Fe3O4@iron-based metal–organic framework nanocomposite [Fe3O4@MOF (Fe) NC] as a recyclable magnetic nano-organocatalyst for the environment-friendly synthesis of pyrano[2,3-d]pyrimidine derivatives

Abstract

Various pyrano[2,3-d]pyrimidines were synthesized by the multicomponent reaction of aldehydes, malononitrile, and acidic C–H compounds such as barbituric acid through the tandem Knoevenagel–Michael cyclocondensation pathway in an environmentally friendly reactive medium in the presence of a recoverable nanocomposite. This nanocomposite includes Fe3O4 nanoparticles placed on an organometallic framework. The synthesized Fe3O4@iron-based metal–organic framework nanocomposite was characterized using scanning electron microscopy, energy dispersive X-ray spectroscopy, X-ray powder diffraction, a vibrating sample magnetometer, and thermogravimetric analysis.

Melamine phosphate-modified magnetic chitosan: a novel biocompatible catalyst for the synthesis of biological tetrahydrodipyrazolopyridine and pyrazolopyranopyrimidine derivatives

“…Amidst these advancements, the quest for promoting multicomponent reactions (MCRs) in the field of organic chemistry remains constant ( Sakthivel et al, 2023 ). These reactions, characterized by the coordinated arrangement of functional groups to form the desired structure, offer essential advantages such as one-pot synthesis, high atomic efficiency, and the production of valuable pharmaceutical compounds with excellent efficiency, attracting numerous researchers to this field ( Masoumi et al, 2020 ; Hootifard et al, 2023 ). Notably, the fusion of hetero polycycles represents one of the applications of multicomponent reactions, allowing for the synthesis of sophisticated structures at one step ( Zare et al, 2017 , Mohammadi Ziarani et al, 2022 ).…”