Fe(II) Complexes Containing Bioactive Ligands: Synthesis, DNA Binding, and Cleavage Studies

Sreekanth, B.; Krishnamurthy, G.; Naik, H.S. Bhojya; Prabhakara, M.C.; Vishnuvardhan, T. K.

doi:10.1080/15533174.2010.522665

Cited by 8 publications

(2 citation statements)

References 49 publications

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“…Synthesis of Mixed Ligand. 2-Seleno-4-methylquinoline(L 1 ) was synthesised by the procedure reported [25,26] and mixed with 1,10-phenanthroline(L 2 ) in the ratio 1:2 in hot ethanolic solution, refluxed for 1 hour at −80 • C. The mixed ligand was dried and recrystallized using ethylactatate. (1) and (2).…”

Section: Synthesis Of Ligand ([1-{[2-{[2-hydroxynaphthalen-1-yl)methymentioning

confidence: 99%

Synthesis, DNA Binding, and Oxidative Cleavage Studies of Fe(II) and Co(III) Complexes Containing Bioactive Ligands

Sreekanth¹,

Krishnamurthy

Naik

et al. 2011

Nucleosides, Nucleotides and Nucleic Acids

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The two complexes containing bioactive ligands of the type and [Fe(L)] (PF(6))(2) (1) (where L = [1-{[2-{[2-hydroxynaphthalen-1-yl)methylidine]amino}phenyl)imino] methyl}naphthalene-2-ol]) and [Co(L(1)L(2))] (PF(6))(3) (2) (where L(1)L(2) = mixed ligand of 2-seleno-4-methylquinoline and 1,10-phenanthroline in the ratio 1:2, respectively) were synthesized and structurally characterized. The DNA binding property of the complexes with calf thymus DNA has been investigated using absorption spectra, viscosity measurements, and thermal denaturation experiments. Intrinsic binding constant K(b) has been estimated at room temperature. The absorption spectral studies indicate that the complexes intercalate between the base pairs of the CT-DNA tightly with intrinsic DNA binding constant of 2.8 × 10(5) M(-1) for (1) and 4.8 × 10(5) M(-1) for (2) in 5 mM Tris-HCl/50 mM NaCl buffer at pH 7.2, respectively. The oxidative cleavage activity of (1) and (2) were studied by using gel electrophoresis and the results show that complexes have potent nuclease activity.

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Section: Synthesis Of Ligand ([1-{[2-{[2-hydroxynaphthalen-1-yl)methymentioning

confidence: 99%

Synthesis, DNA Binding, and Oxidative Cleavage Studies of Fe(II) and Co(III) Complexes Containing Bioactive Ligands

Sreekanth¹,

Krishnamurthy

Naik

et al. 2011

Nucleosides, Nucleotides and Nucleic Acids

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“…The concentration of CT-DNA per nucleotide [C(p)] was measured using its known extinction coefficient at 260 nm (6600 M −1 cm −1 ) (32). The absorbance at 260 nm (A 260 ) and 280 nm (A 280 ) for CT-DNA were measured in order to check the purity level.…”

Section: Dna Binding Experimentsmentioning

confidence: 99%

Metal Complexes of New Tetraazamacrocyclic Constrained Oxadiazole Ring as Subunits: Synthesis, DNA Binding and Photonuclease Activity

Kumar

Naik

Girija

et al. 2012

Journal of Macromolecular Science, Part A

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A new tetraazamacrocyclic ligand, L (C 24 H 16 N 12 O 6 ) and its complexes of type, [MLCl 2 ] and [CuL]Cl 2 (Where M = Co(II), Fe(II); L = N,N -(benzene-1,3-diyldi-1,3,4-oxadiazole-5,2-diyl)bis{2-[(5-benzene-1,3-diyl-1,3,4-oxadiazol-2-yl)amino]acetamide}) were synthesized and characterized by elemental analysis including IR, 1 H NMR, 13 C NMR, mass and electronic spectral data. An octahedral geometry has been proposed for Fe(II) and Co(II) complexes except the Cu(II) complex which have a square planar environment. The binding property of the complexes with CT-DNA was studied by absorption spectra, viscosity measurement and thermal denaturation studies. The absorption spectral results indicate that the complexes binds with the base pairs of DNA with an intrinsic binding constant K b of Cu(II), Co(II) and Fe(II) complexes were found to be 4.5 × 10 4 M −1 , 5.7 × 10 4 M −1 and 2.6 × 10 4 M −1 , respectively in 5 mM Tris-HCl/50 mM NaCl buffer at pH 7.2. The photo induced cleavage studies revealed that the complexes show photonuclease property against pUC19 DNA under UV-visible irradiation.

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Synthesis, Characterization, DFT Studies and Biological Activity of Ru(III), La(III) and Ce(III) Triphenylphosphine Complexes Containing 2-Aminothiazole and 2-Aminotriazole

Naik

Krishnamurthy

et al. 2020

J Inorg Organomet Polym

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Fe(II) Complexes Containing Bioactive Ligands: Synthesis, DNA Binding, and Cleavage Studies

Cited by 8 publications

References 49 publications

Synthesis, DNA Binding, and Oxidative Cleavage Studies of Fe(II) and Co(III) Complexes Containing Bioactive Ligands

Synthesis, DNA Binding, and Oxidative Cleavage Studies of Fe(II) and Co(III) Complexes Containing Bioactive Ligands

Metal Complexes of New Tetraazamacrocyclic Constrained Oxadiazole Ring as Subunits: Synthesis, DNA Binding and Photonuclease Activity

Synthesis, Characterization, DFT Studies and Biological Activity of Ru(III), La(III) and Ce(III) Triphenylphosphine Complexes Containing 2-Aminothiazole and 2-Aminotriazole

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