Feasibility of a multimodal intervention on malnutrition in patients with lung cancer during primary anti-neoplastic treatment

Tobberup, Randi; Carus, Andreas; Rasmussen, H.H.; Falkmer, Sture; Jørgensen, Martin Grønbech; Schmidt, Erik Berg; Jensen, Nikolaj Aarøe; Mark, Esben Bolvig; Delekta, Agnieszka Monika; Antoniussen, Christian S.; Bøgsted, Martin; Holst, Mette

doi:10.1016/j.clnu.2020.05.050

Cited by 24 publications

(25 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A multidisciplinary intervention model for cancer cachexia is presented in Figure 3. In addition to anti-inflammatory, metabolism-improving, and appetite-improving medications, high-quality nutritional therapy and appropriate exercise tailored to the patient's physical function can help improve physical function as well as increase skeletal muscle mass [112][113][114]. These strategies will become even more necessary in the future.…”

Section: Multidisciplinary Intervention Modelmentioning

confidence: 99%

Cancer Cachexia: Its Mechanism and Clinical Significance

Nishikawa

Goto

Fukunishi

et al. 2021

IJMS

142

View full text Add to dashboard Cite

The term “cachexia” is derived from the Greek words kakos (bad) and hexis (habit). Cachexia is a malnutrition associated with chronic diseases such as cancer, chronic heart failure, chronic renal failure, and autoimmune diseases, and is characterized by decreased skeletal muscle mass. Cancer cachexia is quite common in patients with advanced cancer. Weight loss is also a characteristic symptom of cancer cachexia, along with decreased skeletal muscle mass. As nutritional supplementation alone cannot improve cachexia, cytokines and tumor-derived substances have been attracting attention as its relevant factors. Cancer cachexia can be also associated with reduced chemotherapeutic effects, increased side effects and treatment interruptions, and even poorer survival. In 2011, a consensus definition of cachexia has been proposed, and the number of relevant research reports has increased significantly. However, the pathogenesis of cachexia is not fully understood, and there are currently few regulatory-approved standard treatments for cachexia. The main reason for this is that multiple etiologies are involved in the development of cachexia. In this review, we will outline the current status of cachexia, the mechanisms of which have been elucidated in recent years, especially from the perspective of advanced cancer.

show abstract

Section: Multidisciplinary Intervention Modelmentioning

confidence: 99%

Cancer Cachexia: Its Mechanism and Clinical Significance

Nishikawa

Goto

Fukunishi

et al. 2021

IJMS

142

View full text Add to dashboard Cite

show abstract

“…This review found 19 publications[ 16 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 ] reporting a multimodal intervention for cancer cachexia with a psychosocial component and published from January 2013 to March 2021. They included complex interventions used in practice ( n = 3),[ 27 28 38 ] tested in the context of a feasibility study ( n = 6)[ 16 24 29 32 36 40 ] or pilot/early phase trial ( n = 5),[ 23 24 31 33 39 ] and theorized approaches drawing on existing literature and expert opinion ( n = 6). [ 25 26 30 34 35 37 ] The interventions tested were found to be feasible and safe (when adverse events and safety issues were reported [ n = 8]).…”

Section: Resultsmentioning

confidence: 99%

“…Fourteen interventions included exercise. [ 26 28 29 30 31 32 33 34 35 36 37 38 39 40 ] A distinction was made between exercise and physical activity in five of these interventions, with support provided for both. [ 26 29 32 33 36 ] Exercise typically included resistance training (e.g., stand to sit exercises in the home) and aerobic exercise (e.g., walking) tailored to the individual's capability with goals set to support engagement and to inform personalization of the program.…”

Section: Exercise and Physical Activitymentioning

confidence: 99%

“…Nutritional counseling was a core component of 14 interventions. [ 24 27 28 29 30 31 32 33 34 35 36 38 39 40 ] Its aim was to increase energy, protein, and/or overall nutrient intake so as to maintain or increase body weight. Counseling supported protein, energy, and nutrient intake according to need ( n = 9),[ 16 26 29 30 31 33 36 38 40 ] with the nature of interventions indicating an underpinning assumption of need to increase oral intake.…”

Section: Nutritional Supportmentioning

confidence: 99%

See 1 more Smart Citation

The Psychosocial Components of Multimodal Interventions Offered to People with Cancer Cachexia: A Scoping Review

