Feasibility and Safety of Lung Cancer Screening and Prevention Program During the COVID-19 Pandemic

Milanese, Gianluca; Sabia, Federica; Sestini, Stefano; Ledda, Roberta Eufrasia; Rolli, Luigi; Suatoni, Paola; Sverzellati, Nicola; Sozzi, Gabriella; Apolone, Giovanni; Marchianò, Alfonso; Pastorino, Ugo

doi:10.1016/j.chest.2021.02.072

Cited by 6 publications

(5 citation statements)

References 8 publications

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“…We performed a naso-pharyngeal swab the day before the procedure and administered a health questionnaire the day of the procedure before admitting the patient to the radiology department. Our safety protocol was similar to those already reported in literature for other purpose and produced the same results: the rate of collateral diagnosis of suspected COVID infection during the control scan of the procedure was very low (only one patient) and comparable to those reported (0.2%) [15,16]. It is interesting that the rate of procedures cancelled or postponed (14%) was significantly lower than that reported for lung cancer screening (32.7%) probably due to the different nature of the examinations (voluntary nature of the screening compared to the potentially disruptive results of the diagnostic biopsy procedure).…”

Section: Resultssupporting

confidence: 83%

CT Scan-Guided Fine Needle Aspiration Cytology for Lung Cancer Diagnosis through the COVID-19 Pandemic: What We Have Learned

et al. 2023

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Background and rationale. Novel coronavirus-related disease (COVID-19) has profoundly influenced hospital organization and structures worldwide. In Italy, the Lombardy Region, with almost 17% of the Italian population, rapidly became the most severely affected area since the pandemic beginning. The first and the following COVID-19 surges significantly affected lung cancer diagnosis and subsequent management. Much data have been already published regarding the therapeutic repercussions whereas very few reports have focused on the consequences of the pandemic on diagnostic procedures. Methods. We, here, would like to analyze data of novel lung cancer diagnosis performed in our Institution in Norther Italy where we faced the earliest and largest outbreaks of COVID-19 in Italy. Results. We discuss, in detail, the strategies developed to perform biopsies and the safe pathways created in emergency settings to protect lung cancer patients in subsequent therapeutic phases. Quite unexpectedly, no significant differences emerged between cases enrolled during the pandemic and those before, and the two populations were homogeneous considering the composition and diagnostic and complication rates. Conclusions. By pointing out the role of multidisciplinarity in emergency contexts, these data will be of help in the future for designing tailored strategies to manage lung cancer in a real-life setting.

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Section: Resultssupporting

confidence: 83%

CT Scan-Guided Fine Needle Aspiration Cytology for Lung Cancer Diagnosis through the COVID-19 Pandemic: What We Have Learned

et al. 2023

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“…The findings align with published accounts of responses by individual breast, cervical, colorectal and lung cancer screening programmes 6 17 19 20 22 32–41. The literature ranged from reports from individual screening clinics or jurisdictions, to national cancer screening approaches.…”

Section: Discussionsupporting

confidence: 77%

Nimble Approach: fast, adapting, calculating and ethically mindful approach to managing colorectal cancer screening programmes during a pandemic

Baxter

Facey

Ruco

et al. 2022

BMJ Open Gastroenterol

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ObjectiveTo describe a conceptual framework that provides understanding of the challenges encountered and the adaptive approaches taken by organised colorectal cancer (CRC) screening programmes during the initial phase of the COVID-19 pandemic.DesignThis was a qualitative case study of international CRC screening programmes. Semi-structured interviews were conducted with programme managers/leaders and programme experts, researchers and clinical leaders of large, population-based screening programmes. Data analysis, using elements of grounded theory, as well as cross-cases analysis was conducted by two experienced qualitative researchers.Results19 participants were interviewed from seven programmes in North America, Europe and Australasia. A conceptual framework (‘Nimble Approach’) was the key outcome of the analysis. Four concepts constitute this approach to managing CRC screening programmes during COVID-19: Fast (meeting the need to make decisions and communicate quickly), Adapting (flexibly and creatively managing testing/colonoscopy capacity, access and backlogs), Calculating (modelling and actively monitoring programmes to inform decision-making and support programme quality) and Ethically Mindful (considering ethical conundrums emerging from programme responses). Highly integrated programmes, those with highly integrated communication networks, and that managed greater portions of the screening process seemed best positioned to respond to the crisis.ConclusionsThe Nimble Approach has potentially broad applications; it can be deployed to effectively respond to programme-specific challenges or manage CRC programmes during future pandemics, other health crises or emergencies.

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“…However, this structure needed to be converted to cope with the increased workload following the pandemic. Furthermore, tailored approaches are needed to guarantee safe management of patients, screenees and healthcare personnel [ 10 ].…”

Section: Methodsmentioning

confidence: 99%

Study rationale and design of the PEOPLHE trial

Milanese,

Silva,

Ledda

et al. 2024

Radiol med

Self Cite

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Purpose Lung cancer screening (LCS) by low-dose computed tomography (LDCT) demonstrated a 20–40% reduction in lung cancer mortality. National stakeholders and international scientific societies are increasingly endorsing LCS programs, but translating their benefits into practice is rather challenging. The “Model for Optimized Implementation of Early Lung Cancer Detection: Prospective Evaluation Of Preventive Lung HEalth” (PEOPLHE) is an Italian multicentric LCS program aiming at testing LCS feasibility and implementation within the national healthcare system. PEOPLHE is intended to assess (i) strategies to optimize LCS workflow, (ii) radiological quality assurance, and (iii) the need for dedicated resources, including smoking cessation facilities. Methods PEOPLHE aims to recruit 1.500 high-risk individuals across three tertiary general hospitals in three different Italian regions that provide comprehensive services to large populations to explore geographic, demographic, and socioeconomic diversities. Screening by LDCT will target current or former (quitting < 10 years) smokers (> 15 cigarettes/day for > 25 years, or > 10 cigarettes/day for > 30 years) aged 50–75 years. Lung nodules will be volumetric measured and classified by a modified PEOPLHE Lung-RADS 1.1 system. Current smokers will be offered smoking cessation support. Conclusion The PEOPLHE program will provide information on strategies for screening enrollment and smoking cessation interventions; administrative, organizational, and radiological needs for performing a state-of-the-art LCS; collateral and incidental findings (both pulmonary and extrapulmonary), contributing to the LCS implementation within national healthcare systems.

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Feasibility and Safety of Lung Cancer Screening and Prevention Program During the COVID-19 Pandemic

Abstract: Since the outbreak of COVID-19 pandemic, health care systems have focused on its containment, 1,2 facing critical issues in treating patients with medical disorders other than COVID-19, such as cancer and cardiovascular diseases. 2

Cited by 6 publications

References 8 publications

CT Scan-Guided Fine Needle Aspiration Cytology for Lung Cancer Diagnosis through the COVID-19 Pandemic: What We Have Learned

CT Scan-Guided Fine Needle Aspiration Cytology for Lung Cancer Diagnosis through the COVID-19 Pandemic: What We Have Learned

Nimble Approach: fast, adapting, calculating and ethically mindful approach to managing colorectal cancer screening programmes during a pandemic

Study rationale and design of the PEOPLHE trial

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