Feasibility of an Adaptive Strategy in Preoperative Radiochemotherapy for Rectal Cancer With Image-Guided Tomotherapy: Boosting the Dose to the Shrinking Tumor

Passoni, P.; Fiorino, Claudio; Slim, N.; Ronzoni, Monica; Ricci, Vincenzo; Palo, S. Di; Nardi, Paola De; Orsenigo, Elena; Tamburini, A.; Cobelli, Francesco De; Losio, Claudio; Iacovelli, Nicola Alessandro; Broggi, S.; Staudacher, C.; Calandrino, R.; Muzio, N. Di

doi:10.1016/j.ijrobp.2013.05.004

Cited by 45 publications

(44 citation statements)

References 16 publications

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“…Ongoing clinical trials to develop more effective preoperative strategies for LARC patients address newer chemotherapeutics, targeted agents, induction chemotherapy, and novel radiotherapy methods (Malik et al, 2010;Rodel et al, 2010;Landry et al, 2013;Passoni et al, 2013). The endpoint in these trials is frequently a pathological CRT response.…”

Section: Discussionmentioning

confidence: 99%

Carbohydrate Antigen 19-9 Levels Associated with Pathological Responses to Preoperative Chemoradiotherapy in Rectal Cancer

Yeo

Kim

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 99%

Carbohydrate Antigen 19-9 Levels Associated with Pathological Responses to Preoperative Chemoradiotherapy in Rectal Cancer

Yeo

Kim

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Result of tumor response in regard to surgical findings was promising with 7 patients showing no residual viable cells and 12 patients having less than 10% residual viable cells after RT. Only acute complication scoring was available with three patients reported CTCAE Grade 3 toxicity [57].…”

Section: Online Plan Selection Based Multiple Plan Cbctsmentioning

confidence: 99%

Adaptive radiotherapy strategies for pelvic tumors – a systematic review of clinical implementations

et al. 2016

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“…The combination of SIB with adaptive treatment strategies is a particularly exciting venue for research: The definition of the boost volume could e.g. be guided by response to induction chemotherapy, as investigated by Seierstad and colleagues (14), or by response part-way through the radiotherapy treatment course (20). The group at the San Raffaele Scientific Institute in Milan has done particularly interesting work, including investigation of the use of optimized treatment margins for safe delivery of an adaptive SIB during the second half of the treatment course (20,38,39).…”

Section: Treatment Intensification Driven By Imrt / Vmatmentioning

confidence: 99%

Technological advances in radiotherapy of rectal cancer: opportunities and challenges

Appelt

Sebag‐Montefiore

2016

Current Opinion in Oncology

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Purpose of review:This review summarizes the available evidence for the use of modern radiotherapy techniques for chemoradiotherapy (CRT) for rectal cancer, with specific focus on intensity-modulated radiotherapy (IMRT) and volumetric arc therapy (VMAT) techniques. Recent findings:The dosimetric benefits of IMRT and VMAT are well-established, but prospective clinical studies are limited, with phase I-II studies only. Recent years have seen the publication of a few larger prospective patient series as well as some retrospective cohorts, several of which include much needed late toxicity data. Overall results are encouraging, as toxicity levels although varying across reports appear lower than for 3D conformal radiotherapy. Innovative treatment techniques and strategies which may be facilitated by the use of IMRT/VMAT include simultaneously integrated tumour boost, adaptive treatment, selective sparing of specific organs to enable chemotherapy escalation, and non-surgical management. Summary:Few prospective studies of IMRT and VMAT exist, which causes uncertainty not just in regards to the clinical benefit of these technologies but also in the optimal use. The priority for future research should be subgroups of patients who might receive relatively greater benefit from innovative treatment techniques, such as patients receiving CRT with definitive intent and patients treated with dose escalation.

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Feasibility of an Adaptive Strategy in Preoperative Radiochemotherapy for Rectal Cancer With Image-Guided Tomotherapy: Boosting the Dose to the Shrinking Tumor

Cited by 45 publications

References 16 publications

Carbohydrate Antigen 19-9 Levels Associated with Pathological Responses to Preoperative Chemoradiotherapy in Rectal Cancer

Carbohydrate Antigen 19-9 Levels Associated with Pathological Responses to Preoperative Chemoradiotherapy in Rectal Cancer

Adaptive radiotherapy strategies for pelvic tumors – a systematic review of clinical implementations

Technological advances in radiotherapy of rectal cancer: opportunities and challenges

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