed. Aldehydes were initially used in these reactions, but alcohols are greener and less toxic than aldehydes. However, the previously reported methods involving the use of alcohols require the utilization of transition metal catalysts, ultrahigh temperatures, and extended durations. Thus, an efficient, practical method of synthesizing quinazolines using alcohol is desirable. A facile one‐pot three‐component method of synthesizing quinazolines utilizing alcohols, 2‐aminobenzoketones, and ammonium acetate is reported for the first time, using active MnO2 and tert‐butyl hydrogen peroxide (TBHP) as synergistic oxidants. MnO2 and TBHP play dual roles: First, they oxidize the alcohol to the aldehyde and then facilitate the transformation of the intermediate into the product. During alcohol oxidation, the synergistic effect of MnO2 and TBHP is particularly evident. The aldehydes generated in situ via alcohol oxidation undergo immediate subsequent reactions, thereby minimizing their volatilization and side reactions, such as oxidation and polymerization.

show abstract

Syntheses of 2,4‐Substituted Quinazolines via One‐Pot Three‐Component Reactions Based on Manganese Dioxide/tert‐Butyl Hydrogen Peroxide Co‐Oxidation Using Alcohols

Wang,

Huang,

Chen

et al. 2024

Journal of Heterocyclic Chem

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Single cobalt atom catalysis for the construction of quinazolines and quinazolinones via the aerobic dehydrocyclization of ethanol

Zhang,

Xu,

Zhuang

et al. 2025

Green Chem.

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Fe–FeO_x nanoparticles encapsulated in N-doped carbon material: a facile catalyst for selective synthesis of quinazolines from alcohols in water

Abstract: The development of efficient and green synthetic strategies for N-heterocycle synthesis has always been a research hotspot in organic synthesis. A facile one-pot iron-catalyzed synthesis of quinazolines from alcohols in...

Cited by 2 publications

References 62 publications

Syntheses of 2,4‐Substituted Quinazolines via One‐Pot Three‐Component Reactions Based on Manganese Dioxide/tert‐Butyl Hydrogen Peroxide Co‐Oxidation Using Alcohols

Syntheses of 2,4‐Substituted Quinazolines via One‐Pot Three‐Component Reactions Based on Manganese Dioxide/tert‐Butyl Hydrogen Peroxide Co‐Oxidation Using Alcohols

Single cobalt atom catalysis for the construction of quinazolines and quinazolinones via the aerobic dehydrocyclization of ethanol

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Fe–FeOx nanoparticles encapsulated in N-doped carbon material: a facile catalyst for selective synthesis of quinazolines from alcohols in water

Abstract: The development of efficient and green synthetic strategies for N-heterocycle synthesis has always been a research hotspot in organic synthesis. A facile one-pot iron-catalyzed synthesis of quinazolines from alcohols in...

Cited by 2 publications

References 62 publications

Syntheses of 2,4‐Substituted Quinazolines via One‐Pot Three‐Component Reactions Based on Manganese Dioxide/tert‐Butyl Hydrogen Peroxide Co‐Oxidation Using Alcohols

Syntheses of 2,4‐Substituted Quinazolines via One‐Pot Three‐Component Reactions Based on Manganese Dioxide/tert‐Butyl Hydrogen Peroxide Co‐Oxidation Using Alcohols

Single cobalt atom catalysis for the construction of quinazolines and quinazolinones via the aerobic dehydrocyclization of ethanol

Contact Info

Product

Resources

About

Fe–FeO_x nanoparticles encapsulated in N-doped carbon material: a facile catalyst for selective synthesis of quinazolines from alcohols in water