Feasibility and validity were demonstrated of an online case–control study using the prototype of recent-onset systemic lupus erythematosus

McAlindon, Timothy E.; Wang, Jun; Formica, Margaret K.; Kay, Ashley B.; Tighiouart, Hocine; Chaisson, Christine E.; Fletcher, Jeremiah

doi:10.1016/j.jclinepi.2007.07.019

Cited by 7 publications

(11 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The participants of the genetic analysis also showed overall similarity to the whole population of the parent online case–control study. 22 …”

Section: Resultsmentioning

confidence: 99%

“…The details of design and validation of this study are published. 22 Briefly, we constructed a study website to solicit participants and conduct the study. People searching for one of a set of pre-specified medical key terms using the Google search engine were directed towards our study website, where information about the study was provided along with links to an eligibility screening module, the consent form, and study questionnaires.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Association of estrogen and aromatase gene polymorphisms with systemic lupus erythematosus

Wang

Nuite

McAlindon

2010

Lupus

View full text Add to dashboard Cite

Experimental and animal studies suggested that estrogens play an important role in the development of systemic lupus erythematosus (SLE) through a variety of mechanisms involved in the regulation of the immune system. The objective of this study was to investigate the association between genetic variations in estrogen metabolic pathway genes, including estrogen receptor α (ESR1), estrogen receptor β (ESR2), and aromatase (CYP19A1), and risk of SLE. We performed a genetic study of SLE among 46 medical record-confirmed female SLE cases and 102 female controls participating in an Internet-based case–control study of SLE. Polymorphisms analysed included: ESR1 PvuII, XbaI, and GT repeat; ESR2 RsaI, AluI, and CA repeat; and CYP19A1 RsaI, SfaN1, and TTTA repeat. We found significant association of the ESR1 PvuII (PP vs. pp, odds ratio (OR): 3.1, 95% confidence interval (CI): 1.1–9.3) and XbaI (XX vs. xx, adjusted OR: 3.4, 95% CI: 1.1–10.5) with SLE. Carrying the PPXX genotype conferred the highest risk (PPXX vs. ppxx, OR: 4.6, 95% CI: 1.3–15.9). We also found an association of SLE with the ESR2 CA repeat (SS vs. LL, OR: 2.8, 95% CI: 1.0–8.0). Our results support a role of estrogen in pathogenesis of SLE and suggested that genetic variants in the estrogen receptor genes might influence susceptibility.

show abstract

“…The participants of the genetic analysis also showed overall similarity to the whole population of the parent online case–control study. 22 …”

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Association of estrogen and aromatase gene polymorphisms with systemic lupus erythematosus

Wang

Nuite

McAlindon

2010

Lupus

View full text Add to dashboard Cite

show abstract

“…We have previously described the feasibility and construct validity of this design [10]. Because this was one of the first case-control studies to use this approach, it would be prudent to view our results as hypothesis-generating.…”

Section: Discussionmentioning

confidence: 99%

“…The details of the design and validation of this approach has been previously described [10]. Briefly, we constructed a study website to solicit participants and conduct the study.…”

Section: Methodsmentioning

confidence: 99%

Is lipstick associated with the development of systemic lupus erythematosus (SLE)?

et al. 2008

Self Cite

View full text Add to dashboard Cite

Lipstick use has been hypothesized to be a risk factor of developing systemic lupus erythematosus (SLE). The objective of this study was to investigate the association between lipstick use and risk of SLE. We performed an Internet-based case-control study of SLE with Google™ users searching on medical key terms as the source population. Cases were diagnosed within 5 years and met ≥4 ACR criteria for SLE by medical record review. Controls were matched to cases on age, gender, race, ethnicity, region of residence, reference year, education, and income using propensity score. Demographic characteristics and lifestyle factors were collected using an online questionnaire. Conditional logistic regression models were used for the analyses with smoking, alcohol consumption, permanent hair dye use, and chemical hair straightener use adjusted. The analysis included 124 cases and 248 matched controls of whom 96% were females and 81% were whites. The median of disease duration was 2 years (range 0-4 years). Using lipstick at least 3 days/week was significantly associated with increased risk of SLE (adjusted OR = 1.71, 95%CI = 1.04-2.82). There was a trend of greater risk with earlier age of initiation of lipstick use (<16 years vs. never use; OR = 1.95, 95%CI = 1.01-3.76, p trend = 0.02) and with increased frequency of use (7 days/week vs. never use; OR = 1.75, 95%CI = 0.89-3.44, p trend = 0.07). Biologic effects of chemicals present in lipsticks absorbed across the buccal mucosa and confounding from unmeasured lifestyle factors could be the explanation of this association. Epidemiologic studies of SLE should include this exposure in exploring its environmental triggers.

