Feasibility and acceptability of time-restricted eating in a group of adults with multiple sclerosis

Wingo, Brooks C.; Rinker, John R.; Green, Kathryn; Peterson, Courtney M.

doi:10.3389/fneur.2022.1087126

Cited by 10 publications

(9 citation statements)

References 37 publications

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“…MS is associated with immune cell activation and neuroinflammation; RRMS subjects undergoing 12-weeks of iCR had reduced leptin levels, an adipokine with a known role in activating immune cells and inflammation. This trial and several prior clinical studies in pwMS indicate that daily or intermittent CR is feasible and improves subjective clinical measures 6 24 25 . Furthermore, it adds to existing literature by showing objective effects on metabolic and immunologic biomarkers, not previously extensively investigated and with a potential beneficial impact on disease pathogenic mechanisms.…”

Section: Discussionmentioning

confidence: 62%

Randomized Controlled Trial of Intermittent Calorie Restriction in People With Multiple Sclerosis

Ghezzi,

Tosti,

Shi

et al. 2024

Preprint

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Background and objectives: Calorie restriction (CR) ameliorates preclinical models of multiple sclerosis (MS) through reduction of inflammation via multiple mechanisms including reduced adiposity and changes in pro-inflammatory adipokine levels. Daily and intermittent CR (iCR) have been tested in people with MS (pwMS) with benefits shown on fatigue and wellbeing measures. The aim of this trial was to study the effects of 12-week iCR on metabolic, immunological and clinical outcomes in pwMS. Methods: Participants with relapsing-remitting MS were randomly assigned to iCR or a control group for 12 weeks. Anthropometric measures, clinical and patient-reported outcomes, and blood samples were collected at baseline, 6 and 12 weeks. Oral glucose tolerance test and dual-energy X-ray absorptiometry were performed at baseline and week 12. Primary outcome of the study was change in leptin serum levels; secondary outcomes included changes in anthropometric and body composition measures, peripheral blood metabolic and immunologic profiling, and clinical measures. Mixed effects linear regression models were used to evaluate differences in the outcomes of interest between and within groups over time. Results: Forty-two pwMS were randomized, 34 completed the study (17 iCR and 17 control). Leptin levels decreased over the course of the study in the iCR group and were significantly lower in the iCR than the control group at 6 (mean difference 11.49 ug/dL, 95% CI 32.54, 9.54; P=0.01) and 12 weeks (6.97 ug/dL, 95% CI 28.02, 14.06; P=0.03). Adiponectin increased from baseline in the iCR, but not in the control cohort. We observed a significant reduction of weight, body mass index and body adiposity measures over the 6 and 12-weeks in participants randomized to iCR. Immune profiling showed a significant increase in CD45RO+ regulatory T cell numbers after 6 weeks of iCR. Lysophosphatidylcholine, lysophophatidylethanolamine and phosphatidylinositol lipids species were significantly increased after 12 weeks in the iCR group compared to baseline, and all three were higher at 12 weeks compared to controls. Exploratory cognitive testing demonstrated improvement in the symbol digit modality test score in the iCR group. Conclusions: Short term iCR is safe, feasible and can benefit metabolic and immunologic profiles in pwMS.

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Section: Discussionmentioning

confidence: 62%

Randomized Controlled Trial of Intermittent Calorie Restriction in People With Multiple Sclerosis

Ghezzi,

Tosti,

Shi

et al. 2024

Preprint

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“…Wingo et al ( 52 ) conducted a pilot study to investigate the feasibility and acceptability of a TRE protocol among adults with RRMS. Throughout the 8-week trial, participants ( n = 12) were required to consume their daily food intake within an 8-h window and fast for the remaining 16 h. The study found a high retention rate and overall adherence, with participants maintaining the eating pattern on average > 6.5 days/week, and noted qualitative improvements in various aspects like sleep, fatigue, and overall wellbeing.…”

Section: Resultsmentioning

confidence: 99%

“…The rigors of strict calorie limitation often deter continued compliance, underscoring the necessity for more accessible dietary interventions. Contrastingly, TRE emerges as a more user-friendly alternative, as documented by Wingo et al ( 52 )., offering substantive metabolic and physiological shifts akin to those prompted by more stringent CR methods, without the associated adherence hurdles. The comparative ease and significant outcomes of TRE could potentially translate into a higher patient adherence rate, thereby making it a more sustainable option for long-term dietary management in MS.…”

Section: Discussionmentioning

confidence: 99%

The effects of intermittent fasting for patients with multiple sclerosis (MS): a systematic review

Lin,

Wang,

Gao

2024

Front. Nutr.

