Feasibility and Accuracy of Ultrasound‐guided Sacroiliac Joint Injection in Dogs

Jones, Jeryl C.; González, Luis Miguel Redondo; Larson, Martha M.; Freeman, Lisa C.; Werre, Stephen R.

doi:10.1111/j.1740-8261.2011.01920.x

Cited by 11 publications

(22 citation statements)

References 33 publications

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“…The bony anatomic landmarks used in this study were L7, S1, and the iliac wings. US features of the explored area were similar to previous US description of caudal lumbar region, sacro‐iliac joint or epidural space . In agreement with a previous study, clear visualization of nervous structures within the vertebral canal was variable and depended on dog's size, fat or skin quality.…”

Section: Discussionsupporting

confidence: 89%

Feasibility of Ultrasound‐guided Epidural Access at the Lumbo‐sacral Space in Dogs

Liotta

Busoni

Carrozzo

et al. 2014

Vet Radiology Ultrasound

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Epidural injections are commonly performed blindly in veterinary medicine. The aims of this study were to describe the lumbosacral ultrasonographic anatomy and to assess the feasibility of an ultrasound-guided epidural injection technique in dogs. A cross sectional anatomic atlas of the lumbosacral region and ex vivo ultrasound images were obtained in two cadavers to describe the ultrasound anatomy and to identify the landmarks. Sixteen normal weight canine cadavers were used to establish two variations of the technique for direct ultrasound-guided injection, using spinal needles or epidural catheters. The technique was finally performed in two normal weight cadavers, in two overweight cadavers and in five live dogs with radiographic abnormalities resulting of the lumbosacral spine. Contrast medium was injected and CT was used to assess the success of the injection. The anatomic landmarks to carry out the procedure were the seventh lumbar vertebra, the iliac wings, and the first sacral vertebra. The target for directing the needle was the trapezoid-shaped echogenic zone between the contiguous articular facets of the lumbosacral vertebral canal visualized in a parasagittal plane. The spinal needle or epidural catheter was inserted in a 45° craniodorsal-caudoventral direction through the subcutaneous tissue and the interarcuate ligament until reaching the epidural space. CT examination confirmed the presence of contrast medium in the epidural space in 25/25 dogs, although a variable contamination of the subarachnoid space was also noted. Findings indicated that this ultrasound-guided epidural injection technique is feasible for normal weight and overweight dogs, with and without radiographic abnormalities of the spine.

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Section: Discussionsupporting

confidence: 89%

Feasibility of Ultrasound‐guided Epidural Access at the Lumbo‐sacral Space in Dogs

Liotta

Busoni

Carrozzo

et al. 2014

Vet Radiology Ultrasound

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“…As shown in Figure 5B, pretreatment of IHH cells with cyclohexamide did not alter the transcriptional response of TTPA to hydrogen peroxide, indicating that TTPA expression is regulated by already-present transcription factor(s) which respond to oxidative stress. In light of two putative NF-κB binding sites in the TTPA promoter (Figure 3A), and the established oxidative stress-responsiveness of this transcription factor (66), we examined the possible involvement of NF-κB in the transcriptional response of TTPA to H 2 O 2 . Treatment of IHH cells with the NF-κB inhibitor Bay 11-7085 (67,68) did not abrogate the transcriptional response of TTPA expression to oxidative stress (data not shown), indicating that a transcription factor other than NF-κB mediates this response.…”

Section: Resultsmentioning

confidence: 99%

Expression of the α-tocopherol transfer protein gene is regulated by oxidative stress and common single-nucleotide polymorphisms

