FEASIBILITY AND SAFETY OF PERIPHERAL BLOOD STEM CELL COLLECTION IN CHILDREN WITH POOR-PROGNOSIS SOLID TUMORS: A Single Center Experience

Долгополов, И. С.; Yankelevich, Maxim; Andreeva, Ludmila; Mscheidze, D.; Ijoguine, D.; Siegel, Stuart E.; Менткевич, Г. Л.

doi:10.1080/088800199277119

Cited by 4 publications

(6 citation statements)

References 11 publications

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“…Neither the mobilization technique nor the collection procedure are totally optimized. With the aim being to optimize the PBSC collection in low body weight patients with malignant disease, large volume leukapheresis was performed to collect a target number of 5 × 10 6 /kg CD34+ cells using a reduced number of procedures (12–14).…”

Section: Discussionmentioning

confidence: 99%

Mobilization and Harvesting of Peripheral Blood Stem Cells in Pediatric Patients With Solid Tumors

et al. 2011

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Survival of patients with high-risk pediatric solid tumors has improved with the introduction of a high-dose chemotherapy regimen and autologous stem cell rescue. Here, we present our data regarding the evaluation of the efficacy and safety of hematopoietic stem cell mobilization and harvesting in children with solid tumors. From November 2002 to March 2010, 85 children underwent autologous peripheral blood stem cell collection; 35 (41.1%) of them weighed less than 20 kg and were diagnosed with neuroblastoma, Wilms' tumor, medulloblastoma, yolk sac sarcoma, or non-Hodgkin's lymphoma. The mobilization regimens included disease-specific chemotherapy plus granulocyte colony-stimulating factor in most of the patients. The median age and weight at the time of apheresis was 36 months and 13.5 kg, respectively. Large-volume leukapheresis was performed with the aim of reducing the psychological and financial impact of leukapheresis by reducing the number of procedures while collecting a large number of cells. The median number of mobilization and leukapheresis procedures per case was one. The pre-apheresis CD34+ cell count ranged from 2 to 845 µL, with a median of 24 µL. A median of four patient blood volumes was processed per procedure, lasting 279 min (range, 113-420 min). A radial catheter was used for harvesting in 35 procedures (71.4%). The median yield of CD34+ cells was 6.6×10(6) /kg per patient. The targeted dose of 5×10(6) /kg CD34+ cells was realized in 80% of patients. The tolerance of peripheral blood stem cell collection in our patients was good. In conclusion, the collection of peripheral blood stem cells is an effective and safe procedure, even when conducted on the youngest children.

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Section: Discussionmentioning

confidence: 99%

Mobilization and Harvesting of Peripheral Blood Stem Cells in Pediatric Patients With Solid Tumors

et al. 2011

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“…PBSC collections were performed on Cobe Spectra and Baxter CS3000plus blood separators via a central double-lumen venous catheter at the bone marrow transplantation unit. The details of leukapheresis were reported previously [6]. Briefly, a median of two blood volumes were intended to be processed by leukapheresis for each patient in a 3-hr session with a maximal flow rate allowed by venous access.…”

Section: Pbsc Collectionmentioning

confidence: 99%

Delayed introduction of G‐CSF after chemotherapy does not affect peripheral blood stem cell yield and engraftment kinetics in children with high‐risk malignancies: Retrospective study of 45 cases

Долгополов¹,

Andreeva

Yankelevich³

et al. 2003

American J Hematol

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We retrospectively compared the effects of two time points of G-CSF (Filgrastim) introduction for PBSC mobilization in 45 children with different malignancies. Seventeen patients received the first G-CSF dose on day 2 or 3 following chemotherapy (group 1). Twenty-eight patients received a "flexible" G-CSF injection schedule when the G-GSF was started at the time of the first platelet count rise during post-chemotherapy recovery phase (group 2). Leukapheresis was performed when WBC recovery reached >2.0 × 10 9 /l or if the peripheral blood CD34 + cell level was >0.01 × 10 9 /l. A median of 2 (1-4) leukapheresis procedures was performed in both groups to yield a median of 4.2 and 6.1 × 10 6 CD34 + cells/kg in groups 1 and 2, respectively, which was generally sufficient for auto-transplantation. The proportion of patients with a failure of PBSC collection was similar and G-CSF consumption estimated through the total cycle dose was 2.3 times less in group 2 without increasing infectious risks. The short-term hematological recovery and the early post-transplant course were similar in the two groups. Delayed introduction of G-CSF after chemotherapy allowed PBSC harvest equivalent to that obtained after early G-CSF introduction. This approach could be an interesting alternative in PBSC mobilization but should be assessed by a prospective controlled study. Am. J. Hematol. 73:225-229, 2003.

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“…The possibility of many intensive CT courses with PBSC support was also shown. After 3 and more PCT courses, reinfusion of subtransplantation doses of peripheral stem cells mobilized with CSF after the fi rst and second PCT courses can shorten the duration of neutropenic fever and, hence, the intervals between CT courses, which gives hope for improving the results of treatment of children with high-risk STS [1]. The possibility of using this method for the treatment of patients with stage IV rabdomyosarcoma is demonstrated for multicyclic intensive CT with PBSC support.…”

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confidence: 95%

The Use of Autologous Peripheral Blood Stem Cells as a Hemopoietic Support during Polychemotherapy of Children with Soft Tissue Sarcomas

Иванова

Shvarova

2010

Bull Exp Biol Med

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FEASIBILITY AND SAFETY OF PERIPHERAL BLOOD STEM CELL COLLECTION IN CHILDREN WITH POOR-PROGNOSIS SOLID TUMORS: A Single Center Experience

Cited by 4 publications

References 11 publications

Mobilization and Harvesting of Peripheral Blood Stem Cells in Pediatric Patients With Solid Tumors

Mobilization and Harvesting of Peripheral Blood Stem Cells in Pediatric Patients With Solid Tumors

Delayed introduction of G‐CSF after chemotherapy does not affect peripheral blood stem cell yield and engraftment kinetics in children with high‐risk malignancies: Retrospective study of 45 cases

The Use of Autologous Peripheral Blood Stem Cells as a Hemopoietic Support during Polychemotherapy of Children with Soft Tissue Sarcomas

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