Fe(III) improves antioxidant and cytoprotecting activities of mangiferin

Pardo-Andreu, Gilberto L.; Sánchez-Baldoquín, Carlos; Ávila-González, Rizette; Delgado, René; Naal, Zeki; Curti, Carlos

doi:10.1016/j.ejphar.2006.07.040

Cited by 57 publications

(34 citation statements)

References 30 publications

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“…5 shows that, in the presence of Fe(III), mangiferin has an approximately 2-fold higher capacity to scavenge the DPPH radical. Together, these results indicate that Fe(III) improves the scavenging activity of mangiferin toward ROS, including that on mitochondria, in agreement with our recent findings on superoxide scavenging and cytoprotection (Pardo-Andreu et al, 2006c). Therefore, scavenging of mitochondria-generated ROS is likely to contribute for the MPT-preventing capacity of the mangiferin-Fe(III) complex.…”

Section: Mangiferin-fe(iii) Complex Scavenges Mitochondrial Rossupporting

confidence: 80%

Fe(III) Shifts the Mitochondria Permeability Transition-Eliciting Capacity of Mangiferin to Protection of Organelle

Pardo-Andreu¹,

Cavalheiro²,

Dorta³

et al. 2006

J Pharmacol Exp Ther

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Mangiferin acts as a strong antioxidant on mitochondria. However, when in the presence of Ca 2ϩ , mangiferin elicits mitochondrial permeability transition (MPT), as evidenced by cyclosporin A-sensitive mitochondrial swelling. We now provide evidence, by means of electrochemical and UV-visible spectroscopical analysis, that Fe(III) coordinates with mangiferin. The resulting mangiferin-Fe(III) complex does not elicit MPT and prevents MPT by scavenging reactive oxygen species. Indeed, the complex protects mitochondrial membrane protein thiols and glutathione from oxidation. Fe(III) also significantly increases the ability of mangiferin to scavenge the 2,2-diphenyl-1-picrylhydrazyl radical, as well as to display antioxidant activity toward antimycin A-induced H 2 O 2 production and t-butyl hydroperoxide-promoted membrane lipid peroxidation in mitochondria. We postulate that coordination with Fe(III) constitutes a potential protective mechanism toward the prooxidant action of mangiferin and other catechol-containing antioxidants regarding MPT induction. Potential therapeutic relevance of this finding for conditions of pathological iron overload is discussed.

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Section: Mangiferin-fe(iii) Complex Scavenges Mitochondrial Rossupporting

confidence: 80%

Fe(III) Shifts the Mitochondria Permeability Transition-Eliciting Capacity of Mangiferin to Protection of Organelle

Pardo-Andreu¹,

Cavalheiro²,

Dorta³

et al. 2006

J Pharmacol Exp Ther

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“…Some studies have shown that MG may be endowed with a more efficient antioxidant activity when it is complexed with Fe +++ (Pardo-Andreu et al, 2006). Therefore, also this complex was investigated for its potential protective effects against As III -induced toxicity.…”

Section: Resultsmentioning

confidence: 99%

“…Comparable % of DMSO was used in experimental controls. Mangiferin/ Fe +++ complex was prepared according to Pardo-Andreu et al (2006).…”

Section: Plant Materials and Chemicalsmentioning

confidence: 99%

Polyphenols of Mangifera indica modulate arsenite-induced cytotoxicity in a human proximal tubule cell line

Garrido¹,

Romiti²,

Tramonti³

et al. 2012

Rev. bras. farmacogn.

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Inorganic arsenic is an ubiquitous environmental contaminant able to cause severe pathologies in humans, including kidney disorders. The possible protective effects of Mangifera indica L., Anacardiaceae, stem bark extract (MSBE) and some mango phenols on the cytotoxicity of arsenite (As III ) in the proximal tubule cell line HK-2 was investigated. In cells cultured for 24 h in presence of As III , a dose-dependent loss of cell viability occurred that was signifi cantly alleviated by MSBE, followed by gallic acid, catechin and mangiferin. Mangiferin complexed with Fe +++ proved more effi cacious than mangiferin alone. MSBE and pure phenols increased signifi cantly the cell surviving fraction in clonogenic assays. In cells pretreated with MSBE or phenols for 72 h the protection afforded by MSBE resulted decreased in comparison with the shorter experiments. Cells pretreated with a subcytotoxic amount of As III or cultured in continuous presence of low concentration of mangiferin proved to be more resistant to As III , while cells cultured in presence of albumin resulted more sensitive. Because all the above conditions share changes in expression/activity of P-glycoprotein (P-gp), a transporter potentially involved in arsenic resistance, the capability of M. indica phenols in modulating As III -induced cytotoxicity would be at least in part dependent on their interactions with P-gp.

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“…Phytochemicals present in this species include xanthones (Pardo-Andreu et al, 2006), norlignans (Iida et al, 2000;Park et al, 2003;Lim et al, 2009), and steroidal saponins (Nakashima et al, 1993;Sy et al, 2008;Ren et al, 2006;Wang et al, 2010), associated with…”

Section: Anemarrhena Asphodeloidesmentioning

confidence: 99%