Feasibility and effectiveness of unintended pregnancy prevention with low-dose mifepristone combined with misoprostol before expected menstruation

Li, Cuilan; Chen, Dunjin; Deng, Yifan; Song, Li-Ping; Mo, Xue-Tang; Liu, Kai-Jie

doi:10.1093/humrep/dev239

Cited by 5 publications

(5 citation statements)

References 30 publications

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“…24 Unscheduled reattendance, a particular concern related to self-administration, was infrequent, and the rate did not differ between groups, consistent with the report that selfadministration of a medical abortion regimen did not increase the unscheduled reattendance rate. 22 Based on the results of the present study in 2015-along with low-dose mifepristone (50 mg) and misoprostol (200 mg) at the time of expected menstruation being under the supervision of professional doctors 23 -we now suggest that the use of low-dose mifepristone (75 mg) and self-administered misoprostol (400 mg) is highly acceptable for ultra-early medical abortion.…”

Section: Safety and Feasibility Of Self-administration Of A Low-dose Medical Abortion Regimenmentioning

confidence: 61%

“…4,5 Our 2015 study showed that menstrual regulation with low-dose mifepristone (50 mg) and misoprostol (200 mg) at the expected time of menstruation was efficacious and highly acceptable for the maintenance or restoration of nonpregnant status and may have potential for routine contraception. 23 As the fields of general practice and family medicine are often only in the beginning stages of development, the amount of supervision required for medical abortion, especially ultra-early pregnancy termination, remains a matter of debate. 10 A highly effective, safe, and simplified medical abortion regimen for general practice or self-administration is urgently needed.…”

Section: Introductionmentioning

confidence: 99%

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Efficacy, Safety, and Acceptability of Low-Dose Mifepristone and Self-Administered Misoprostol for Ultra-Early Medical Abortion: A Randomized Controlled Trial

Song

Tang

et al. 2017

Reprod. Sci.

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The aim of this study was to investigate the efficacy, safety, and acceptability of low-dose mifepristone combined with self-administered misoprostol for ultra-early medical abortion. A total of 744 women with ultra-early pregnancy (amenorrhea ≤35 days) who fulfilled the inclusion criteria were enrolled in the study. Equal numbers of participants were allocated randomly to the hospital administration and self-administration groups. All participants took 75 mg mifepristone at the initial visit and 400 µg oral misoprostol 24 hours later in the hospital or by self-administration. The primary end point was complete abortion. Secondary end points were rates of unscheduled reattendance, time required for and cost of hospital observation and follow-up, vaginal bleeding, adverse effects, menstrual disturbance in the posttreatment period, and satisfaction rating. No differences in the rates of complete abortion, unscheduled reattendance, vaginal bleeding, adverse effects, or return of posttreatment menstruation were observed. The time required for (and costs of) hospital observation and follow-up per participant was 557.82 minutes (and US$40.12) in the hospital administration group and 18.46 minutes (and US$1.96) in the self-administration group (both P < .001). Satisfaction rates were similar in both groups, but the rates of "very satisfied" responses (87.60% vs 25.41%) and follow-up compliance (loss to follow-up, 0.45% vs 7.70%) were higher in the self-administration group (both P < .001). Low-dose mifepristone combined with self-administered misoprostol for ultra-early pregnancy termination was as effective and safe as hospital administration, with greater acceptability and lower cost to the women.

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Section: Safety and Feasibility Of Self-administration Of A Low-dose Medical Abortion Regimenmentioning

confidence: 61%

Section: Introductionmentioning

confidence: 99%

Efficacy, Safety, and Acceptability of Low-Dose Mifepristone and Self-Administered Misoprostol for Ultra-Early Medical Abortion: A Randomized Controlled Trial

Song

Tang

et al. 2017

Reprod. Sci.

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“…Some authors showed that dose of mifepristone could reduce on 200mg and it could reach the same effects as with a dose of 600mg (15,16,17,18,19,20,21). After that it was turned out that the vaginal application of misoprostole was more effective than peroral drug aplication, specially in pregnancy age between 50-63 days gestation (22,23,24).…”

Section: Mifepristone and Misoprostolementioning

confidence: 98%

Drug Methods for Arteficial Termination of Unwanted Pregnancy

Dimitrijević

2018

Serbian Journal of Experimental and Clinical Research

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“…The success rate of abortion for mifepristone-misoprostol regimen is 95-98%. [41], while 78-90% for misoprostol only [42]. Despite highly restrictive abortion laws in LAC, access to safer abortion increased.…”

Section: Medical Terminationmentioning

confidence: 99%

Interventions for Failed Family Planning

Chien¹,

Au²

2018

Family Planning

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Despite the introduction of family planning services in most areas of the world, failures of contraceptive use often lead to unplanned pregnancies. These women often resort to unsafe methods to end their pregnancies, which contributes to the fourth leading cause of maternal mortality worldwide. Demographic variables that may affect the intention to discontinue the pregnancies would be demonstrated. Pros and cons of different types of induced abortions would be presented and discussed. Programs integrating counseling for women after failed family planning for future comprehensive reproductive health care will be shown. The gap between women's reproductive desire to avoid pregnancy and altitude of contraceptive use may contribute to the prevalence of unintended pregnancy. Age, race/ethnicity, marital status, and socioeconomic characteristics should be considered in counseling women after failed family planning. Expanding the program that offers integrated abortion training would prepare more physicians to provide comprehensive care for family planning.

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Feasibility and effectiveness of unintended pregnancy prevention with low-dose mifepristone combined with misoprostol before expected menstruation

Abstract: Menstrual regulation with low-dose mifepristone and misoprostol at expected menstruation can be efficacious and highly acceptable to maintain or restore non-pregnant status, which may have potential for routine contraception.

Cited by 5 publications

References 30 publications

Efficacy, Safety, and Acceptability of Low-Dose Mifepristone and Self-Administered Misoprostol for Ultra-Early Medical Abortion: A Randomized Controlled Trial

Efficacy, Safety, and Acceptability of Low-Dose Mifepristone and Self-Administered Misoprostol for Ultra-Early Medical Abortion: A Randomized Controlled Trial

Drug Methods for Arteficial Termination of Unwanted Pregnancy

Interventions for Failed Family Planning

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