Fear of COVID-19, Anxiety and Depression in Patients with Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension during the Pandemic

Wieteska, Maria; Szmit, Sebastian; Florczyk, Michał; Kuśmierczyk‐Droszcz, Beata; Ryczek, Robert; Dzienisiewicz, Milena; Torbicki, Adam; Kurzyna, Marcin

doi:10.3390/jcm10184195

Cited by 19 publications

(33 citation statements)

References 46 publications

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“…In contrast to most previous studies, major depression was less frequent compared to patients with PAH and comparable to the general population ( 10 – 12 , 14 , 15 ). As in anxiety disorders, we assume that the better treatment opportunities and better prognosis in CTEPH might explain these findings.…”

Section: Discussioncontrasting

confidence: 96%

“…The prevalence of panic disorder in this study was comparable to previous findings in patients with other forms of PH ( 10 – 12 , 14 ). One reason for the significantly increased prevalence of panic disorders in patients with CTEPH compared to the general population might be that symptoms of dyspnea can be perceived as threatening, cause anxiety, and potentially leading to avoidance of potentially dyspnea evoking activities ( 27 ).…”

Section: Discussionsupporting

confidence: 89%

“…Additionally, the most commonly used questionnaire in the above mentioned studies ( 11 – 13 ) was the Patient Health Questionnaire 9 (PHQ-9) ( 34 ), which has already been found to overestimate the prevalence of major depression compared to SCID ( 35 ). Another explanation may be that in two studies in which the HADS was used, the cut-off value for depressive disorders was eight points ( 10 , 14 ). In our study, a cut-off value of 11 points was used, which was calculated as described.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies on the prevalence of mental disorders in patients with CTEPH almost exclusively focused on depression and anxiety (10)(11)(12)(13)(14)(15). The prevalence of these disorders ranged from 14.3 to 56.5% for depression and 4.1 to 43.5% for anxiety disorders.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of Mental Disorders in Patients With Chronic Thromboembolic Pulmonary Hypertension

et al. 2022

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ObjectivePulmonary hypertension (PH) is a chronic and progressive pulmonary vascular disease resulting in symptoms such as shortness of breath and fatigue and leading to death from right heart failure if not adequately treated. Chronic thromboembolic pulmonary hypertension (CTEPH) is a subgroup of PH characterized by obstruction or occlusion of pulmonary arteries by post-embolic fibrotic material. To date, few studies examined symptoms of depression and anxiety in patients with CTEPH, showing depression levels as high as 37.5%. However, none of the former studies used structured expert interviews.MethodsMental disorders were diagnosed using the Structured Clinical Interview for DSM-5 (SCID). The prevalence of mental disorders in patients with CTEPH were compared to the prevalence in patients with pulmonary arterial hypertension (PAH) and the general German population. Quality of life (QoL) was measured with World Health Organization (WHO) Quality of Life questionnaire (short form). Factors associated with QoL were analyzed with linear regression and the diagnostic value of the Hospital Anxiety and Depression Scale (HADS) was evaluated using receiver operating characteristics (ROC) curve analysis.ResultsHundred and seven patients with CTEPH were included. Almost one-third of the patients (31.8%) had current psychological disorders. Panic disorder (8.4%), specific phobia (8.4%), and major depressive disorder (6.5%) were the most prevalent mental illnesses. The prevalence of panic disorders was higher in CTEPH compared to the German population while major depressive disorder was fewer in CTEPH compared to PAH. The presence of mental disorders had a major impact on QoL. Hospital Anxiety and Depression Scale discriminated depression and panic disorder reliably.ConclusionMental disorders are common in patients with CTEPH and associated with an impaired QoL. The HADS may be a useful screening tool for panic and depression disorders in patients with CTEPH. Further research on therapeutic strategies targeting mental disorders in patients with CTEPH is needed.

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Section: Discussioncontrasting

confidence: 96%

Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prevalence of Mental Disorders in Patients With Chronic Thromboembolic Pulmonary Hypertension

et al. 2022

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“…The obtained results about the mental status of PAH/CTEPH patients during the pandemic have been described in another paper [14]. In the beginning, we wanted to assess the mental status of patients during the pandemic.…”

Section: Methodsmentioning

confidence: 96%

COVID-19 Vaccination in Patients with Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension: Safety Profile and Reasons for Opting against Vaccination