show abstract

“…The details of design and validation of this approach has been previously described 7. Briefly, we constructed a study website to solicit participants and conduct the study.…”

Section: Methodsmentioning

confidence: 99%

Alcohol consumption is not protective for systemic lupus erythematosus

et al. 2008

View full text Add to dashboard Cite

Objective-Several studies have suggested that alcohol drinking is protective for the development and progression of systemic lupus erythematosus (SLE). However, a protopathic bias might also explain this apparent association. Our objective was to investigate the association between alcohol consumption and incidence of SLE in a data set that has information on both current and pre-diagnostic alcohol consumption.Methods-We performed an Internet-based case-control study of SLE. Cases were diagnosed within 5 years of the study and met ≥4 American College of Rheumatology criteria for SLE. The control participants were tightly matched to cases on demographic and socio-economic characteristics using a propensity score. Participants completed an online exposure assessment. We used conditional logistic regression analyses to test the association of current and prediagnostic alcohol consumption with SLE.Results-The sample comprised 114 cases with SLE and 228 matched controls. Current drinking (>2 days per week) was inversely associated with SLE (OR 0.35, 95% CI 0.13 to 0.98). Having more than two drinks per day was also inversely associated with SLE (OR 0.41, 95% CI 0.18 to 0.93). However, alcohol consumption before SLE diagnosis was not associated with the risk of SLE (p≥0.4). Analysis of the change in drinking habits showed that people with lupus were more likely to quit drinking before (OR 2.25, 95% CI 0.96 to 5.28) or after (OR 2.38, 95% CI 0.88 to 6.49) being given the SLE diagnosis.Conclusions-Our results show that alcohol consumption before SLE diagnosis is not associated with the risk for SLE, and that individuals who develop SLE are more likely to quit.The aetiology of systemic lupus erythematosus (SLE) involves both genetic predisposition and environmental risk factors yet to be identified. 1 Several epidemiological studies have reported an inverse association between alcohol consumption and SLE, suggesting that alcohol may be protective against the development of SLE. 2-4 However, these findings were constrained by the use of cross-sectional data, 2 prevalent cases 3 and/or the scarcity of exposure. 4 Because there is little biological rationale to support a protective effect of alcohol in the development of SLE, we hypothesised that the associations seen in previous studies may have resulted from some form of protopathic bias, which is an effect of disease on the exposure leading to a false perception of association. The development of intolerance for alcohol in individuals with early SLE is an example of how this might occur. The fact that there are other studies that did not find any significant associations between alcohol consumption and SLE 56 supports this hypothesis. In order to further explore our hypothesis, we analysed the relationship between SLE and alcohol exposure using detailed alcohol exposure data from an Internet-based case-control study of recent-onset SLE. To explore whether the post-diagnosis behaviour change may influence the association between alcohol consumption and SLE, we ana...

show abstract

Feasibility and validity were demonstrated of an online case–control study using the prototype of recent-onset systemic lupus erythematosus

Cited by 7 publications

References 21 publications

Association of estrogen and aromatase gene polymorphisms with systemic lupus erythematosus

Association of estrogen and aromatase gene polymorphisms with systemic lupus erythematosus

Is lipstick associated with the development of systemic lupus erythematosus (SLE)?

Alcohol consumption is not protective for systemic lupus erythematosus

Contact Info

Product

Resources

About