Feasibility and Safety of Contrast-Enhanced Ultrasound of the Neonatal Brain: A Prospective Study Using MRI as the Reference Standard

Squires, Judy; Beluk, Nancy; Lee, Vince K.; Yanowitz, Toby; Gümüş, Serter; Subramanian, Subramanian; Panigrahy, Ashok

doi:10.2214/ajr.21.26274

Cited by 13 publications

(8 citation statements)

References 23 publications

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“…The risk of hypoxic-ischemic injury, intraventricular hemorrhage, PVL, and hemorrhagic hydrocephalus is significantly higher in preterm infants, which is an important tool for diagnosis and monitoring of brain injury in preterm infants. Therefore, studies have used MRI as the reference standard to evaluate the feasibility, safety, and diagnostic value of transfontanel cerebral CEUS in newborns ( 31 , 32 ). As shown in Figure 6D , the top 20 keywords that appear most frequently have new research directions in different stages with the deepening of the research, and their influence and research activity deserve attention.…”

Section: Discussionmentioning

confidence: 99%

Global trends in neonatal MRI brain neuroimaging research over the last decade: a bibliometric analysis

Xu,

Zhang,

Yue

et al. 2024

Quant Imaging Med Surg

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Background Neuroimaging plays a central role in the evaluation, treatment, and prognosis of neonates. In recent years, the exploration of the developing brain has been a major focus of research for researchers and clinicians. In this study, we conducted bibliometric and visualization analyses of the related studies in the field of neonatal magnetic resonance imaging (MRI) brain neuroimaging from the past 10 years, and summarized its research status, hotspots, and frontier development trends. Methods The Web of Science core collection database was used as the literature source from which to retrieve the relevant papers and reviews in the field of neonatal MRI brain neuroimaging published in the Science Citation Index-Expanded from 2013 to 2022. VOSviewer and CiteSpace were used to conduct bibliometric and visualization analyses of the annual publication volume, countries, institutions, journals, authors, co-cited literature, and the overall distribution of keywords. Results We retrieved 3,568 papers and reviews published from 2013 to 2022. The number of publications increased during this period. The United States (US) and the United Kingdom were the largest contributors, with the US receiving the highest H-index and number of citations. The institutions that published the most were the University of London and Harvard University. The research mainly focused on cerebral cortex, brain tissue, brain structure network, artificial intelligence algorithm, automatic image segmentation, and premature infants. Conclusions This study reveals the research status and hotspots of magnetic resonance imaging in the field of neonatal brain neuroimaging in the past decade, which helps researchers to better understand the research status, hotspots, and frontier development trends.

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Section: Discussionmentioning

confidence: 99%

Global trends in neonatal MRI brain neuroimaging research over the last decade: a bibliometric analysis

Xu,

Zhang,

Yue

et al. 2024

Quant Imaging Med Surg

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“…Distinguish complex from simple ovarian cysts. Distinguish gallbladder inspissated bile (tumefactive sludge) from vascularized soft tissue that may indicate neoplasm or focal adenomyomatosis 10 Improve diagnostic performance of US in infant brain evaluation 19,20 Evaluate neonatal brain hypoxic ischemic injury 21 …”

Section: Indicationsmentioning

confidence: 99%

“…Imaging should be performed continuously from contrast injection until the imaging target is adequately characterized. Presence and degree of arterial phase enhancement should be documented. Neonatal brain 19–21,33 Contrast dose: CEUS examination of the neonatal brain is performed using the standard pediatric weight‐based dose of 0.03 mL/kg SHLM contrast. Imaging: CEUS examination of the neonatal brain is performed with a small footprint curved‐array mid‐frequency transducer. CEUS is performed by saving cinematic clips. Once SHLM has been injected, care must be taken to only image in low mechanical index (MI), low TI, and low power output mode to avoid microbubble destruction and potential sonoporation. High MI pulses to clear the field should not be used. First, a wash‐in cinematic clip is obtained in the coronal plane at the level of the third ventricle for 30 seconds after contrast injection 20 …”

