Fear of Pain Across the Adult Life Span

Wright, Casey D.; McNeil, Daniel W.

doi:10.1093/pm/pnaa390

Cited by 9 publications

(3 citation statements)

References 85 publications

(120 reference statements)

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“…Data for this study were obtained as part of a larger project designed to examine psychosocial correlates of oral health and disease 24 . The cross‐sectional data collection was conducted online via Qualtrics (Provo, UT) and utilized Amazon's Mechanical Turk (MTurk) for recruitment of a convenience sample of participants.…”

Section: Methodsmentioning

confidence: 99%

Gastrointestinal distress as a potential mediator between stress and periodontal inflammation

Wright

Heaton

García

et al. 2023

Comm Dent Oral Epid

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ObjectivesPeriodontal disease is multifactorial in its aetiology, which encompasses biopsychosocial contributors, including psychological stress. Gastrointestinal distress and dysbiosis have been associated with several chronic inflammatory diseases yet have rarely been investigated with respect to oral inflammation. Given the implications of gastrointestinal distress on extraintestinal inflammation, this study aimed to evaluate the potential role of such distress as a mediator between psychological stress and periodontal disease.MethodsUtilizing a cross‐sectional, nationwide sample of 828 adults in the USA generated via Amazon Mechanical Turk, we evaluated data collected from a series of validated self‐report psychosocial questionnaires on stress, gut‐specific anxiety around current gastrointestinal distress and periodontal disease, including periodontal disease subscales targeted at physiological and functional factors. Structural equation modelling was used to determine total, direct and indirect effects, while controlling for covariates.ResultsPsychological stress was associated with gastrointestinal distress (ß = .34) and self‐reported periodontal disease (ß = .43). Gastrointestinal distress also was associated with self‐reported periodontal disease (ß = .10). Gastrointestinal distress likewise mediated the relation between psychological stress and periodontal disease (ß = .03, p = .015). Given the multifactorial nature of periodontal disease(s), similar results were demonstrated using the subscales of the periodontal self‐report measure.ConclusionsAssociations exist between psychological stress and overall reports of periodontal disease as well as more specific physiological and functional components. Additionally, this study provided preliminary data supporting the potential mechanistic role that gastrointestinal distress plays in connecting the gut–brain and the gut–gum pathways.

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Section: Methodsmentioning

confidence: 99%

Gastrointestinal distress as a potential mediator between stress and periodontal inflammation

Wright

Heaton

García

et al. 2023

Comm Dent Oral Epid

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“…Furthermore, a blood sample will be taken at screening visit in order to identify COMT polymorphisms by PCR analysis. In addition, (1) treatment expectation will be assessed by the Treatment Expectation Questionnaire (TEX-Q 42 ), which distinguished between symptomspecific effects and effects related to quality of life and functional capability; (2) fear of pain by the Fear of Pain Questionnaire 43 ; (3) pain catastrophising by the Pain Catastrophizing Scale, 44 as these personality traits have been shown to be positively related to subjective pain intensity and fear of pain has further been shown to be the most robust predictor of pain chronification [45][46][47] ; (4) personality traits using the Behavioral Inhibition and Approach System [48][49][50] and the Short Version of the Big Five Inventory 51 due to the close link between personality traits associated to dopamine release, reward processing and expectation effects of treatment outcome 52 ; (5) anxiety and depression by the State-Trait Anxiety Depression Inventory 53 and stress by the Perceived Stress Scale 54 as depression, anxiety and psychological distress have been reported to be susceptible to modulation through OLP treatment 7 55 ; and (6) somatisation by the Somatosensory Amplification Scale 56 as a predictive role of somatosensory amplification in the development of side effects or negative expectation effects has been observed. 41 54 57 Further, a questionnaire (Generic Rating for Treatment Pre-experiences, Treatment Expectations, and Treatment…”

Section: Recruitmentmentioning

confidence: 99%

Impact of a 12-week open-label placebo treatment on headache days in episodic and chronic migraine: a study protocol for a parallel-group, multicentre, randomised controlled trial