Hopkinson

2021

Asia-Pacific Journal of Oncology Nursing

View full text Add to dashboard Cite

The supportive care of people with cancer cachexia is a rapidly evolving field. In the past decade, multimodal treatments have been developed and new multidisciplinary cachexia clinics have been established across the world. This scoping review examines the extent to which psychosocial support has become part of the multimodal management of cancer cachexia. The review draws on a systematic search of Medline, Embase, CINAHL, PsycINFO, and the Cochrane Library for publications about people who have cancer cachexia and receive multimodal interventions. Search limits were the English language, date range January 2013 to March 2021, and adults 18 years and older. The search found 19 papers about multimodal interventions for either cancer cachexia or its defining feature involuntary weight loss that included a psychosocial component. This review found three different ways a psychosocial component of a multimodal intervention can help patients: (1) enable adherence to multimodal therapies; (2) aid emotional adaptation and coping; and (3) treat comorbid anxiety and depression. Recognizing these three different functions of psychosocial support is important because they have different mechanisms of action. Behavioral change techniques are important for enabling adherence, education in coping methods is important to alleviate stress, and cognitive reframing for the treatment of anxiety and depression. The analysis reveals that multimodal interventions for cancer cachexia with a psychosocial component can either focus on physical health or have a more holistic focus. Holistic care is considered the best practice in cancer nursing. Thus multimodal interventions that can address not only physical health problems, but psychosocial issues are consistent with high-quality nursing care.

show abstract

“…Pela significância estatística encontrada na banda de frequência de 7 a 10 Hz, algumas hipóteses podem ser levantadas, uma vez que mudanças nesta banda estariam relacionadas a um tremor, como pode ser visto em alguns estudos (Vaillancourt et al, 2001;Sturman et al, 2005). Na banda 03 a 1 Hz supõe que seja a respiração, a variável que atua na diferença os pacientes do grupo teste com as pessoas do grupo controle, pois os pacientes caquéticos tem uma intensa depleção da massa magra (Fernandes et al, 2020), afetando os músculos respiratórios, e que por serem afetados, dificultam a realização de atividades físicas, e com o treinamento de força tem uma mudança no padrão de absorção de nutrientes melhorando o funcionamento do metabolismo, que é afetado pelas necessidades energéticas do tumor (Tobberup et al 2020), com isso os processos anabólicos são aumentados, dependendo do tempo de treinamento restabelece a massa magra, diminuindo assim as diferenças entre os grupos.…”

Section: Discussionunclassified

Câncer e Caquexia: influência de um protocolo de exercícios terapêuticos no processo saúde e doença

Valentim

Souza

Quaresma

2020

RSD

View full text Add to dashboard Cite

O câncer é uma condição clínica decorrente da proliferação celular desordenada, e tem sua associação com a caquexia, em parte dos casos, essa condição acaba por agravar o quadro do paciente, devido à intensa depleção da massa magra e do tecido adiposo, o que ocasiona alterações imunológicas que comprometem a eficácia da terapia medicamentosa. Objetivo: Este estudo teve como objetivo avaliar os efeitos terapêuticos da aplicação de exercícios resistidos de intensidade moderada em pacientes caquéticos com câncer do trato gastrointestinal. Metodologia: Foram selecionados 20 indivíduos saudáveis e sedentários para o grupo controle, com faixa etária similar ao grupo teste que foi composta por 20 pacientes oncológicos com câncer gastrointestinal, associados à caquexia, e as avaliações foram realizadas com os seguintes instrumentos: célula de carga, análise nutricional do cardápio, valor energético total (VET), taxa metabólica basal (TMB). Foi avaliado o cardápio e controle motor antes e depois do protocolo de exercícios resistidos, comparado a um grupo de pessoas normais sem associação com a patologia e após o protocolo de exercício, o grupo de pacientes demonstrou um aumento e controle de força que se aproximou do grupo sadio, sendo estatisticamente significativo Resultados: Alguns pacientes não tinham o aporte calórico adequado tanto quando comparado a taxa metabólica basal como quando adicionado uma prática de exercícios, visualizado através do cálculo do valor energético total, acerca da avaliação de força, houve uma melhora significativa entre a primeira e segunda avaliação, apesar do tempo de protocolo não ter sido suficiente para produção de massa magra. Conclusão: Os resultados encontrados sugerem que esse tratamento deva ser aplicado por mais tempo do que o desenvolvido para avaliar se o aporte calórico estava adequado, e se o protocolo proposto seria eficaz para a produção de massa muscular nesses pacientes que apresentam processos catabólicos graves, avaliando a individualidade biológica dos cada paciente, atendendo assim às necessidades metabólicas.

show abstract

Feasibility of a multimodal intervention on malnutrition in patients with lung cancer during primary anti-neoplastic treatment

Cited by 24 publications

References 43 publications

Cancer Cachexia: Its Mechanism and Clinical Significance

Cancer Cachexia: Its Mechanism and Clinical Significance

The Psychosocial Components of Multimodal Interventions Offered to People with Cancer Cachexia: A Scoping Review

Câncer e Caquexia: influência de um protocolo de exercícios terapêuticos no processo saúde e doença

Contact Info

Product

Resources

About