Feasibility of Adequate Thrombolytic Therapy with Streptokinase in Peripheral Arterial Occlusions: I. Clinical and Arteriographic Results

Anticoagulant and Thrombolytic Drugs1 II

“…The feasibility of thrombolytic therapy in the dissolution of thrombus causing peripheral arterial occlusions has been demonstrated by arteriography (Verstraete et al, 1963;McNicol and Douglas, 1964). Surgery should be used, however, to restore the patency of major arteries where the danger of tissue necrosis exists because of the delay occasioned by the use of thrombolytic agents.…”

Arterial Occlusion Treated with Streptokinase

“…It may be that a haemolytic type of anaemia is usually present in this disease. However, no THE PLASMINOGEN activator streptokinase was first given intravenously to human volunteers by Tillett, Johnson and McCarty (1955) and subsequently has been used as a thrombolytic agent, case reports having recently been published in British journals (Cotton, Flute and Tsapogas, 1962;McNicol, Reid, Bain, and Douglas, 1963;Verstraete, Amery and Vermylen, 1963). Streptokinase may be administered by one of two methods; either intravenous infusion starting with a calculated loading dose, thus providing a high level of streptokinase throughout the circulation, or by local infusion into the affected artery proximal to the actual occlusion.…”

Outcome of Recent Thromboembolic Occlusions of Limb Arteries Treated with Streptokinase

“…During the administration of streptokinase in patients with a recent thromboembolic occlusion of a limb artery, patency of the main artery can be restored (Fletcher et al, 1959;Gross et al, 1960;Kahn et al, 1961;Cotton et al, 1962;Nilsson and Olow, 1962;McNicol et al, 1963;Salmon et al, 1963;Schmutzler, 1963Schmutzler, , 1968Verstraete et al, 1963;Winckelmann et al, 1963;Marchal et al, 1964;Haan and Tilsner, 1965;Hess, 1967). Nevertheless, neither the incidence of spontaneous disobstruction nor the optimal dose and duration of streptokinase therapy have yet been established.…”