Schmidt¹,

Kleine-Borgmann²,

Holle-Lee³

et al. 2021

BMJ Open

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IntroductionMigraine is the most common neurological disorder and one of the major causes of years lived with disability. Its treatment (especially of chronic forms) is often challenging and accompanied with adverse effects. Although new therapeutic approaches have recently emerged (eg, calcitonin gene-related peptide antibodies), these are linked to strict prescribing guidelines and therefore limited to only a minority of patients. Recently, randomised controlled trials have demonstrated that open-label placebo treatments can lead to significant and clinically relevant improvements of chronic pain conditions.Methods and analysisThis multicentre, randomised controlled clinical trial following a parallel group between-subject design aims to systematically investigate the impact of a 12-week open-label placebo treatment on moderate to severe headache days (primary outcome) in patients with episodic and chronic migraine in addition to treatment as usual. Secondary outcomes comprise the number of migraine days, pain intensity, intake of acute medication, quality of life, disability, global impression of change, tolerability and a responder rate. To systematically address potential predictors of placebo responses in patients with migraine, this study assesses potential psychometric predictors, salivary cortisol and alpha-amylase awakening responses, catechol-o-methyltransferase Val158Met polymorphisms, as well as functional and structural brain connectivity (ie, resting state functional MRI, diffusion tensor imaging). The data analysis will be performed on basis of the general linear model considering repeated measures (mixed model).Ethics and disseminationThis protocol and all corresponding documents were approved with regard to their content and compliance with ethical regulations by the Ethics Committee of the Medical Faculty of the University Duisburg-Essen, Germany and the Ethics Committee of the Landesärztekammer Hessen. The results from this study will be actively disseminated through manuscript publications and conference presentations.Trial registration numberGerman Clinical Trials Register (DRKS00021259).

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“…These sensations may be directly associated or determined by a person's different psychological features, which makes our brain a major actor in pain perception, since it is responsible to process the feelings that run through our bodies after painful events [ 1 ]. Painful memories of past events lead to a type of personality traits called fear of pain (FOP) [ 2 ], that can be described as the verbal, physiological and overt behavior responses to potential or anticipated painful experiences [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Fear of Pain as a Predictor for Postoperative Pain Intensity among the Patients Undergoing Thoracoscopic Surgery

Luo

Bao

et al. 2022

Pain Research and Management

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Setting. Thoracic surgery department of a tertiary hospital. Background. Fear of pain (FOP) has been recognized as an influential moderator and determinant of the perception and disability of chronic pain. However, studies on FOP in postoperative acute pain are few and inconsistent. Objective. To explore whether FOP is related to pain intensity after thoracic surgery and provide a reference for FOP study in postoperative pain. Methods. From February to March 2022, 89 patients completed Chinese Version of Fear of Pain-9 Items (FOP-9), Chinese version of the Brief Pain Inventory (BPI, including least, worst, and average pain) and Simplified Chinese version of the Pain Catastrophizing Scale (PCS). Correlation analyses and mediation analyses were used for exploring the relationship between factors. Results. Mediation analyses showed that the total effects of FOP-9 on BPI all were significant (least pain: effect = 0.085, p = 0.013 , 95% CI = 0.019∼0.151; worst pain: effect = 0.116, p = 0.004 , 95% CI = 0.037∼0.196; average pain: effect = 0.102, p = 0.005 , 95% CI = 0.031∼0.174) indicating that FOP-9 was a predictor to BPI. The 95% bias-corrected bootstrap confidence interval of estimate of indirect effect between FOP-9 and least pain/average pain through PCS was −0.036∼0.024 and −0.003∼0.069 (all contain zero), which indicated that PCS is not a mediator between FOP-9 and least pain/average pain. However, the estimate of indirect effect between FOP-9 and worst pain through PCS were 0.048 (95% CI = 0.095∼0.088), and direct effect was not statistically significant (95% CI = −0.017∼0.153), indicating that PCS acted as a complete intermediary between FOP-9 and worst pain. FOP-9 and PCS showed significant positive prediction effect on worst pain. Conclusions. Both trait FOP and state FOP were associated with higher postoperative pain reports after thoracic surgery. Trait FOP influences postoperative pain through the mediating effect of state FOP.

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Fear of Pain Across the Adult Life Span

Cited by 9 publications

References 85 publications

Gastrointestinal distress as a potential mediator between stress and periodontal inflammation

Gastrointestinal distress as a potential mediator between stress and periodontal inflammation

Impact of a 12-week open-label placebo treatment on headache days in episodic and chronic migraine: a study protocol for a parallel-group, multicentre, randomised controlled trial

Fear of Pain as a Predictor for Postoperative Pain Intensity among the Patients Undergoing Thoracoscopic Surgery

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