Fear, anxiety and depression in gastrointestinal stromal tumor (GIST) patients in the Netherlands: Data from a cross-sectional multicenter study

Psychological outcomes in patients with rare cancers: a systematic review and meta-analysis

“…The remaining 4249 studies were excluded after removing irrelevant studies with the wrong study design or population and duplicates. 23 studies 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 investigated patients diagnosed with sarcoma, eight studies 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 investigated patients diagnosed with various rare cancers, while one study 50 investigated patients diagnosed with cholangiocarcinoma. 57,470 patients with rare cancers out of 1,287,082 participants were included.…”

“…20 studies 19 , 21 , 22 , 23 , 26 , 27 , 28 , 33 , 34 , 35 , 36 , 38 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 50 were included to evaluate the prevalence of depression amongst patients with rare cancers. 1222 out of 6113 patients with rare cancers were assessed to have depression.…”

“…Five studies 35 , 36 , 41 , 44 , 46 were analysed to evaluate the relative risk of depression in patients with rare cancers. Meta-analysis of the five studies ( Fig.…”

“…4 A) indicated a statistically significant increased risk of depression in patients with rare cancers compared to the comparator arm (RR = 2.61, 95% CI: 1.43–4.77). Three studies 35 , 41 , 46 were analysed to evaluate the relative risk of anxiety in patients with rare cancers. Meta-analysis of the three studies ( Fig.…”