“…Eighteen studies (36.7%) were categorized as pilot, feasibility, or proof-of-concept trials. 9 , 10 , 12 , 13 , 14 , 17 , 24 , 30 , 33 , 36 , 37 , 38 , 42 , 45 , 47 , 52 , 56 , 57 In general, the studies had relatively small sample sizes, where 23 studies (46.9%) had â€20 participants, 9 , 10 , 11 , 12 , 15 , 16 , 22 , 25 , 26 , 27 , 28 , 32 , 34 , 35 , 36 , 38 , 41 , 43 , 44 , 45 , 47 , 50 , 57 22 studies (44.9%) had between 21 and 100 participants, 13 , 14 , 17 , 18 , 19 , 20 , 21 , 23 , 24 , 29 , 30 , 31 , 33 , 40 , 42 , 46 , 49 , 51 , 52 , 53 , 54 and 4 studies (8.2%) had >100 participants (see table 1 ).…”