Feasibility of 1.6-mm isotropic voxel diffusion tensor tractography in depicting limbic fibers

Fujiwara, Shunrou; Sasaki, Makoto; Kanbara, Yoshiyuki; Inoue, Takashi; Hirooka, Ryonoshin

doi:10.1007/s00234-007-0317-y

Cited by 26 publications

(35 citation statements)

References 18 publications

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“…The precommissural and postcommissural fibers have also been difficult to image due to their proximity to the many crossing pathways near the mammillary bodies and hypothalamus. Previous papers focusing on tractography of the fornix have been limited by their inability to resolve these structures [48,49,50,51]. Jang et al [27] examined the FA values in the forniceal column, body and crura with a 1.5-tesla MRI magnet, which is a lower field strength than used in our work (3-tesla MRI) and results in lower resolution images.…”

Section: Discussionmentioning

confidence: 99%

Age-Related Changes in Diffusion Tensor Imaging Metrics of Fornix Subregions in Healthy Humans

Chen

Strauss²,

Hayes³

et al. 2015

Stereotact Funct Neurosurg

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Objective: White matter diffusivity measures of the fornix change with aging, which likely relates to changes in memory and cognition in older adults. Subregional variations in forniceal diffusivity may exist, given its heterogeneous anatomy and connectivity; however, these have not been closely examined in vivo. We examined diffusivity parameters (fractional anisotropy, FA; radial diffusivity, RD; axial diffusivity, AD) in forniceal subregions of healthy subjects and correlated them with age and hippocampal volume. Methods: Diffusion-weighted imaging and streamline tractography of the fornix were performed on 20 healthy, right-handed females (23-66 years). Six anatomical subregions were defined: midline (body, column, precommissural fornix) or lateral (fimbria, crura, postcommissural fornix). Regression analysis was performed comparing diffusivities against age. Hippocampal and ventricular volumes were also compared. Results: Diffusivity values revealed statistical changes with age in both midline and lateralized subregions. The fornix body and left crus showed age-related alterations in all metrics (FA, RD, AD), whereas only right crus FA was altered. There was no significant change in hippocampal volumes, suggesting that forniceal changes may precede hippocampal age-related changes. Conclusions: Age-related changes in fornix diffusivity measures appear subregion dependent and asymmetrical. Specific subregion diffusivity measures may be a more sensitive aging marker than hippocampal volume change.

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Section: Discussionmentioning

confidence: 99%

Age-Related Changes in Diffusion Tensor Imaging Metrics of Fornix Subregions in Healthy Humans

Chen

Strauss²,

Hayes³

et al. 2015

Stereotact Funct Neurosurg

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“…(1) To the best of our knowledge, DTT of the cingulate fi ber tracts in adult healthy volunteers was generated with the threshold values of line-tracking termination as FA > 0.15, 0.18, 0.20, or 0.30 in previous studies. [29][30][31][32][33][34][35] (2) Kunimatsu et al found that an FA value of around 0.20 was the optimal trackability threshold of FA for accurate and effi cient DTT of the corticospinal tract. They also expected that this FA threshold would be widely applicable to DTT of other tracts.…”

Section: Mri Acquisitionmentioning

confidence: 99%

Diffusion abnormality in posterior cingulate fiber tracts in Alzheimer’s disease: tract-specific analysis

et al. 2008

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The abnormal MD increase and FA decrease, which is considered to indicate a net loss of barriers that restrict water molecular motion and tissue anisotropy of white matter, is consistent with neuropathological data that demonstrate partial loss of myelin, axons, and oligodendrial cells in white matter of AD brains. Our results suggest that MD and FA reflect progression of AD-related histopathological changes in the PCFTs and may represent a useful biological index for monitoring AD.

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“…Especially important is the resolution in the z-axis, i.e., slice thickness, to obtain voxels that are near isotropic in shape. 16,17 When a regular slice thickness of 5 to 8 mm is used, the eŠect of partial volume averaging degrades the dataset and leads to apparently inferior tracking results (Fig. 5).…”

Section: Evolution In Imaging Techniquesmentioning

confidence: 99%

MR Tractography: A Review of Its Clinical Applications

Yamada

Sakai

Akazawa

et al. 2009

MRMS

276

174

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Feasibility of 1.6-mm isotropic voxel diffusion tensor tractography in depicting limbic fibers

Cited by 26 publications

References 18 publications

Age-Related Changes in Diffusion Tensor Imaging Metrics of Fornix Subregions in Healthy Humans

Age-Related Changes in Diffusion Tensor Imaging Metrics of Fornix Subregions in Healthy Humans

Diffusion abnormality in posterior cingulate fiber tracts in Alzheimer’s disease: tract-specific analysis

MR Tractography: A Review of Its Clinical Applications

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