Ulatowski

Dreussi

Noy

et al. 2012

Free Radical Biology and Medicine

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Vitamin E (α-tocopherol) is the major lipid soluble antioxidant in most animal species. By controlling the secretion of vitamin E from the liver, the α-tocopherol transfer protein (αTTP) regulates whole-body distribution and levels of this vital nutrient. However, the mechanism(s) that regulate the expression of this protein are poorly understood. Here we report that transcription of the TTPA gene in immortalized human hepatocytes (IHH) is induced by oxidative stress and by hypoxia, by agonists of the nuclear receptors PPARα and RXR, and by increased cAMP levels. The data show further that induction of TTPA transcription by oxidative stress is mediated by an already-present transcription factor, and does not require de novo protein synthesis. Silencing of the cAMP response element binding (CREB) transcription factor attenuated transcriptional responses of the TTPA gene to added peroxide, suggesting that CREB mediates responses of this gene to oxidative stress. Using a 1.9 Kb proximal segment of the human TTPA promoter together with site-directed mutagenesis approach, we found that single nucleotide polymorphisms (SNPs) that are commonly found in healthy humans dramatically affect promoter activity. These observations suggest that oxidative stress and individual genetic makeup contribute to vitamin E homeostasis in humans. These findings may explain the variable responses to vitamin E supplementation observed in human clinical trials.

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“…The study was a retrospective, secondary analysis, methods comparison design. Archived image data were retrieved from a previous, prospective research study on ultrasound‐guided canine sacroiliac joint injections . Institutional Animal Care and Use Committee approval had been granted for the previous prospective study and was not required for the current retrospective study.…”

Section: Methodsmentioning

confidence: 99%

“…As part of the inclusion criteria for the current study, all cadaver specimens had to have been collected and imaged using the following standardized protocol . Specimens had been collected immediately after euthanasia and included the caudal lumbar spinal region, pelvic region, and hindlimbs.…”

Section: Methodsmentioning

confidence: 99%

“…Joint injections are established methods for diagnosing and treating sacroiliac joint disease in humans . While ultrasound‐guided sacroiliac joint injections have been tested in canine cadavers, no report describing this method in live dogs was found at the time of this study . Radiography is a noninvasive, widely available, and relatively inexpensive method for detecting sacroiliac disease in dogs; however, the complex surfaces of the joint can be difficult to completely evaluate due to superimposition, and angulation of the X‐ray beam can affect lesion detection .…”

Section: Introductionmentioning

confidence: 99%

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CT and gross pathology are comparable methods for detecting some degenerative sacroiliac joint lesions in dogs

Carnevale

Jones

Holásková

et al. 2019

Vet Radiology Ultrasound

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Degenerative sacroiliac joint disease is a cause of lumbosacral pain in dogs; however, published information on cross‐sectional imaging characteristics is limited. Objectives of this retrospective, secondary analysis, methods‐comparison study were to test hypotheses that CT lesions reported in humans with degenerative sacroiliac joint disease are also present in dogs, and that CT is comparable to gross pathology for detecting these lesions. Matched CT and gross pathology slice images of 30 sacroiliac joints were retrieved from a previous prospective, canine cadaver study. A veterinary radiologist interpreted randomized CT images for each joint based on previously published CT characteristics of lesions in humans with degenerative sacroiliac joint disease. A veterinary pathologist independently interpreted randomized gross pathology images using the same criteria. All joints had at least one CT lesion consistent with degenerative sacroiliac joint disease. A new CT lesion was also identified and termed “subarticular cleft.” The CT and gross pathology methods agreed for detecting joints with subchondral sclerosis, subchondral erosion, and intra‐articular ankylosis lesions (P > .05, McNemar's test), but disagreed for detection of joints with subchondral cyst, para‐articular ankylosis, and subarticular cleft lesions (P ≤ .05). Using gross pathology as the reference standard, CT had 100% sensitivity for detection of subarticular cleft and subchondral cyst lesions, with 56% and 22% specificity, respectively. Para‐articular ankylosis lesions were detected by CT but not by gross pathology. Findings supported the hypothesis that CT lesions reported in humans with degenerative sacroiliac joint disease are also present in dogs, and partially supported the hypothesis that CT is comparable to gross pathology for detecting joints with these lesions.

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Feasibility and Accuracy of Ultrasound‐guided Sacroiliac Joint Injection in Dogs

Cited by 11 publications

References 33 publications

Feasibility of Ultrasound‐guided Epidural Access at the Lumbo‐sacral Space in Dogs

Feasibility of Ultrasound‐guided Epidural Access at the Lumbo‐sacral Space in Dogs

Expression of the α-tocopherol transfer protein gene is regulated by oxidative stress and common single-nucleotide polymorphisms

CT and gross pathology are comparable methods for detecting some degenerative sacroiliac joint lesions in dogs

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