Fe(III) doped carbon nanodots with intense green photoluminescence and dispersion medium dependent emission

Stan, Corneliu Sergiu; Coroabă, Adina; Ursu, Elena-Laura; Secula, Marius Sebastian; Simionescu, Bogdan C.

doi:10.1038/s41598-019-55264-x

Cited by 10 publications

(8 citation statements)

References 43 publications

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“…The peaks around 620 and 1378 cm –1 were ascribed to C–H related to aromatic ring bending. The peaks around 453 cm –1 were ascribed to the Fe–O related to aromatic ring bending and Fe–O-stretch (Figure F).…”

Section: Resultsmentioning

confidence: 99%

Functionalized Fe-Doped Carbon Dots Exhibiting Dual Glutathione Consumption to Amplify Ferroptosis for Enhanced Cancer Therapy

Zhou,

Yang,

Yin

et al. 2023

ACS Appl. Mater. Interfaces

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Nonapoptotic ferroptosis is a promising cancer treatment which offers a solution to the multidrug resistance of conventional apoptosis-induced programmed cancer cell death therapies. Reducing intracellular glutathione (GSH) is essential for inducing excess ROS and has been considered a crucial process to trigger ferroptosis. However, treatments reducing GSH alone have not produced satisfactory effects due to their restricted target. In this regard, FeCDs (Fe 3+ -modified L-histidine -sourced carbon dots) with dual GSH-consumption capabilities were constructed to engineer ferroptosis by self-amplifying intratumoral oxidative stress. Carbon dots have the ability to consume GSH, and the introduction of Fe 3+ can amplify the GSH-consuming ability of CDs, reacting with excess H 2 O 2 in the tumor microenvironment to generate highly oxidized • OH. This is a novel strategy through synergistic self-amplification therapy combining Fe 3+ and CDs with GSH-consuming activity. The acid-triggered degradation material (FeCDs@PAE−PEG) was prepared by encapsulating FeCDs in an oil-in-water manner. Compared with other ferroptosis-triggering nanoparticles, the established FeCDs@PAE−PEG is targeted and significantly enhances the consumption efficiency of GSH and accumulation of excess iron without the involvement of infrared light and ultrasound. This synergistic strategy exhibits excellent ferroptosis-inducing ability and antitumor efficacy both in vitro and in vivo and offers great potential for clinical translation of ferroptosis.

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Section: Resultsmentioning

confidence: 99%

Functionalized Fe-Doped Carbon Dots Exhibiting Dual Glutathione Consumption to Amplify Ferroptosis for Enhanced Cancer Therapy

Zhou,

Yang,

Yin

et al. 2023

ACS Appl. Mater. Interfaces

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“…The fine-grinding stage is essential for obtaining CDs with intense PL emission. In the next stage, the fine-grained ligno-cellulosic waste is thermally processed in a setup consisting of a quartz tube, a heating mantle, a temperature/flow controlled hot air source, and a cold-water container for the primary dispersion step [ 34 ].…”

Section: Methodsmentioning

confidence: 99%

Intense Blue Photo Emissive Carbon Dots Prepared through Pyrolytic Processing of Ligno-Cellulosic Wastes

et al. 2022

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In this work, Carbon Dots with intense blue photo-luminescent emission were prepared through a pyrolytic processing of forestry ligno-cellulosic waste. The preparation path is simple and straightforward, mainly consisting of drying and fine grinding of the ligno-cellulosic waste followed by thermal exposure and dispersion in water. The prepared Carbon Dots presented characteristic excitation wavelength dependent emission peaks ranging within 438–473 nm and a remarkable 28% quantum yield achieved at 350 nm excitation wavelength. Morpho-structural investigations of the prepared Carbon Dots were performed through EDX, FT-IR, Raman, DLS, XRD, and HR-SEM while absolute PLQY, steady state, and lifetime fluorescence were used to highlight their luminescence properties. Due to the wide availability of this type of ligno-cellulosic waste, an easy processing procedure achieved photo-luminescent properties, and the prepared Carbon Dots could be an interesting approach for various applications ranging from sensors, contrast agents for biology investigations, to photonic conversion mediums in various optoelectronic devices. Additionally, their biocompatibility and waste valorization in new materials might be equally good arguments in their favor, bringing a truly “green” approach.

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“…The preparation of the doped CDs-NHF was performed according to the procedure and the experimental setup mentioned in our previous work [ 38 ]. N-Hydroxyphthalimide (97%) (NHF) and anhydrous MnCl 2 were sourced from Merck Chemicals.…”

Section: Methodsmentioning

confidence: 99%

“…The precipitate is collected, washed twice with water, and further freeze dried. In the second stage, the prepared complex is thermally processed through pyrolysis in the same conditions and process parameters using the previously mentioned experimental setup [ 38 ]. The resulted aqueous dispersion of Mn-CDs-NHF was purified and dimensionally selected through centrifugation and further freeze dried to obtain a fine powder which was re-dispersed in a convenient solvent according to the testing requirements.…”

Section: Methodsmentioning

confidence: 99%

Manganese-Doped N-Hydroxyphthalimide-Derived Carbon Dots—Theranostics Applications in Experimental Breast Cancer Models

et al. 2021

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Background: Theranostics, a novel concept in medicine, is based on the use of an agent for simultaneous diagnosis and treatment. Nanomaterials provide promising novel approaches to theranostics. Carbon Dots have been shown to exhibit anti-tumoral properties in various cancer models. The aim of the present study is to develop gadolinium, Fe3+, and Mn2+-doped N-hydroxyphthalimide-derived Carbon Dots. The resulted doped Carbon Dots should preserve the anti-tumoral properties while gaining magnetic resonance imaging properties. Methods: Normal and cancer cell lines have been treated with doped Carbon Dots, and the cell viability has been measured. The doped Carbon Dots that exhibited the most prominent anti-tumoral effect accompanied by the lowest toxicity have been further in vivo tested. Magnetic resonance imaging evaluates both in vitro and in vivo the possibility of using doped Carbon Dots as a contrast agent. Results: According to the results obtained from both the in vitro and in vivo experimental models used in our study, Mn2+-doped Carbon Dots (Mn-CDs-NHF) exhibit anti-tumoral properties, do not significantly impair the cell viability of normal cells, and reduce lung metastasis and the volume of mammary primary tumors while allowing magnetic resonance imaging. Conclusions: Our findings prove that Mn-CDs-NHF can be used as theranostics agents in pre-clinical models.

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Fe(III) doped carbon nanodots with intense green photoluminescence and dispersion medium dependent emission

Cited by 10 publications

References 43 publications

Functionalized Fe-Doped Carbon Dots Exhibiting Dual Glutathione Consumption to Amplify Ferroptosis for Enhanced Cancer Therapy

Functionalized Fe-Doped Carbon Dots Exhibiting Dual Glutathione Consumption to Amplify Ferroptosis for Enhanced Cancer Therapy

Intense Blue Photo Emissive Carbon Dots Prepared through Pyrolytic Processing of Ligno-Cellulosic Wastes

Manganese-Doped N-Hydroxyphthalimide-Derived Carbon Dots—Theranostics Applications in Experimental Breast Cancer Models

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