to support the global strategy to reduce risk factors for obesity, we synthesized the evidence on physical activity (pA) and sedentary behaviour in the Middle east and north Africa (MenA) region. Our systematic overview included seven systematic reviews reporting 229 primary studies. The metaanalysis included 125 prevalence measures from 20 MENA countries. After 2000, 50.8% of adults (ranging from 13.2% in Sudan to 94.9% in Jordan) and 25.6% of youth (ranging from 8.3% in Egypt to 51.0% in Lebanon) were sufficiently active. Limited data on PA behaviours is available for MENA countries, with the exception of Gulf Cooperation Council countries. The meta-regression identified gender and geographical coverage among youth, and the pA measurement as predictors of pA prevalence for both adults and youth. Our analysis suggests a significant PA prevalence increase among adults over the last two decades. the inconsistency in sedentary behaviour measurement is related to the absence of standardized guidelines for its quantification and interpretation. The global epidemic of insufficient PA is prevalent in MENA. Lower PA participation among youth and specifically females should be addressed by focused lifestyle interventions. the recognition of sedentary behaviour as a public health issue in the region remains unclear. Additional data on pA behaviours is needed from lowand middle-income countries in the region. Non-communicable diseases (NCDs) kill 41 million people worldwide each year-equivalent to 71% of all deaths 1. The Middle East and North Africa (MENA) region has one of the highest rates of NCDs in the world. In 2017, the region reported the second highest prevalence of diabetes in the world (10.8%) 2 and is recording a rapid increase in obesity 3,4. Insufficient physical activity (PA) and sedentary behaviour are key risk factors for obesity and other NCDs 5-15 leading to premature mortality 10,11,16-18. It has been suggested that PA has the potential to effectively control and reduce the burden of obesity during the various phases of human development 19. Regular PA can also improve self-esteem, cognitive performance, and academic achievement in young people 7,20,21 and is positively related to cardiorespiratory and metabolic health 6. Recently, sedentary behaviour has received global attention as prolonged sedentary time is associated with an increased risk of chronic disease and an increase in all-cause mortality, regardless of individuals meeting the recommended levels of PA 13,15. The World Health Organization (WHO) and the Global Observatory for Physical Activity (GoPA) are targeting a relative reduction of 10% in the global prevalence of physical inactivity among adults by 2025 22,23. Currently, one of the most pressing needs to improve population health is to develop appropriate policies and implement interventions to address the global pandemic of physical inactivity 24,25. However, to support this action, country-level evidence on PA behaviour in various population groups is essential. Both regional-and coun...