Feasibility of a bilateral 4000–6000 Hz notch as a phenotype for genetic association analysis

Phillips, Susan L.; Richter, Scott J.; Teglas, Sandra; Bhatt, Ishan Sunilkumar; Morehouse, Robin; Hauser, Elizabeth R.; Henrich, Vincent C.

doi:10.3109/14992027.2015.1030512

Cited by 16 publications

(40 citation statements)

References 39 publications

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“…Repeated exposures can cause a chronic increase in oxidative stress leading to the loss of outer hair cells, and a permanent threshold shift in the auditory region of 3000-6000 Hz. 22 Acoustical factor of 4000 Hz notch is due to the transfer function of the ear. As any object facing a sound, the ear acts as a passive filter.…”

Section: Discussionmentioning

confidence: 99%

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Protective earphones and human hearing system response to the received sound frequency signals

Ghahnavieh

Pourabdian

Forouharmajd

2018

Journal of Low Frequency Noise, Vibration and Active Control

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Sound is one of the most important problems in industrial environments, and it causes hearing loss at different frequencies in the workforce. Incorrect fitting of hearing protector has a negative effect on noise reduction. The present study was conducted with the aim of determination of the effective frequencies on hearing loss and variations of the sound level in different frequencies after placing the earplug. A model of ear canal with different materials was simulated. Sound pressure sensors and earplugs were placed in both sides of the ear canal. The rates of sound reduction in octave frequency signals were calculated for the simulated canal of different materials, in different distances between the microphone and the earplug with Labview software. The results of sound simulation in octave frequency signals showed that by increasing the frequency, the rates of sound reduction in different conditions also had an increasing trend. The obtained peak rates for all the situations coincided with each other at fixed frequencies. In most cases, a noise reduction in the frequency of 4000 Hz showed a high number. The maximum sound reduction was observed at 25.5 mm at frequencies below 250 Hz, which was similar to the average of human ear canal length; so the simulated model can be used to determine the performance of the protective earphones and test them at different frequencies and sound pressure levels.

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Section: Discussionmentioning

confidence: 99%

“…Repeated exposures can cause a chronic increase in oxidative stress leading to the loss of outer hair cells, and a permanent threshold shift in the auditory region of 3000–6000 Hz. 22…”

Section: Discussionmentioning

confidence: 99%

Protective earphones and human hearing system response to the received sound frequency signals

Ghahnavieh

Pourabdian

Forouharmajd

2018

Journal of Low Frequency Noise, Vibration and Active Control

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“…In the clinic, a notch is often regarded as a strong indication of NIHL. Philips et al 10 . postulated that the audiometric notch may be regarded as a phenotype for identifying the genetic contributions to hearing loss.…”

Section: Introductionmentioning

confidence: 99%

Audiometric notch for the prediction of early occupational hearing loss and its association with the interleukin-1beta genotype

Amer

Taha

Ibrahim

et al. 2019

Journal of Taibah University Medical Sciences

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Objectives Noise-induced hearing loss (NIHL) is a frequent and irreversible industrial-health problem, the early diagnosis of which can prevent hearing deterioration, especially of speech frequencies. This study aimed to assess hearing impairment in workers occupationally exposed to noise. Audiometric notches and IL-1β gene polymorphisms were evaluated. Methods The study included 98 workers employed in a textile factory. Pure-tone audiometric testing was conducted for all workers, using a manual pure-tone diagnostic audiometer, and the noise level was measured at four different work sites in a spinning section. IL-1β gene polymorphism was determined using PCR-RFLP methods. Results Workers were exposed to a mean noise level of 105.5 dB. As many as 27.6% of them complained of tinnitus and the majority suffered from some degree of hearing loss in either ear, but none of them exceeded 60 dB. Audiometric notches were detected in either one or both ears. Only 28.6% of workers showed the absence of notches. The TT genotype of IL-1β polymorphisms was dominant in 49% of the workers, whereas TC was predominant in 39.8% and CC in 11.2%. The CC genotype was associated with smoking (54.5%) and audiometric notches (100%). The IL-1β genotype distribution showed no significant difference with or without tinnitus. Conclusion This study showed an association between the CC genotype and smoking as well as audiometric notches in workers occupationally exposed to noise. Workers showing audiometric notches should be followed up regularly. Further studies are required to confirm the interrelationship amongst tinnitus, audiometric notches, and IL-1β genotypes.

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“…reported the 4–6 kHz bilateral notch as a feasible phenotype for identifying genetic susceptibility to hearing loss. [ 14 ] In addition to audiometric notch confirming the diagnosis of NIHL, observed history of excessive occupational or non-occupational noise exposure was reported as an important factor in the confirmation of NIHL. [ 15 ] This calls for strict monitoring of the workplace noise level, periodic audiometric checkup, shape of the audiogram, and detailed history of the workers in particular.…”

Section: Introductionmentioning

confidence: 99%

Hearing threshold status and risk estimate of hearing impairment among administrative workforce

Majumder

Patel

Kotadiya

et al. 2018

Indian J Occup Environ Med

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Background:Administrative workers working in quieter environment workplace are considered unaffected by noise-induced hearing loss (NIHL).Aim:To create a baseline data of the administrative workers so as to monitor them with prospective years of exposure with the hypothesis that workers working in the administrative jobs may not be affected by NIHL.Settings and Design:The study was conducted among men and women administrative workers working in an office in Ahmedabad city, India. The design of the study was prospective cross-sectional study.Materials and Methods:In all, 64 men and 33 women administrative workers were recruited. Pure tone air conduction (AC) and unmasked bone conduction (BC) audiometry of both ears was performed. Pure tone averages (PTAs) and air-bone gap (ABG) were calculated. Excess risk of hearing impairment was estimated using five model equations.Statistical Analysis:Descriptive statistics was used for analysis. For calculation of excess risk of hearing impairment, models in online calculator were used.Results:AC for men depicted 4 and 6 kHz notch, whereas 6 kHz for women, for both ears. Around three-fourth men and nine-tenth women recorded hearing threshold <25 dB (A) for PTA0.5-1-2-4. ABG was <15 dB at all frequencies except 6 kHz, for both groups. Highest values of average estimated excess risk were 4.89% and 1.21% for men and women, respectively. Estimated excess risk ranged up to 1% for 50%–77% men and 82%–91% women.Conclusion:Administrative workers are minimally risked of developing NIHL; however, with progressive age, hearing ability may deteriorate.

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Feasibility of a bilateral 4000–6000 Hz notch as a phenotype for genetic association analysis

Cited by 16 publications

References 39 publications

Protective earphones and human hearing system response to the received sound frequency signals

Protective earphones and human hearing system response to the received sound frequency signals

Audiometric notch for the prediction of early occupational hearing loss and its association with the interleukin-1beta genotype

Hearing threshold status and risk estimate of hearing impairment among administrative workforce

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