Fe<sub>3</sub>O<sub>4</sub>@RB@LDH: Efficient and Recyclable Photocatalyst Visible‐Light Mediated Synthesis of Pyran and Pyrrolidinone Derivatives and Their Anti‐Microbial Activities

Dutta, Arup; Goswami, Munmee; Rabha, Jintu; Das, Sukanya; Jha, Dhruva Kumar; Nongkhlaw, Rishanlang

doi:10.1002/slct.202104075

Cited by 3 publications

(1 citation statement)

References 62 publications

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“…There are various methods for synthesizing pyranopyrazole derivatives, including direct reaction condensation or multi-component reactions in the presence of various catalysts. Examples of these catalysts include Fe2O3@SiO2@VB1 NPs [15], SiO2@Pr@SO3H [16], Na2SeO4 [17], (NH4)2HPO4 [18], and Fe3O4@RB@LDH [19].…”

Section: Introductionmentioning

confidence: 99%

TCS/ZnCl2 as a controlled reagent for the Michael addition and heterocyclic cyclization based on the phenyl pyrazolone scaffold with docking validation as a Covid-19 protease inhibitor

A. Almehizia,

M. Naglah,

A. Zen

et al. 2024

Bull. Chem. Soc. Eth.

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TCS/ZnCl2 is presented as a new catalyst for achieving the Michael addition adduct 5a-g by the reaction of phenyl pyrazolone 4 as the Michael donor and arylidene derivatives 3a-g as the Michael acceptor. The one-pot multi-component reaction of the same fragments' scaffolds as aldehydes 1a-g, malononitrile (2), and phenyl pyrazolone 4 with the same catalyst gives pyrano[2,3-c]pyrazole derivatives 6a-g as final products. The prepared compounds undergo docking validation as COVID-19 protease inhibitors and are compared with hydroxychloroquine as a reference drug. KEY WORDS: Pyranopyrazole, multi-component reactions, TCS/ZnCl2 catalyst, COVID-19, the energy score, hydroxychloroquine Bull. Chem. Soc. Ethiop. 2024, 38(4), 1119-1127. DOI: https://dx.doi.org/10.4314/bcse.v38i4.24

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Section: Introductionmentioning

confidence: 99%

TCS/ZnCl2 as a controlled reagent for the Michael addition and heterocyclic cyclization based on the phenyl pyrazolone scaffold with docking validation as a Covid-19 protease inhibitor

A. Almehizia,

M. Naglah,

A. Zen

et al. 2024

Bull. Chem. Soc. Eth.

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Reusable Magnetic Nanoparticles: A Green System for Synthesis of Pyrrole Scaffolds

Sharma,

Vaishali,

Pandey

et al. 2024

Journal of Heterocyclic Chem

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Nowadays, environmentally sustainable organic synthesis is demanding. In this context, nanoparticles are particularly interesting owing to their green synthesis aspects. Specifically, magnetic nanoparticles have been continuously utilized in organic synthesis for a decade. Among heterocycles, pyrrole and its analogs have a unique place due to its vast spectrum of applications. Derivatives of pyrrole help to find lead structures for new synthetic pharmaceutical compounds and other valuable compounds. Thus, magnetic nanoparticles accelerate organic chemists to develop pyrrole derivatives through green synthesis. Moreover, magnetic nanoparticles in pyrrole scaffold synthesis improve reaction efficiency and sustainability and create unique functional molecular hybrids for many scientific applications. This paper reviews the utilization of magnetic nanoparticles to afford a variety of valuable pyrrole derivatives, with a focus on their environmental friendliness.

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Synthesis of Tetrahydrobenzo[b]pyrans Catalyzed by 1,3-Dibenzyl-1H-benzo[d] imidazole-3-ium Chloride

Delfani,

Kiyani,

Zamani

2023

COC

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Tetrahydrobenzo[b]pyrans are fused oxygen-containing heterocycles that are found in many biologically active compounds. Therefore, researchers in organic synthesis are searching for suitable, efficient, and useful methods for their synthesis. In this contribution, a series of tetrahydrobenzo[b]pyran derivatives was synthesized using aryl aldehydes, malononitrile, and cyclohexane-1,3-dione or dimedone as the available starting materials. The three-component reactions were catalyzed by 1,3-dibenzyl-1H-benzo[d]imidazol-3-ium chloride as the N-heterocyclic carbene precursor. The heterocyclic oxygen-containing products were obtained in good to excellent isolated yields within relatively shorter reaction times. Optimizing the reaction conditions was performed from the point of view of various parameters of the reaction. The results of these experiments showed that the best solvent system includes water-ethanol, the most suitable reaction temperature is 60 ºC, and the optimal amount of the imidazolium catalyst loading is 5 mol%. Operational simplicity, no need for chromatographic methods for purification, simple work-up for pure products, and avoiding hazardous solvents are remarkable features of this three-component reaction. Moreover, in these multicomponent cyclo-condensations, no by-products were observed.

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Fe₃O₄@RB@LDH: Efficient and Recyclable Photocatalyst Visible‐Light Mediated Synthesis of Pyran and Pyrrolidinone Derivatives and Their Anti‐Microbial Activities

Cited by 3 publications

References 62 publications

TCS/ZnCl2 as a controlled reagent for the Michael addition and heterocyclic cyclization based on the phenyl pyrazolone scaffold with docking validation as a Covid-19 protease inhibitor

TCS/ZnCl2 as a controlled reagent for the Michael addition and heterocyclic cyclization based on the phenyl pyrazolone scaffold with docking validation as a Covid-19 protease inhibitor

Reusable Magnetic Nanoparticles: A Green System for Synthesis of Pyrrole Scaffolds

Synthesis of Tetrahydrobenzo[b]pyrans Catalyzed by 1,3-Dibenzyl-1H-benzo[d] imidazole-3-ium Chloride

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Fe3O4@RB@LDH: Efficient and Recyclable Photocatalyst Visible‐Light Mediated Synthesis of Pyran and Pyrrolidinone Derivatives and Their Anti‐Microbial Activities

Cited by 3 publications

References 62 publications

TCS/ZnCl2 as a controlled reagent for the Michael addition and heterocyclic cyclization based on the phenyl pyrazolone scaffold with docking validation as a Covid-19 protease inhibitor

TCS/ZnCl2 as a controlled reagent for the Michael addition and heterocyclic cyclization based on the phenyl pyrazolone scaffold with docking validation as a Covid-19 protease inhibitor

Reusable Magnetic Nanoparticles: A Green System for Synthesis of Pyrrole Scaffolds

Synthesis of Tetrahydrobenzo[b]pyrans Catalyzed by 1,3-Dibenzyl-1H-benzo[d] imidazole-3-ium Chloride

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Fe₃O₄@RB@LDH: Efficient and Recyclable Photocatalyst Visible‐Light Mediated Synthesis of Pyran and Pyrrolidinone Derivatives and Their Anti‐Microbial Activities