Feasibility and Activity of Sorafenib and Sunitinib in Advanced Penile Cancer: A Preliminary Report

Zhu, Yushan; Li, Hui; Yao, Xu; Zhang, Shi Lin; Zhang, Hai Liang; Shi, Guo Hai; Li, Yang; Yang, Zhong; Wang, Chao‐Fu; Ye, Ding Wei

doi:10.1159/000315432

Cited by 37 publications

(14 citation statements)

References 33 publications

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“…Lack of multicenter studies hinders proper evaluation of these predictive indicators with adequate statistical power. Furthermore, few reports discussed the predictive value of histopathological features (such as p53 expression and tumor deposit) of metastatic lymph nodes 19 [ , 41,51,52] . Patients with sentinel lymph node positive disease are still lack of valuable prognostic factors to stratify long-term outcome.…”

Section: N0mentioning

confidence: 99%

Lymph node metastases and prognosis in penile cancer

Zhu

2012

Chin. J. Cancer Res.

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Lymph node status is a key prognostic factor in penile squamous cell carcinoma. Recently, growing evidence indicates a multimodality approach consisting of neoadjuvant chemotherapy followed by consolidation surgery improves the outcome of locally advanced penile cancer. Thus, accurate estimation of survival probability in node-positive penile cancer is critical for treatment decision making, counseling of patients and follow-up scheduling. This article reviewed evolving developments in assessing the risk for cancer progression based on lymph node related variables, such as the number of metastatic lymph nodes, bilateral lymph node metastases, the ratio of positive lymph nodes, extracapsular extension of metastatic lymph nodes, pelvic lymph node metastases, metastatic deposit in sentinel lymph nodes and N stage in TNM classification. Controversial issues surrounding the prognostic value of these nodal related predictors were also discussed.

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Section: N0mentioning

confidence: 99%

Lymph node metastases and prognosis in penile cancer

Zhu

2012

Chin. J. Cancer Res.

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“…Zhu et al evaluated the efficacy of kinase inhibitors (sorafenib and sunitinib) in 6 patients who had previously received at least two chemotherapy regimens. One partial response and 4 stable disease responders were observed [ 53 ]. Additionally, cytotoxic agents such as paclitaxel, which have antiangiogenic effects when administered at low doses, along with other antiangiogenics have shown activity in melanoma and urothelial carcinomas.…”

Section: Current Established and Emerging Targets Of Therapymentioning

confidence: 99%

Advances in Understanding of Penile Carcinogenesis: The Search for Actionable Targets

Chipollini

Chaing

Azizi

et al. 2017

IJMS

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Penile cancer (PeCa) is a rare malignancy with potentially devastating effects. Squamous cell carcinoma is the most common variant with distinct precancerous lesions before development into invasive disease. Involvement of the inguinal lymph nodes is the most important prognostic factor in PeCa, and once disease is present outside the groin, prognosis is poor. Metastatic PeCa is challenging to treat and often requires multidisciplinary approaches in management. Due to its rarity, molecular understanding of the disease continues to be limited with most studies based on small, single center series. Thus far, it appears PeCa has diverse mechanisms of carcinogenesis affecting similar molecular pathways. In this review, we evaluate the current landscape of the molecular carcinogenesis of PeCa and explore ongoing research on potential actionable targets of therapy. The emergence of anti-epidermal growth factor receptor (EGFR) and other immunotherapeutic strategies may improve outcomes for PeCa patients.

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“…Second-line chemotherapy with taxanes is marginally active with a median survival of ∼6 months [11]. Epidermal growth factor receptor (EGFR) inhibitors and vascular endothelial growth factor (VEGF) inhibitors have exhibited signals of modest activity [12–15]. Hence, substantial advances in systemic therapy are likely to emerge only if trials are informed by improved knowledge of biology.…”

Section: Introductionmentioning

confidence: 99%

Kinase analysis of penile squamous cell carcinoma on multiple platforms to identify potential therapeutic targets

Yang

Willey

Mehta³

et al. 2017

Oncotarget

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Penile squamous cell carcinoma (PSCC) is an orphan malignancy with poorly understood biology and suboptimal systemic therapy. Given that kinases may be drivers and readily actionable, we performed comprehensive multiplatform analysis of kinases in PSCC tumor and normal tissue. Fresh frozen tumors were collected from 11 patients with PSCC. After macrodissection to demarcate tumor from normal tissue, the samples underwent multiplatform analysis of kinases. Next Generation Sequencing (NGS) of 517 kinase genes was performed using Agilent Kinome capture and run on the Illumina MiSeq at PE150bp. The NanoString nCounter® platform analyzed the expression of 519 kinase genes. Kinase activity of tissue lysates was measured using PamStation®12 high-content phospho-peptide substrate microarray system. Network mapping was done with GeneGo MetaCore™ and upstream kinase prediction was performed with BioNavigator and the Kinexus database. Ingenuity pathway analysis was performed to integrate elevated kinase activity and gene over-expression with coexisting missense mutations at DNA level. Top pathways upregulated in both the kinase activity and gene expression platforms were PTEN, STAT3, GNRH, IL-8 and B cell receptor signaling. Potentially relevant missense mutations were seen in 176 kinase genes, with the top altered pathways overlapping with gene overexpression being GNRH, NF-kB and STAT3 signaling. ERBB2, ERBB3 and SYK were altered on NGS and also exhibited elevated kinase activity. To summarize, multiplatform comprehensive analysis of kinases discovered potential drivers of PSCC and actionable therapeutic targets. Translational studies are necessary to validate the functional relevance of our data to make advances in this rare malignancy.

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Feasibility and Activity of Sorafenib and Sunitinib in Advanced Penile Cancer: A Preliminary Report

Cited by 37 publications

References 33 publications

Lymph node metastases and prognosis in penile cancer

Lymph node metastases and prognosis in penile cancer

Advances in Understanding of Penile Carcinogenesis: The Search for Actionable Targets

Kinase analysis of penile squamous cell carcinoma on multiple platforms to identify potential therapeutic targets

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