Feasibility of 2–deoxy–2–[18F]fluoro–D–glucose– A85380–PET for imaging of human cardiac nicotinic acetylcholine receptors in vivo

Bucerius, Jan; Joe, Alexius; Schmaljohann, Jörn; Gündisch, Daniela; Minnerop, Martina; Biersack, Hans‐Jürgen; Wüllner, Ullrich; Reinhardt, Michaël

doi:10.1007/s00392-006-0397-4

Cited by 3 publications

(2 citation statements)

References 29 publications

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“…Less invasive techniques for evaluating sympathetic reinnervation involve tracking catecholamine radioisotopes like 123 I-meta-iodo-benzylguanidine (MIBG) and 11 Chydroxyephedrine (11C-HED) using positron emission tomography (PET) 247,248 . Vagal parasympathetic reinnervation after heart transplant can be assessed directly using PET tracers 249 or indirectly by measuring heart rate variability and monitoring its high frequency power spectrum 44,250 .…”

Section: Challenges and Advancements Towards Fabricating Innervated Tissue-engineered Constructsmentioning

confidence: 99%

Dysregulation of BRD4 Function Underlies the Functional Abnormalities of MeCP2 Mutant Neurons

et al. 2020

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Innervation plays a pivotal role as a driver of tissue and organ development as well as a means for their functional control and modulation. Therefore, innervation should be carefully considered throughout the process of biofabrication of engineered tissues and organs. Unfortunately, innervation has generally been overlooked in most non-neural tissue engineering applications, in part due to the intrinsic complexity of building organs containing heterogeneous native cell types and structures. To achieve proper innervation of engineered tissues and organs, specific host axon populations typically need to be precisely driven to appropriate location(s) within the construct, often over long distances. As such, neural tissue engineering and/or axon guidance strategies should be a necessary adjunct to most organogenesis endeavors across multiple tissue and organ systems. To address this challenge, our team is actively building axon-based "living scaffolds" that may physically wire in during organ development in bioreactors and/or serve as a substrate to effectively drive targeted long-distance growth and integration of host axons after implantation. This article reviews the neuroanatomy and the role of innervation in the functional regulation of cardiac, skeletal, and smooth muscle tissue and highlights potential strategies to promote innervation of biofabricated engineered muscles, as well as the use of "living scaffolds" in this endeavor for both in vitro and in vivo applications. We assert that innervation should be included as a necessary component for tissue and organ biofabrication, and that strategies to orchestrate host axonal integration are advantageous to ensure proper function, tolerance, assimilation, and bio-regulation with the recipient post-implant.

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Section: Challenges and Advancements Towards Fabricating Innervated Tissue-engineered Constructsmentioning

confidence: 99%

Dysregulation of BRD4 Function Underlies the Functional Abnormalities of MeCP2 Mutant Neurons

et al. 2020

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“…These include tracer developments to increase the specificity for imaging sympathetic nerve function, to assess more than simply norepinephrine uptake,2,55 and possibly to image cardiac parasympathetic nerve function56,57 or nerve spouting. In addition, advanced modeling of dynamic image sets may be able to improve the physiologic relevance of tracer parameters 58-60…”

Section: Clinical Application Of Sympathetic Nerve Imagingmentioning

confidence: 99%