Feasibility and Utility of a Lung Donor Score: Correlation With Early Post-Transplant Outcomes

Outcome of critically ill lung transplant candidates on invasive respiratory support

“…A donor score (0-16 points) consisting of donor age, oxygenation index, chest X-ray, bronchoscopy finding and smoking history was calculated for each transplanted patient as previously described [17]. This score was modified by truncating the donor's smoking history to a maximum of 1, if present.…”

Availability of Lungs for Transplantation: Exploring the Real Potential of the Donor Pool

“…2, 15 We previously noted that a very high proportion of organ donors (even those we historically "excluded" from LTx on the basis of "poor function") can actually achieve a PaO 2 /FiO 2 of Ͼ300. 16 This group of donors, in particular, have formed the basis for expansion of lung-retrieval activities in recent years. Throughout Australia, ICU staff and donor coordinators routinely proactively manage and optimize all potential lung donors with transplantation in mind.…”

“…16,17 Attempts were made to optimize donor hemodynamics with intravenous fluid titrated to a central venous pressure (CVP) of around 10 mm Hg and the subsequent addition and titration of norepinephrine to maintain a suitable mean arterial pressure until the time of aortic cross-clamp application. Prior to September 2004 an intravenous infusion of prostacyclin (Flolan; GlaxoSmithKline, Australia) at 40 to 80 ng/kg/min was administered before an antegrade flush with cold modified Euro-Collins solution (60 ml/kg).…”

Detection of bronchial function of NHBD lung following one-h warm ischemia by organ bath model

“…Various strategies to increase the donor pool was necessary. Extended (marginal) donors [7] may increase the number of transplantation; however, for avoiding post-transplant primary graft dysfunction and mortality, extended donors should be used for non-high-risk recipients [8,9] . The living donors, as a alternative, are used for some small recipients who are desperate for transplantation [10,11] .…”