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Some studies have investigated the impact of intermittent fasting (IF) for patients with multiple sclerosis (MS). We aimed to conduct a comprehensive systematic review to analyze and summarize all clinical studies concerning the effects of IF on patients with MS. We conducted an exhaustive review of information available in the Embase, Cochrane, and PubMed databases up until 1 September 2023. All clinical research relating to the impacts of IF for patients with MS were included. In total, this systematic review encompassed 5 studies, which included four RCTs and one pilot study. Each study involved was assessed of high quality. The results from these studies demonstrate that IF protocols could potentially serve as an effective dietary strategy for managing symptoms and improving the quality of life in individuals afflicted with MS. In conclusion, IF might be a potential beneficial dietary intervention for MS. However, the number of trials in this field is relatively limited. The large-scale clinical trials to investigate the effects of IF for MS are urgently needed, which may be helpful to manage this intricate neuroimmune disorder.Systematic review registrationhttps://inplasy.com, identifier INPLASY2023100021.

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“…21 Three reported each of the three assessments used for MSFC calculations but did not report MSFC scores. 20,22,23 The fifth reported that significant within-group MSFC improvements occurred in the plant-based low-fat intervention group over 12 months, but no differences were observed Multiple Sclerosis Journal-Experimental, Translational and Clinical compared to the control group. 24 Due to the potential effect of exercise on MSFC, the findings from the fifth trial are confounded due to the inclusion of an exercise intervention in both groups.…”

Section: Discussionmentioning

confidence: 99%

“…18 A recent retrospective analysis observed an association between higher Mediterranean diet adherence and decreased functional disability as assessed by the MSFC 19 ; however, prospective studies investigating the effect of dietary intervention on the MSFC are sparse and limited by methodological or reporting issues. [20][21][22][23][24] Therefore, the objectives of this secondary analysis of the WAVES trial were to evaluate the effects of the Swank and Wahls diets on functional disability and explore the influence of fatigue on changes in functional disability among individuals with RRMS.…”

Section: Introductionmentioning

confidence: 99%

Diet-induced changes in functional disability are mediated by fatigue in relapsing-remitting multiple sclerosis: A secondary analysis of the WAVES randomized parallel-arm trial

Crippes,

Saxby,

Shemirani

et al. 2023

Multiple Sclerosis Journal - Experimental, Translational and Cl

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Background People with multiple sclerosis (MS) often report dietary modifications; however, evidence on functional outcomes remains sparse. Objective Evaluate the impact of the low-saturated fat (Swank) and modified Paleolithic elimination (Wahls) diets on functional disability among people with relapsing-remitting MS. Methods Baseline-referenced MS functional composite (MSFC) scores were calculated from nine-hole peg-test (NHPT), timed 25-foot walk, and oral symbol digit modalities test (SDMT-O) collected at four study visits: (a) run-in, (b) baseline, (c) 12 weeks, and (d) 24 weeks. Participants were observed at run-in and then randomized at baseline to either the Swank ( n = 44) or Wahls ( n = 43) diets. Results Among the Swank group, MSFC scores significantly increased from −0.13 ± 0.14 at baseline to 0.10 ± 0.11 at 12 weeks ( p = 0.04) and 0.14 ± 0.11 at 24 weeks ( p = 0.02). Among the Wahls group, no change in MSFC scores was observed at 12 weeks from 0.10 ± 0.11 at baseline but increased to 0.28 ± 0.13 at 24 weeks ( p = 0.002). In both groups, NHPT and SDMT-O z-scores increased at 24 weeks. Changes in MSFC and NHPT were mediated by fatigue. Discussion Both diets reduced functional disability as mediated by fatigue. Trial Registration Clinicaltrials.gov Identifier: NCT02914964

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Feasibility and acceptability of time-restricted eating in a group of adults with multiple sclerosis

Cited by 10 publications

References 37 publications

Randomized Controlled Trial of Intermittent Calorie Restriction in People With Multiple Sclerosis

Randomized Controlled Trial of Intermittent Calorie Restriction in People With Multiple Sclerosis

The effects of intermittent fasting for patients with multiple sclerosis (MS): a systematic review

Diet-induced changes in functional disability are mediated by fatigue in relapsing-remitting multiple sclerosis: A secondary analysis of the WAVES randomized parallel-arm trial

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