Section: Specification Of the Examinationmentioning

confidence: 99%

“…Presence and degree of arterial phase enhancement should be documented. Neonatal brain 19–21,33 Contrast dose: CEUS examination of the neonatal brain is performed using the standard pediatric weight‐based dose of 0.03 mL/kg SHLM contrast. Imaging: CEUS examination of the neonatal brain is performed with a small footprint curved‐array mid‐frequency transducer. CEUS is performed by saving cinematic clips. Once SHLM has been injected, care must be taken to only image in low mechanical index (MI), low TI, and low power output mode to avoid microbubble destruction and potential sonoporation. High MI pulses to clear the field should not be used. First, a wash‐in cinematic clip is obtained in the coronal plane at the level of the third ventricle for 30 seconds after contrast injection 20 Second, coronal anterior to posterior cinematic sweeps followed by right‐to‐left sagittal cinematic sweeps are saved to include both supratentorial and infratentorial structures. Finally, a cinematic sweep of the posterior fossa through the mastoid fontanelle is saved. Imaging may require more than one injection to visualize all relevant anatomy and pathology, depending on clinical indication. Pediatric voiding urosonography 34,35 Contrast dose: To date, published studies have used either SHLM contrast or PPM contrast.…”

Section: Specification Of the Examinationmentioning

confidence: 99%

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AIUM Practice Parameter for the Performance of Contrast‐Enhanced Ultrasound

2023

J of Ultrasound Medicine

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IntroductionT he American Institute of Ultrasound in Medicine (AIUM) is a multidisciplinary association dedicated to advancing the safe and effective use of ultrasound in medicine through professional and public education, research, development of clinical practice parameters, and accreditation of practices performing ultrasound examinations.The AIUM Practice Parameter for the Performance of Contrast-Enhanced Ultrasound (CEUS) was revised by the AIUM in collaboration with other organizations whose members use ultrasound for performing this examination(s) (see "Acknowledgments"). Recommendations for personnel requirements, the request for the examination, documentation, quality assurance, and safety may vary among the organizations and may be addressed by each separately.This Practice Parameter is intended to provide the medical ultrasound community with recommendations for the performance and recording of high-quality ultrasound examinations. The parameters reflect what the AIUM considers the appropriate criteria for this type of ultrasound examination but are not intended to establish a legal standard of care. Examinations performed in this specialty area are expected to follow the Parameter with recognition that deviations may occur depending on the clinical situation. IndicationsIndications for CEUS are based on the current literature recommendations and clinical practice standards.Ultrasound (US) contrast agents and contrast-specific scanning techniques have extended the diagnostic capabilities of US. CEUS should be considered as a useful problem-solving tool and as an indicated first-line imaging modality in select settings as indicated below.Ultrasound contrast has no renal toxicity or clearance; therefore, CEUS may be used at any level of renal function. CEUS is often safe for patients with contraindications to computed

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“…CEUSs have been used for the evaluation of acute ischemic stroke among an adult population to detect cerebral perfusion deficits and to monitor the responses to a thrombolytic treatment [ 49 , 50 ]. The number of studies on a pediatric population, so far, are minimal, but CEUSs have been shown to have good sensitivity to detect acute ischemic stroke in comparison to MRI [ 51 ]. For the imaging of stroke using CEUS, the quantitative brain perfusion analysis is typically performed.…”

Section: Clinical Applicationsmentioning

confidence: 99%

The Use of Contrast-Enhanced Ultrasound (CEUS) in the Evaluation of the Neonatal Brain

Plut,

Prutki,

Slak

2023

Children

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In recent years, advancements in technology have allowed the use of contrast-enhanced ultrasounds (CEUS) with high-frequency transducers, which in turn, led to new possibilities in diagnosing a variety of diseases and conditions in the field of radiology, including neonatal brain imaging. CEUSs overcome some of the limitations of conventional ultrasounds (US) and Doppler USs. It allows the visualization of dynamic perfusion even in the smallest vessels in the whole brain and allows the quantitative analysis of perfusion parameters. An increasing number of articles are published on the topic of the use of CEUSs on children each year. In the area of brain imaging, the CEUS has already proven to be useful in cases with clinical indications, such as hypoxic-ischemic injuries, stroke, intracranial hemorrhages, vascular anomalies, brain tumors, and infections. We present and discuss the basic principles of the CEUS and its safety considerations, the examination protocol for imaging the neonatal brain, and current and emerging clinical applications.

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Feasibility and Safety of Contrast-Enhanced Ultrasound of the Neonatal Brain: A Prospective Study Using MRI as the Reference Standard

Cited by 13 publications

References 23 publications

Global trends in neonatal MRI brain neuroimaging research over the last decade: a bibliometric analysis

Global trends in neonatal MRI brain neuroimaging research over the last decade: a bibliometric analysis

AIUM Practice Parameter for the Performance of Contrast‐Enhanced Ultrasound

The Use of Contrast-Enhanced Ultrasound (CEUS) in the Evaluation of the Neonatal Brain

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