Wieteska¹,

Szmit²,

Florczyk³

et al. 2021

Vaccines

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The incidence of COVID-19 infection in patients with pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) is similar to that in the general population, but the mortality rate is much higher. COVID-19 vaccination is strongly recommended for PAH/CTEPH patients. The aim of our cross-sectional study was to identify reasons why PAH/CTEPH patients refused vaccination against COVID-19. Moreover, we assessed the safety profile of approved COVID-19 vaccines in PAH/CTEPH patients. We examined 261 patients (164 PAH patients and 97CTEPH patients) with a median age of 60 (18–92) years, 62% of which were female. Sixty-one patients (23%) refused to be vaccinated. The main reason for unwillingness to be vaccinated was anxiety about adverse events (AEs, 61%). Age and fear of COVID-19 in the univariate analysis and age ≥60 years in the multivariate regression analysis were factors that impacted willingness to be vaccinated (OR = 2.5; p = 0.005). AEs were reported in 61% of vaccinated patients after the first dose and in 40.5% after the second dose (p = 0.01). The most common reported AEs were pain at the injection site (54.5%), fever (22%), fatigue (21%), myalgia (10.5%), and headache (10%). A lower percentage of AEs was reported in older patients (OR = 0.3; p = 0.001). The COVID-19 vaccines are safe for PAH/CTEPH patients. The results obtained in this study may encourage patients of these rare but severe cardio-pulmonary diseases to get vaccinated against COVID-19.

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Auswirkungen einer Pandemie auf Menschen mit Seltenen Erkrankungen und Empfehlungen zur Aufrechterhaltung von Versorgung und Teilhabe

Zybarth,

Brandt,

Mundlos

et al. 2023

Bundesgesundheitsbl

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Zusammenfassung Hintergrund Seltene Erkrankungen sind häufig durch komplexe Beschwerdebilder charakterisiert und erfordern in der Regel im Diagnose- und Versorgungsverlauf die Koordination multiprofessioneller Behandlungsteams. Im Zuge der COVID-19-Pandemie veränderten sich die medizinische Versorgung und der Lebensalltag von Menschen mit einer Seltenen Erkrankung bzw. den Eltern bei minderjährigen Patient:innen drastisch. Das Projekt RESILIENT-SE-PAN („Retrospektive Analyse der Versorgungssituation und des Lebensalltags von Menschen mit Seltenen Erkrankungen während einer Pandemie und Ableitung von Handlungsempfehlungen“) hatte auf Grundlage verschiedener Perspektiven das Ziel, die Situation von Menschen mit einer Seltenen Erkrankung während der Pandemie zu erfassen und Empfehlungen abzuleiten. Methoden Es wurden quantitative und qualitative Befragungen aus Perspektive der Betroffenen bzw. der Angehörigen bei minderjährigen Patient:innen (i. d. R. Elternteil) und aus Perspektive von Vertreter:innen der Patient:innenorganisationen sowie ein Workshop durchgeführt (Mixed-Methods-Studie). Ergebnisse Es zeigten sich Auswirkungen auf die Versorgung und auf den Lebensalltag sowie psychische Belastungen der Befragten. Darüber hinaus wurden COVID-19-spezifische Aspekte, Unterstützungsbedarf und auch positive Aspekte berichtet. Auf Basis der umfassenden Ergebnisse wurden insgesamt 21 Empfehlungen in den folgenden 7 Bereichen formuliert: medizinische Diagnostik und Versorgung der Seltenen Erkrankung; ergänzende Therapien, Hilfs- und Heilmittel; Zugang zu Informationen und Impfungen bzgl. COVID-19; psychosoziale Unterstützung; Alltagshilfen/Teilhabe; Patient:innenorganisationen und Sonstiges/übergeordnete Aspekte. Diskussion Die formulierten Empfehlungen geben für künftige Krisen oder Pandemien wichtige Impulse, um die Situation von Menschen mit einer Seltenen Erkrankung adäquat zu berücksichtigen und entsprechend den Bedarfen der Betroffenen zu handeln.

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Fear of COVID-19, Anxiety and Depression in Patients with Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension during the Pandemic

Cited by 19 publications

References 46 publications

Prevalence of Mental Disorders in Patients With Chronic Thromboembolic Pulmonary Hypertension

Prevalence of Mental Disorders in Patients With Chronic Thromboembolic Pulmonary Hypertension

COVID-19 Vaccination in Patients with Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension: Safety Profile and Reasons for Opting against Vaccination

Auswirkungen einer Pandemie auf Menschen mit Seltenen Erkrankungen und Empfehlungen zur Aufrechterhaltung von Versorgung und Teilhabe

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